Showing Protein Acidic mammalian chitinase (BMDBP00702)
| Identification | |||
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| BMDB Protein ID | BMDBP00702 | ||
| Secondary Accession Numbers |
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| Name | Acidic mammalian chitinase | ||
| Synonyms | Not Available | ||
| Gene Name | CHIA | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Involved in cation binding | ||
| Specific Function | Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding (By similarity). | ||
| Pathways | Not Available | ||
| Reactions |
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| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 3 | ||
| Locus | Not Available | ||
| SNPs | CHIA | ||
| Gene Sequence |
>1419 bp ATGGCAAAACTTATTTTCCTCACAGGTCTGGCCTTTCTGCTGAATGCTCAGCTAGGTTCT GCCTACCAGCTGGTATGCTACTTCTCTAACTGGGCCCAGTACCGTCCAGGCCTGGGAAGC TTCAAGCCTGACAACATCGACCCCTGCCTCTGCACTCACCTGATCTATGCCTTCGCTGGG ATGAGTAACAGTGAGATCACCACCATTGAATGGAATGATGTGGCTCTCTATAGTTCTTTC AATGACCTGAAAAAAAAGAACAGCCAGCTGAAAATTCTCCTGGCCATTGGAGGCTGGAAC TTTGGAACTGCCCCTTTCACTGCTATGGTTGCCACTCCGGAGAACCGCAAGACTTTCATT TCTTCAGTCATCAAATTCCTACACCAGTATGGATTTGACGGGCTGGATTTTGATTGGGAG TACCCTGGCTTTCGTGGAAGCCCTTCTCAGGACAAGCATCTCTTCACTGTCTTAGTGCAG GAAACACGTGAAGCTTTTGAACAGGAAGCCAAGCAAACCAACAAGCCCAGGCTGCTGGTC ACCGCTGCAGTAGCTGCTGGCATCTCTAATATCCAGGCTGGCTATGAGATTCCCCAGCTA TCCCAGTACCTGGACTTCATCCATGTCATGACCTATGACTTCCATGGCTCCTGGGAAGGC TACACAGGAGAGAACAGCCCTCTCTACAAATACCCAACTGACACTGGCAGCAATACTTAC CTCAATGTGGAATACGCCATGAACTACTGGAAGAAAAATGGGGCCCCGGCTGAGAAGCTC ATCATTGGATTCCCTGCCTACGGACACAATTTCATCCTAAGAGACGCTTCCAACAATGGT ATCGGTGCCCCCACTTCTGGAGCTGGTCCTGCCGGGCCCTACACCAGGGAGGCTGGGTTC TGGGCCTACTATGAGATCTGTGCCTTCCTGAAAGATGGAGCCACTGAGGCATGGGATGAC TCTCAGAATGTGCCCTATGCCTACAAGGGCACTGAGTGGGTTGGTTATGACAATGTTAAC AGCTTCAGAATCAAGGCTCAGTGGCTTAAGGAGAACAACTTTGGAGGTGCCATGGTCTGG GCCATTGACCTGGATGATTTCACAGGCACTTTCTGCAACCAGGGCAAGTTCCCCCTGATA AATACCTTGAAGGATGCTCTTGGCCTGAAGAGTGCAACCTGTAATGCCTCCACGCAGTCC AGTGAGCCCAACAGCAGTCCTGGAAACGAAAGTGGGAGTGGAAATAAGAGCAGCAGCTCC GAGGGTAGAGGATACTGTGCTGGCAAAGCTGATGGCCTCTACCCAGTGGCGGATAACAGA AATGCCTTCTGGAACTGCGTAAATGGAATCACATACAAACAGAATTGCCTGACTGGGCTT GTCTTTGACACCAGCTGTCACTGCTGCAACTGGGCATAA |
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| Protein Properties | |||
| Number of Residues | 472 | ||
| Molecular Weight | 52129.0 | ||
| Theoretical pI | 5.25 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
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| Transmembrane Regions | Not Available | ||
| Protein Sequence |
>Acidic mammalian chitinase MAKLIFLTGLAFLLNAQLGSAYQLVCYFSNWAQYRPGLGSFKPDNIDPCLCTHLIYAFAG MSNSEITTIEWNDVALYSSFNDLKKKNSQLKILLAIGGWNFGTAPFTAMVATPENRKTFI SSVIKFLHQYGFDGLDFDWEYPGFRGSPSQDKHLFTVLVQETREAFEQEAKQTNKPRLLV TAAVAAGISNIQAGYEIPQLSQYLDFIHVMTYDFHGSWEGYTGENSPLYKYPTDTGSNTY LNVEYAMNYWKKNGAPAEKLIIGFPAYGHNFILRDASNNGIGAPTSGAGPAGPYTREAGF WAYYEICAFLKDGATEAWDDSQNVPYAYKGTEWVGYDNVNSFRIKAQWLKENNFGGAMVW AIDLDDFTGTFCNQGKFPLINTLKDALGLKSATCNASTQSSEPNSSPGNESGSGNKSSSS EGRGYCAGKADGLYPVADNRNAFWNCVNGITYKQNCLTGLVFDTSCHCCNWA |
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| External Links | |||
| GenBank ID Protein | BAB71805.1 | ||
| UniProtKB/Swiss-Prot ID | Q95M17 | ||
| UniProtKB/Swiss-Prot Entry Name | CHIA_BOVIN | ||
| PDB IDs | Not Available | ||
| GenBank Gene ID | AB051629 | ||
| GeneCard ID | CHIA | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||