Showing Protein Aldehyde oxidase 1 (BMDBP00677)
| Identification | |||||||||||
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| BMDB Protein ID | BMDBP00677 | ||||||||||
| Secondary Accession Numbers |
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| Name | Aldehyde oxidase 1 | ||||||||||
| Synonyms | Not Available | ||||||||||
| Gene Name | AOX1 | ||||||||||
| Protein Type | Enzyme | ||||||||||
| Biological Properties | |||||||||||
| General Function | Nucleotide transport and metabolism | ||||||||||
| Specific Function | Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis. | ||||||||||
| Pathways | Not Available | ||||||||||
| Reactions |
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| GO Classification | Not Available | ||||||||||
| Cellular Location | Not Available | ||||||||||
| Gene Properties | |||||||||||
| Chromosome Location | 2 | ||||||||||
| Locus | Not Available | ||||||||||
| SNPs | AOX1 | ||||||||||
| Gene Sequence |
>4020 bp ATGGAAGGGGGCTCCGAGCTGCTCTTCTACGTGAACGGCCGCAAGGTGACAGAAAAAAAT GTTGATCCTGAAACAATGCTATTGCCATATCTGAGGAAAAAGCTCCGACTCACAGGAACT AAATATGGCTGTGGAGGGGGAGGCTGTGGTGCCTGCACAGTGATGATATCACGATATAAC CCCATTACCAAGAAGATAAGACATTATCCAGCCAACGCCTGTCTGACGCCCATCTGTTCT CTGTATGGGGCTGCCGTCACCACAGTAGAAGGCATAGGAAGCACCAAGACCAGGATTCAT CCTGTTCAGGAGAGGATTGCCAAGTGTCACGGCACGCAGTGTGGCTTCTGCACCCCCGGG ATGGTGATGTCCCTGTACACGCTGCTGAGGAACCATCCGGAGCCCACCCTGACTCAGCTA AATGATGCTCTTGGTGGTAACCTGTGTCGTTGCACTGGATACAGGCCCATAATCAATGCA TGCAAGACTTTCTGTAAAACTTCTGGCTGCTGTCAAAGTAAAGAAAATGGGGTTTGCTGT TTGGATCAAGGAATGAATGGATTACCAGAATTTGAGGAAGGAAATGAGACAAGTCTGAAA CTCTTCTCAGAAGAGGAGTTTCTGCCATTGGATCCAACTCAAGAGCTGATATTTCCTCCC GAGCTAATGACAATGGCTGAGAAAAAAACACAGAAGACCAGGATTTTTGGTAGTGATAGA ATGACCTGGATTTCCCCAGTGACCCTGAAGGAACTTCTAGAAGCCAAAGTCAAGTATCCC CAGGCCCCTGTTGTCATGGGGAACACCTCTGTGGGCCCTGACATGAAATTTAAAGGCATC TTTCACCCAGTTATAATTTCTCCTGATAGAATTGAAGAACTGAGTGTTGTAAACTATACA GATAACGGGCTGACCTTAGGTGCTGCTGTCAGCCTCGCTGAGGTGAAAGACATCCTGGCT AATGTGACCCGGAAACTCCCTGAGGAGAAGACACAGATGTACCATGCTCTCCTGAAACAT TTGGAAACTCTGGCTGGGCCGCAGATCAGGAATATGGCTTCTTTAGGGGGCCACATAGTG AGCAGGCATCCAGATTCAGATCTGAACCCTCTCCTGGCTGTGGGCAACTGTACCCTCAAC CTGCTGTCAAAAGAAGGAAGACGACAGATTCCTTTAAATGAGCAGTTTCTCAGAAAGTGC CCAAGTGCCGATCTTAAGCCTGAAGAAATCTTGATCTCAGTGAACATCCCCTATTCAAGG AAGTGGGAGTTTGTGTCAGCCTTCCGACAAGCCCAGCGGCAACAGAATGCGCTTGCAATA GTTAATTCGGGAATGAGAGTGTGTTTTGGAAAAGGAGATGGCATCATCAGAGAGTTATCC ATTGCATACGGAGGCGTTGGTCCAACCACCATCCTTGCAAATAATTCCTGCCAGAAACTC