| Identification |
|---|
| BMDB Protein ID
| BMDBP00679 |
| Secondary Accession Numbers
| None |
| Name
| DNA oxidative demethylase ALKBH2 |
| Synonyms
|
Not Available
|
| Gene Name
| ALKBH2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Replication, recombination and repair |
| Specific Function
| Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| Not Available |
| SNPs
| ALKBH2 |
| Gene Sequence
|
>837 bp
ATGGACAGATTCCTGGTAAAGGGGGCTGTTGGGAGCCTTAAGAGAAGGATGGAACAAGAG
CAGACTGGAGGAGGCCCAGCAGGGTTGGCAGAAGAGGAGGGAAACAGCAAGAAAAATCCC
AGGAGAGCAGCCCCAGGGAATGGAGTTGACTCAGCAGGCCTCACCTGGGGGCGCATTCGA
GCGGAGGGCCTGAACTGCGATTACACAATCCTGTTTGGCAAAGCCGAAGCAGACGAGATT
TTCCAAGAGTTGGAGAAAGAAGTGGAATATTTTACAGGTGCGCTGGCCAGGGTCCAGGTG
TTCGGGAAGTGGCACAGTGTCCCAAGGAAGCAGGCGACCTACGGCGACACTGGGCTAACC
TACACGTTTTCAGGCCTCACTCTGTCTCCGAAGCCCTGGATCCCCGTTCTGGAGCGTGTA
CGGGATCGTGTTTCTCTGGTGACTGGACAGACCTTCAACTTTGTGCTCATCAACAGGTAC
AAAGACGGCCAGGACCACATTGGCGAGCACAGGGATGATGAGAGAGAACTGGCTCTCGGG
AGCCCAATCGCCTCTGTCTCCTTTGGGGCCTGCAGAGACTTCGTCTTCCGGCATAAGGAT
TCCCGGGGGAAGCACCCGTCCCGGAGGCTGGAGGTGGTCAGGCTCCAGCTGGCCCATGGC
AGCTTACTCATGATGAACCACCCGACCAACACTCACTGGTACCACAGTCTCCCAGTCCGA
AAGAAGGTTCTGGCTCCCCGGGTCAATCTGACATTTCGGAAAATCCTGCCTACTACAAAG
CGAACAACATTGTTAACAGCAAGCGCTTCTGTTGGCTCCTTCGCTCTCCACTCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 278 |
| Molecular Weight
| 31053.0 |
| Theoretical pI
| 10.43 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2
MDRFLVKGAVGSLKRRMEQEQTGGGPAGLAEEEGNSKKNPRRAAPGNGVDSAGLTWGRIR
AEGLNCDYTILFGKAEADEIFQELEKEVEYFTGALARVQVFGKWHSVPRKQATYGDTGLT
YTFSGLTLSPKPWIPVLERVRDRVSLVTGQTFNFVLINRYKDGQDHIGEHRDDERELALG
SPIASVSFGACRDFVFRHKDSRGKHPSRRLEVVRLQLAHGSLLMMNHPTNTHWYHSLPVR
KKVLAPRVNLTFRKILPTTKRTTLLTASASVGSFALHS
|
| External Links |
|---|
| GenBank ID Protein
| AAX46420.1 |
| UniProtKB/Swiss-Prot ID
| Q58DM4 |
| UniProtKB/Swiss-Prot Entry Name
| ALKB2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT021573 |
| GeneCard ID
| ALKBH2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
