| Identification |
|---|
| BMDB Protein ID
| BMDBP00678 |
| Secondary Accession Numbers
| None |
| Name
| Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform |
| Synonyms
|
Not Available
|
| Gene Name
| PPP3CA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calmodulin binding |
| Specific Function
| Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:15967565, PubMed:1715244, PubMed:1328240, PubMed:16411749). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (By similarity). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (By similarity). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (By similarity). Dephosphorylates heat shock protein HSPB1 (PubMed:1328240). Dephosphorylates and activates transcription factor NFATC1 (By similarity). Dephosphorylates and inactivates transcription factor ELK1 (By similarity). Dephosphorylates DARPP32 (By similarity). May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| Not Available |
| SNPs
| PPP3CA |
| Gene Sequence
|
>1566 bp
ATGTCCGAGCCCAAGGCAATTGATCCCAAGTTGTCGACGACCGACAGGGTGGTGAAAGCT
GTCCCATTTCCTCCAAGTCACCGGCTTACGGCAAAAGAAGTGTTTGATAATGATGGGAAA
CCTCGTGTGGATATCTTAAAGGCACATCTCATGAAGGAGGGCAGGCTCGAAGAGACTGTC
GCATTGAGAATAATAACAGAGGGGGCTTCAATTCTTCGACAGGAAAAAAACTTGCTGGAT
ATTGATGCTCCAGTCACAGTTTGTGGGGACATCCATGGACAATTCTTTGACTTGATGAAA
CTCTTTGAAGTGGGGGGATCTCCTGCCAACACTCGCTACCTCTTCTTAGGGGACTATGTT
GACAGAGGGTACTTCAGTATCGAATGTGTGCTGTATTTGTGGGCTTTGAAAATTCTTTAC
CCCAAAACACTGTTTTTACTTCGTGGAAATCATGAATGTAGACATCTAACAGAGTATTTC
ACATTTAAACAAGAATGTAAAATAAAGTATTCAGAACGCGTATATGATGCCTGCATGGAT
GCCTTTGACTGCCTGCCCCTGGCTGCCCTGATGAACCAGCAGTTCCTGTGTGTACACGGC
GGTTTGTCTCCAGAGATAAACACTTTAGATGATATCAGAAAATTAGACCGATTCAAAGAA
CCACCTGCTTATGGACCTATGTGTGATATCCTGTGGTCAGACCCGCTGGAAGATTTTGGA
AACGAGAAGACTCAGGAACATTTCACTCACAACACAGTCAGGGGGTGTTCATACTTCTAC
AGTTACCCGGCTGTATGTGAATTCTTGCAGCACAATAACTTGTTATCTATCCTCCGAGCT
CATGAAGCCCAAGATGCAGGGTACCGCATGTACAGGAAAAGCCAAACAACAGGCTTCCCC
TCTCTCATTACAATTTTTTCAGCACCAAATTACTTAGATGTATACAATAACAAAGCTGCA
GTATTGAAGTATGAGAACAATGTCATGAATATCAGGCAATTCAACTGTTCTCCTCATCCA
TACTGGCTTCCAAATTTCATGGATGTTTTCACCTGGTCCCTGCCGTTTGTTGGGGAAAAA
GTGACTGAGATGCTGGTAAATGTCCTCAACATATGCTCAGACGATGAACTAGGGTCAGAA
GAAGATGGATTTGATGGAGCAACGGCTGCAGCCAGGAAGGAGGTGATAAGAAATAAGATC
CGAGCCATTGGCAAGATGGCCAGAGTGTTCTCGGTTCTCAGAGAAGAGAGTGAGAGTGTG
CTGACGCTGAAAGGGCTGACGCCCACAGGCATGCTCCCCAGCGGCGTGCTTTCTGGAGGG
AAACAAACCCTGCAAAGCGCTACTGTTGAGGCTATTGAGGCTGATGAAGCTATCAAAGGA
TTTTCACCACAACATAAGATCACTAGCTTCGAGGAGGCCAAGGGCTTAGACCGAATTAAT
GAGAGGATGCCACCTCGCAGAGATGCCATGCCCTCTGATGCCAACCTTAACTCCATCAAC
AAGGCTCTCGCCTCAGAGACTAACGGCACGGACAGCAATGGCAGTAATAGCAGCAATATC
CAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 521 |
| Molecular Weight
| 58672.0 |
| Theoretical pI
| 5.66 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEETV
ALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYV
DRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMD
AFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFG
NEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFP
SLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEK
VTEMLVNVLNICSDDELGSEEDGFDGATAAARKEVIRNKIRAIGKMARVFSVLREESESV
LTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADEAIKGFSPQHKITSFEEAKGLDRIN
ERMPPRRDAMPSDANLNSINKALASETNGTDSNGSNSSNIQ
|
| External Links |
|---|
| GenBank ID Protein
| AAC48473.1 |
| UniProtKB/Swiss-Prot ID
| P48452 |
| UniProtKB/Swiss-Prot Entry Name
| PP2BA_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| U33868 |
| GeneCard ID
| PPP3CA |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
