| Identification |
|---|
| BMDB Protein ID
| BMDBP00724 |
| Secondary Accession Numbers
| None |
| Name
| V-type proton ATPase subunit d 1 |
| Synonyms
|
Not Available
|
| Gene Name
| ATP6V0D1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| Not Available |
| SNPs
| ATP6V0D1 |
| Gene Sequence
|
>1056 bp
ATGTCGTTCTTCCCGGAGCTTTACTTCAACGTGGACAATGGCTACTTGGAGGGACTGGTG
CGCGGCCTGAAGGCTGGGGTGCTCAGCCAGGCGGACTACCTCAACCTGGTGCAGTGCGAG
ACGCTCGAGGACCTGAAGCTGCACCTGCAGAGCACTGACTATGGCAACTTCCTGGCCAAT
GAGGCTTCGCCACTGACAGTGTCCGTCATTGATGACCGGCTCAAGGAGAAGATGGTGGTG
GAGTTCCGTCACATGAGGAACCATGCGTATGAGCCACTCGCCAGCTTCCTGGACTTCATT
ACTTACAGCTACATGATCGACAACGTAATCCTGCTCATCACGGGCACGCTGCACCAGCGC
TCTATCGCCGAGCTTGTGCCTAAGTGCCACCCGCTTGGCAGTTTCGAGCAGATGGAGGCC
GTGAACATCGCACAGACACCCGCCGAGCTCTACAATGCTATTCTGGTGGACACGCCCCTG
GCGGCTTTTTTCCAGGACTGCATCTCAGAGCAGGACCTCGATGAGATGAACATCGAGATC
ATCCGCAACACGCTGTACAAGGCCTACCTGGAGTCCTTCTACAAGTTCTGCACCCTGCTG
GGCGGGACCACGGCCGACGCCATGTGCCCCATCCTGGAGTTTGAAGCAGACCGCCGCGCC
TTCATCATCACCATTAACTCCTTCGGCACAGAGCTGTCCAAGGAGGACCGTGCCAAGCTC
TTCCCGCACTGTGGACGGCTCTACCCGGAGGGCCTGGCCCAGCTGGCTCGAGCCGACGAC
TATGAGCAGGTCAAGAACGTGGCCGACTACTACCCGGAGTACAAGCTGCTTTTCGAAGGT
GCGGGCAGCAACCCTGGAGACAAGACCCTGGAGGACCGATTCTTCGAGCACGAGGTGAAA
CTGAACAAGTTGGCCTTTCTGAACCAGTTCCACTTTGGTGTTTTCTATGCCTTTGTGAAG
CTCAAGGAGCAGGAGTGTCGCAACATTGTGTGGATTGCCGAGTGCATCGCCCAACGCCAC
CGGGCCAAGATTGACAACTACATCCCTATCTTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 351 |
| Molecular Weight
| 40329.0 |
| Theoretical pI
| 4.63 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>V-type proton ATPase subunit d 1
MSFFPELYFNVDNGYLEGLVRGLKAGVLSQADYLNLVQCETLEDLKLHLQSTDYGNFLAN
EASPLTVSVIDDRLKEKMVVEFRHMRNHAYEPLASFLDFITYSYMIDNVILLITGTLHQR
SIAELVPKCHPLGSFEQMEAVNIAQTPAELYNAILVDTPLAAFFQDCISEQDLDEMNIEI
IRNTLYKAYLESFYKFCTLLGGTTADAMCPILEFEADRRAFIITINSFGTELSKEDRAKL
FPHCGRLYPEGLAQLARADDYEQVKNVADYYPEYKLLFEGAGSNPGDKTLEDRFFEHEVK
LNKLAFLNQFHFGVFYAFVKLKEQECRNIVWIAECIAQRHRAKIDNYIPIF
|
| External Links |
|---|
| GenBank ID Protein
| AAA64520.1 |
| UniProtKB/Swiss-Prot ID
| P61420 |
| UniProtKB/Swiss-Prot Entry Name
| VA0D1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| J04204 |
| GeneCard ID
| ATP6V0D1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