ATTGGAAGGCCCTGGAATGAAGAGATGCTGGATGCAGCTTGCAGGCTGATTCTGGATGAA GTCTCCCTCCCAGGCTCAGCCCCAGGTGGGAGGGTGGAGTTCAAGAGGACCCTCATTGTC AGCTTCCTGTTCAAGTTCTACCTGGAAGTGTCACAGATTTTGAAGGGGATGGACCTTGTT CACTATCCTAGCCTTGCAAGCAAATATGAGAGTGCTTTAGAAGATCTTCATTCCAGACAT TACTGGAGTACATTAAAGTACCAGAATGCAGACCTAAAGCAGCTTTCTCAAGACCCAATT GGCCATCCCATCATGCACCTGTCTGGTATTAAGCATGCCACGGGCGAAGCCATCTACTGT GACGACATGCCTGTGGTGGACCGGGAACTGTTCTTGACTTTTGTAACAAGTTCAAGAGCT CATGCTAAGATTGTGTCTATCGATGTCTCTGCAGCTCTCAGCCTGCCTGGGGTGGTAGAC ATCCTGACTGGGGAACATCTTCCAGGCATCAACACCACCTTTGGCTTTTTAACTGACGCT GATCAACTTCTGTCAACAGATGAGGTGTCTTGTGTGGGTCAGCTTGTCTGCGCCGTGATA GCCGATTCCGAGGTCCAGGCAAGGCGAGCTGCTCAGCAAGTGAAGATTGTCTACCAAGAT TTGGAGCCAGTGATCCTAACCATTGAGGAAGCTATACAAAACAAGTCCTTCTTTGAGCCA GAGAGGAAACTGGAGTATGGAAATGTGGATGAAGCATTTAAAATGGTGGATCAAATTCTT GAAGGTGAAATACACATGGGAGGTCAAGAACACTTTTATATGGAAACCCAGAGCATGCTG GTTGTTCCCAAAGGAGAAGATCGAGAAATCGATGTCTACGTGTCTGCTCAGTTTCCTAAA TACATACAGGACATAACTGCTTCAGTCTTGAAGGTCTCAGCTAACAAAGTCATGTGTCAC GTAAAGCGTGTTGGTGGAGCCTTTGGGGGAAAGGTGACAAAAACTGGCGTCCTGGCAGCC ATCACCGCATTTGCTGCAAACAAGCATGGTCGTCCAGTCCGCTGCATTCTGGAACGAGGA GAAGACATATTAATAACTGGAGGCCGCCACCCTTACCTTGGAAAGTATAAAGCTGGATTC ATGAATGATGGCAGAATCTTGGCCCTGGATATGGAGCATTATAACAATGCAGGTGCCTTC CTGGATGAGTCATTATTTGTAATAGAGATGGGACTTCTGAAACTGGAAAATGCCTACAAG TTTCCCAACCTGCGCTGCCGGGGGTGGGCGTGCAGAACCAACCTTCCATCCAACACAGCT TTGCGAGGGTTTGGCTTTCCCCAGGCAGGGCTGATCACCGAAGCCTGTATCACAGAAGTG GCAGCCAAATGTGGGTTGCCCCCTGAGAAGGTCCGAATGATAAACATGTATAAGGAAATT GATCAAACACCCTACAAACAGGAGATTAATACCAAGAACCTGACCCAGTGTTGGAAAGAA TGCATGGCCACGTCTTCCTACACCCTAAGGAAAGCAGCGGTGGAGAAATTCAACTCGGAG AATTACTGGAAGAAGAAGGGGCTGGCAATGGTCCCCCTGAAGTATCCTATTGGCCTTGGA TCAGTTGCTGCTGGTCAGGCTGCTGCCCTGGTTCACATTTATCTGGATGGGTCTGTGCTG GTGACTCACGGTGGAATTGAAATGGGGCAGGGGGTCCACACTAAAATGATTCAGGTGGTG AGTCGTGAGTTAAGGATGCCACTGTCCAGTATCCACCTCCGGGGAACAAGCACAGAAACC ATCCCTAATACAAATCCCTCTGGAGGTTCCGTAGTGGCTGATCTCAACGGGTTGGCAGTA AAGGATGCTTGTCAGACTCTTCTGAAACGCCTTAAACCCATCATCAGCAAGAATCCCAAA GGCACTTGGAAAGATTGGGCACAGGCTGCCTTTAATGAAAGCATTAGTCTCTCAGCTACT GGATACTTCAGGGGTTATGAGTCGAACATAAACTGGGAGACAGGCGAAGGCCACCCTTTC GAATACTTTGTTTATGGAGCAGCCTGTTCCGAGGTTGAGATAGACTGCCTGACAGGTGCT CATAAGAACATCAGAACAGACATTGTCATGGATGTTGGCTACAGTATAAATCCAGCCCTT GACGTAGGCCAGATTGAAGGTGCATTTATTCAAGGCATGGGACTTTATACAATAGAGGAA CTGAATTATTCTCCTCAAGGTGTCCTGTACACCCGGGGCCCGAACCAGTATAAAATCCCT GCCATCTGTGACATCCCCATGGAGCTGCACATTTCTTTTTTGCCTCCCTCTGAAAACTCG AATACCCTGTATTCGTCTAAGGGTCTGGGAGAGTCTGGGATATTCCTGGGGTGCTCAGTG TTTTTCGCCATCCACGATGCAATAAGGGCAGCACGACAGGAGAGAGGCCTGCCTGGACCA CTGAGGCTCAACAGCCCACTGACTCCAGAGAAGATTAGAATGGCCTGTGAAGACAAGTTC ACAAAAATGATTCCAAGAGATGAACCTGGATCGTATGTTCCTTGGAGTGTACCCATATGA |
