| Identification |
|---|
| BMDB Protein ID
| BMDBP00691 |
| Secondary Accession Numbers
| None |
| Name
| Prolyl 4-hydroxylase subunit alpha-3 |
| Synonyms
|
Not Available
|
| Gene Name
| P4HA3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in iron ion binding |
| Specific Function
| Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. |
| Pathways
|
- Arginine and Proline Metabolism
- Succinate Signalling
|
| Reactions
|
| L-Proline + Oxoglutaric acid + Oxygen → Hydroxyproline + Succinic acid + Carbon dioxide |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 15 |
| Locus
| Not Available |
| SNPs
| P4HA3 |
| Gene Sequence
|
>1635 bp
ATGGGCCCCGCAGCGCGGCTGGCGGCGCTGTTGGCGGTGCTGGCGTTCCGGGCAGGGGAC
CCAGCCGAGGTCGCGGCGCGCGGGGACACGTTCTCGGCGCTGACCAGTGTGGCGCGCGCC
CTGGCGCCCGAGCGCCGGCTGCTGGGACTGCTGCGGCGCTACCTGCGCGGGGAGGAGGCG
CGGCTGCGGGACCTGACCAGATTCTATCACAAGGTGCTATCTTTACATGAAGATTCAGCA
ACCCCTGTGTCTAACCCTCTGCTTGCATTTACTCTCATCAAACGCCTACAGTCTGACTGG
AAGAATGTGGTACATAGTCTGGAGGCCAGTGAGAACATCCGAGCTCTCAAGGATGGTTAT
GAGAGGGTGGAGCAGGACCTGCCAGCCTTTGAGGACCTCGAGGGAGCAGCAAGGGCCCTG
ATGCGGCTGCAGGACGTGTACATGCTCAATGTGAAGGGACTTGCCCGAGGCGTCTTCCAG
AGAGTCACAGGCTCTGCTGTCACTGACTTGTATAGTCCCAGGCGACTTTTCTCCCTCACC
GGGGATGACTGCTTCCAAGTTGGCAAGGTGGCCTATGACATGGGGGATTACTACCATGCC
ATTCCATGGCTGGAGGAGGCCGTCAGTCTCTTCCGAGGCTCTTATGGAGAATGGAAGACA
GAGGATGAGGCAAGTCTTGAGGATGCCTTGGATCACCTGGCCTTCGCCTATTTCCAGGCA
GGAAATGTTTTGTGTGCCCTCAACCTTTCCCGGGAGTTTCTTCTGTACAGCCCAGATAAT
AAAAGGGTGGCCAGAAATGTCTTGAAGTATGAAAAGCTCTTGGCAGAGAGCCCTAACCAG
GCTGTAGCAGAGACTGTCATGCAGAGACCCAATGTGCCCCACCTGCAGACCAGGGACACC
TACGAGGGGTTATGTCAGACCCTGGGTTCCCAGCCTACTCACTACCGGATCCCCAGCCTC
TACTGCTCCTATGAGACCAGTTCCAGTCCTTACCTGCTGCTCCAGCCTGTGCGGAAGGAG
GTCATCCACCTGGAGCCCTATGTTGTTCTCTACCATGACTTTGTCAGTGACGCCGAGGCT
CAGACGATCAGAGGGCTTGCGGAACCATGGTTACAGAGATCCGTGGTGGCGTCAGGTGAA
AAGCAGTTACCAGTGGAGTACCGCATCAGCAAGAGTGCCTGGCTGAAGGACACTGTTGAC
CCAGTGCTGGTGACCCTTGACCATCGCATTGCTGCCCTCACGGGCCTTGATGTCCAGCCT
CCCTACGCAGAGTATCTCCAGGTGGTGAACTATGGAATTGGAGGGCACTATGAGCCTCAC
TTTGACCATGCTACGTCACCAAGCAGCCCACTGTACAGAATGAACTCTGGGAACCGGGTC
GCAACATTTATGATCTATTTGAGCTCGGTGGAAGCCGGAGGAGCCACAGCCTTCATCTAC
GGCAACTTCAGCGTTCCTGTGGTCAAGAATGCAGCACTCTTTTGGTGGAACCTGCATAGG
AGTGGTGAAGGGGATGGTGACACACTTCATGCTGCCTGCCCTGTCCTGGTAGGAGATAAA
TGGGTGGCCAACAAGTGGATACACGAGTATGGACAGGAATTCCGCAGACCCTGCAGCTCG
AGACCTGAAGACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 544 |
| Molecular Weight
| 61023.0 |
| Theoretical pI
| 6.31 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Prolyl 4-hydroxylase subunit alpha-3
MGPAARLAALLAVLAFRAGDPAEVAARGDTFSALTSVARALAPERRLLGLLRRYLRGEEA
RLRDLTRFYHKVLSLHEDSATPVSNPLLAFTLIKRLQSDWKNVVHSLEASENIRALKDGY
ERVEQDLPAFEDLEGAARALMRLQDVYMLNVKGLARGVFQRVTGSAVTDLYSPRRLFSLT
GDDCFQVGKVAYDMGDYYHAIPWLEEAVSLFRGSYGEWKTEDEASLEDALDHLAFAYFQA
GNVLCALNLSREFLLYSPDNKRVARNVLKYEKLLAESPNQAVAETVMQRPNVPHLQTRDT
YEGLCQTLGSQPTHYRIPSLYCSYETSSSPYLLLQPVRKEVIHLEPYVVLYHDFVSDAEA
QTIRGLAEPWLQRSVVASGEKQLPVEYRISKSAWLKDTVDPVLVTLDHRIAALTGLDVQP
PYAEYLQVVNYGIGGHYEPHFDHATSPSSPLYRMNSGNRVATFMIYLSSVEAGGATAFIY
GNFSVPVVKNAALFWWNLHRSGEGDGDTLHAACPVLVGDKWVANKWIHEYGQEFRRPCSS
RPED
|
| External Links |
|---|
| GenBank ID Protein
| BAD18888.1 |
| UniProtKB/Swiss-Prot ID
| Q75UG4 |
| UniProtKB/Swiss-Prot Entry Name
| P4HA3_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB126035 |
| GeneCard ID
| P4HA3 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
