| Identification |
|---|
| BMDB Protein ID
| BMDBP00730 |
| Secondary Accession Numbers
| None |
| Name
| ATP synthase subunit alpha, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| ATP5F1A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites. Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 24 |
| Locus
| Not Available |
| SNPs
| ATP5F1A |
| Gene Sequence
|
>1662 bp
GAGCTGCGAAGATGCTGTCCGTGCGCGTCGCCGCGGCGGTGGCCCGCGCCCTCCCTCGGC
GAGCGGGGCTGGTCTCCAAAAATGCTTTGGGATCATCCTTCATTGCTGCAAGGAACCTGC
ATGCCTCTAACTCTCGTCTGCAGAAGACCGGCACTGCTGAGGTGTCCTCTATTCTTGAAG
AGCGTATTCTTGGAGCTGATACCTCTGTTGACCTTGAAGAGACTGGGCGTGTTTTAAGTA
TTGGTGATGGTATTGCTCGGGTACATGGGCTAAGAAATGTTCAAGCAGAAGAAATGGTAG
AGTTTTCTTCAGGTTTAAAGGGTATGTCTTTGAACTTGGAGCCTGACAATGTTGGTGTTG
TCGTGTTTGGAAATGATAAACTTATTAAGGAAGGAGATATTGTGAAGAGAACTGGGGCTA
TTGTAGATGTTCCAGTCGGCGAGGAGCTGCTGGGTCGTGTAGTTGATGCCCTTGGTAATG
CCATTGATGGAAAGGGTCCAATTGGTTCCAAGGCCCGAAGACGAGTTGGCTTGAAAGCCC
CTGGGATCATTCCTCGAATCTCTGTGAGGGAACCAATGCAAACTGGCATTAAGGCTGTGG
ATAGCTTGGTGCCGATTGGTCGTGGTCAGCGTGAGCTGATTATTGGTGACCGACAGACTG
GCAAAACGTCAATTGCAATTGACACAATCATTAACCAGAAACGATTCAATGATGGAACTG
ATGAAAAGAAGAAGCTGTACTGTATCTATGTTGCTATTGGTCAAAAGAGATCCACTGTTG
CCCAGTTGGTGAAGAGACTTACAGATGCAGATGCCATGAAGTATACCATTGTGGTTTCAG
CTACTGCTTCAGATGCTGCCCCACTTCAGTACTTGGCTCCTTATTCTGGATGTTCAATGG
GAGAATATTTTAGGGATAATGGCAAACACGCTTTGATCATTTATGATGACTTATCCAAAC
AGGCGGTTGCTTATCGTCAGATGTCTCTGCTGCTCCGCCGACCCCCTGGTCGTGAGGCCT
ATCCTGGTGATGTATTCTACCTGCACTCCCGACTCCTGGAGAGAGCAGCTAAAATGAACG
ATGCTTTTGGTGGTGGCTCCTTGACTGCTCTACCAGTCATCGAAACACAAGCTGGTGATG
TGTCTGCTTACATTCCAACAAATGTCATTTCCATCACTGACGGACAGATCTTCTTGGAAA
CAGAATTGTTCTACAAAGGTATCCGCCCTGCCATTAATGTTGGTTTGTCTGTGTCCCGTG
TCGGATCTGCTGCCCAAACCAGGGCCATGAAACAGGTGGCAGGTACTATGAAACTGGAGT
TGGCTCAGTATCGTGAGGTTGCTGCTTTTGCCCAGTTCGGTTCTGACCTTGATGCTGCCA
CTCAACAACTCTTGAGTCGTGGTGTGCGTTTGACTGAGCTGCTCAAGCAGGGACAGTATT
CTCCCATGGCTATTGAAGAGCAAGTGGCTGTTATCTATGCGGGTGTCAGGGGGTATCTTG
ACAAGCTGGAGCCCAGCAAGATCACAAAATTTGAGAATGCTTTCTTGTCTCACGTTATCA
GCCAACATCAGGCCCTGTTGAGCAAAATCAGGACCGATGGAAAGATCTCAGAAGAGTCAG
ATGCAAAGCTGAAAGAGATTGTAACAAACTTCTTGGCTGGAT
|
| Protein Properties |
|---|
| Number of Residues
| 553 |
| Molecular Weight
| 59720.0 |
| Theoretical pI
| 9.64 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>ATP synthase subunit alpha, mitochondrial
MLSVRVAAAVARALPRRAGLVSKNALGSSFIAARNLHASNSRLQKTGTAEVSSILEERIL
GADTSVDLEETGRVLSIGDGIARVHGLRNVQAEEMVEFSSGLKGMSLNLEPDNVGVVVFG
NDKLIKEGDIVKRTGAIVDVPVGEELLGRVVDALGNAIDGKGPIGSKARRRVGLKAPGII
PRISVREPMQTGIKAVDSLVPIGRGQRELIIGDRQTGKTSIAIDTIINQKRFNDGTDEKK
KLYCIYVAIGQKRSTVAQLVKRLTDADAMKYTIVVSATASDAAPLQYLAPYSGCSMGEYF
RDNGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDAFG
GGSLTALPVIETQAGDVSAYIPTNVISITDGQIFLETELFYKGIRPAINVGLSVSRVGSA
AQTRAMKQVAGTMKLELAQYREVAAFAQFGSDLDAATQQLLSRGVRLTELLKQGQYSPMA
IEEQVAVIYAGVRGYLDKLEPSKITKFENAFLSHVISQHQALLSKIRTDGKISEESDAKL
KEIVTNFLAGFEA
|
| External Links |
|---|
| GenBank ID Protein
| AAB59266.1 |
| UniProtKB/Swiss-Prot ID
| P19483 |
| UniProtKB/Swiss-Prot Entry Name
| ATPA_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| M22465 |
| GeneCard ID
| ATP5F1A |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