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| Protein Properties | |||||||||||
| Number of Residues | 1339 | ||||||||||
| Molecular Weight | 147611.0 | ||||||||||
| Theoretical pI | 7.29 | ||||||||||
| Pfam Domain Function | Not Available | ||||||||||
| Signals |
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| Transmembrane Regions | Not Available | ||||||||||
| Protein Sequence |
>Aldehyde oxidase MEGGSELLFYVNGRKVTEKNVDPETMLLPYLRKKLRLTGTKYGCGGGGCGACTVMISRYN PITKKIRHYPANACLTPICSLYGAAVTTVEGIGSTKTRIHPVQERIAKCHGTQCGFCTPG MVMSLYTLLRNHPEPTLTQLNDALGGNLCRCTGYRPIINACKTFCKTSGCCQSKENGVCC LDQGMNGLPEFEEGNETSLKLFSEEEFLPLDPTQELIFPPELMTMAEKKTQKTRIFGSDR MTWISPVTLKELLEAKVKYPQAPVVMGNTSVGPDMKFKGIFHPVIISPDRIEELSVVNYT DNGLTLGAAVSLAEVKDILANVTRKLPEEKTQMYHALLKHLETLAGPQIRNMASLGGHIV SRHPDSDLNPLLAVGNCTLNLLSKEGRRQIPLNEQFLRKCPSADLKPEEILISVNIPYSR KWEFVSAFRQAQRQQNALAIVNSGMRVCFGKGDGIIRELSIAYGGVGPTTILANNSCQKL IGRPWNEEMLDAACRLILDEVSLPGSAPGGRVEFKRTLIVSFLFKFYLEVSQILKGMDLV HYPSLASKYESALEDLHSRHYWSTLKYQNADLKQLSQDPIGHPIMHLSGIKHATGEAIYC DDMPVVDRELFLTFVTSSRAHAKIVSIDVSAALSLPGVVDILTGEHLPGINTTFGFLTDA DQLLSTDEVSCVGQLVCAVIADSEVQARRAAQQVKIVYQDLEPVILTIEEAIQNKSFFEP ERKLEYGNVDEAFKMVDQILEGEIHMGGQEHFYMETQSMLVVPKGEDREIDVYVSAQFPK YIQDITASVLKVSANKVMCHVKRVGGAFGGKVTKTGVLAAITAFAANKHGRPVRCILERG EDILITGGRHPYLGKYKAGFMNDGRILALDMEHYNNAGAFLDESLFVIEMGLLKLENAYK FPNLRCRGWACRTNLPSNTALRGFGFPQAGLITEACITEVAAKCGLPPEKVRMINMYKEI DQTPYKQEINTKNLTQCWKECMATSSYTLRKAAVEKFNSENYWKKKGLAMVPLKYPIGLG SVAAGQAAALVHIYLDGSVLVTHGGIEMGQGVHTKMIQVVSRELRMPLSSIHLRGTSTET IPNTNPSGGSVVADLNGLAVKDACQTLLKRLKPIISKNPKGTWKDWAQAAFNESISLSAT GYFRGYESNINWETGEGHPFEYFVYGAACSEVEIDCLTGAHKNIRTDIVMDVGYSINPAL DVGQIEGAFIQGMGLYTIEELNYSPQGVLYTRGPNQYKIPAICDIPMELHISFLPPSENS NTLYSSKGLGESGIFLGCSVFFAIHDAIRAARQERGLPGPLRLNSPLTPEKIRMACEDKF TKMIPRDEPGSYVPWSVPI |
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| External Links | |||||||||||
| GenBank ID Protein | CAA60701.1 | ||||||||||
| UniProtKB/Swiss-Prot ID | P48034 | ||||||||||
| UniProtKB/Swiss-Prot Entry Name | AOXA_BOVIN | ||||||||||
| PDB IDs | Not Available | ||||||||||
| GenBank Gene ID | X87251 | ||||||||||
| GeneCard ID | AOX1 | ||||||||||
| GenAtlas ID | Not Available | ||||||||||
| HGNC ID | Not Available | ||||||||||
| References | |||||||||||
| General References | Not Available | ||||||||||