| Identification |
|---|
| BMDB Protein ID
| BMDBP00740 |
| Secondary Accession Numbers
| None |
| Name
| V-type proton ATPase 116 kDa subunit a isoform 2 |
| Synonyms
|
Not Available
|
| Gene Name
| ATP6V0A2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| Not Available |
| SNPs
| ATP6V0A2 |
| Gene Sequence
|
>2565 bp
ATGGGGTCCCTGTTCCGGAGCGAGACCATGTGCCTGGCGCAACTCTTCCTGCAGTCCGGC
ACGGCCTACGAGTGCCTCAGCGTCCTGGGCGAGAAGGGCCTGGTCGAGTTCCGAGACCTC
AACCAGAATGTAAGTTCTTTCCAAAGAAAATTTGTTGGTGAGGTGAAGCGATGTGAAGAA
CTGGAGCGAATATTGGCATACTTGGTGCAGGAAATCAATAGAGCGGATATTCCCCTCCCT
GAGGGGGACACCAGTCCTCCGGCACCACCTCTGAAACAAGTGCTGGAAATGCAGGAGCAG
TTGCAGAAGCTGGAGGTTGAGCTGAGAGAGGTCACTAAGAATAAGGAGAAGCTGAGGAAG
AACCTGCTGGAGCTAATTGAGTACACCCACATGCTGCGAGTGACCAAGACTTTCGTCAAG
CGCAATGTGGAGTTCGAACCCACTTACGAAGAGTTCCCTCCCTTGGAGAACGAGTCTTTG
TTGGACTACAGCTGTATGCAGAGGCTGGGAGCAAAACTGGGATTTGTATCTGGCCTAATT
AACCAAGGAAAAGTTGAAGCATTTGAAAAAATGTTGTGGAGGGTCTGTAAAGGGTACACC
ATCGTGACCTATGCAGAGCTGGATGAGCCCCTGGAAGACCCTGAAACAGGAGAAGTCATA
AAATGGTATGTCTTTTTGATATCCTTTTGGGGAGAGCAGATTGGCCACAAGGTTAAGAAG
ATATGTGATTGTTACCACTGCCACGTTTACCCCTACCCCAACACAGCCGAGGAGCGCAGA
GAGATCCAGGAGGGACTGAATACCCGGATTCAAGATCTTTACACCGTGCTTCACAAGACC
GAGGACTATTTAAGGCAAGTGCTGTGTAAAGCCGCCGAGTCGGTCTACAGCCGCGTGATC
CAGGTGAAGAAGATGAAAGCCATTTACCACATGCTGAACATGTGCAGCTTCGACGTGACC
AACAAGTGCCTCATCGCCGAGGTCTGGTGTCCTGAGGCTGATTTGCACGAGCTGCGAAGG
GCGCTGGAGGAGGGCTCGAGAGAGAGCGGTGGTACGATCCCCTCATTCATGAACACAATC
CCAACAAAAGAAACTCCCCCAACCCTGATCCGCACCAACAAATTCACCGAGGGCTTTCAG
AACATTGTGGATGCCTACGGGGTCGGGAGCTACCAAGAGGTGAACCCAGCTCTCTTCACC
ATCATCACTTTCCCCTTTTTATTTGCCGTGATGTTTGGAGACTTTGGACATGGTTTTGTG
ATGTTCTTATTTGCCCTCCTGTTGGTGTTAAACGAAAATCATCCCAGACTAAATCAGTCA
CAAGAGATCATGCGGATGTTCTTCAATGGTCGCTATATCCTCCTGCTGATGGGGCTGTTC
TCAGTGTACACGGGCCTCATCTACAACGACTGCTTTTCCAAGTCAGTCAACCTCTTCGGC
TCCAGGTGGAACGTGTCTGCCATGTACAGCTCCAGTCACAGCCCAGAGGAGCAGAGGAAG
ATGGTGCTTTGGAATGACAGCATCGTCAGGCACCACAGCGTGTTGCAGTTGGATCCCAGT
GTTCCCGGAGTGTTCCGTGGCCCTTACCCTTTCGGCATTGATCCTATTTGGAACTTAGCC
ACCAATCGTCTCACTTTTCTAAACTCTTTCAAAATGAAGATGTCTGTGATTTTAGGGATT
ACTCACATGACTTTTGGAGTCATTCTGGGAATATTTAACCACTTACATTTCAGGAAGAAG
TTCAATATTTGTCTGGTTTCCATACCAGAACTGCTCTTCATGCTCTGCATCTTTGGATAC
CTTATATTTATGATCATCTATAAGTGGCTGGTTTATTCAGCTGAAACCTCCAGAACTGCT
CCTAGCATTCTGATTGAATTTATTAGCATGTTTTTGTTCCTGGCTAGTGACACAGGTGGT
CTTTACCCAGGGCAGGAGCATGTCCAGAGGCTGCTGCTGCTCATCACCGTGTTGTCAGTC
CCCGTGCTTTTCTTGGGAAAACCACTCTTTCTGCTGTGGCTGCACAGGGGGCGCAGTTGT
TTTGGGGTTGGCAGGAGTGGCTACACACTTGTAAGGAAAGATAGCGAGGAAGAAGTTTCT
TTGCTGGGAGGCCAAGACATAGAAGAGGGGAACAACCAAATGGAAGATGGATGTAGAGAA
GTGACGTGTGAAGAGTTTGATTTTGGAGAAATATTAATGACCCAAATAATTCATTCCATC
GAGTACTGTCTGGGATGCATCTCTAACACTGCTTCGTACCTGAGGCTCTGGGCACTCAGT
TTGGCTCACGCACAGTTGTCTGAGGTCCTGTGGGCCATGCTGATGCACGTCGGCCTCCGG
GTAGACACAGCCTACGGGGTCTTGGTGCTGCTCCCAGTGATCGCTTTCTTTGCAGTATTG
ACGATTTTCATCCTTTTGATCATGGAAGGGCTTTCTGCATTTCTTCACGCCATCCGCCTC
CACTGGGTAGAATTTCAGAACAAATTCTACGTTGGTGCAGGCACCAAATTTGTTCCTTTT
TCATTCAGATTACTTTCTTCGAAGTTCAGTGATGACCTGGCGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 854 |
| Molecular Weight
| 98010.0 |
| Theoretical pI
| 6.29 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 394-412
- 415-431
- 446-475
- 550-569
- 588-608
- 652-671
- 740-764
- 786-824
|
| Protein Sequence
|
>V-type proton ATPase 116 kDa subunit a isoform 2
MGSLFRSETMCLAQLFLQSGTAYECLSVLGEKGLVEFRDLNQNVSSFQRKFVGEVKRCEE
LERILAYLVQEINRADIPLPEGDTSPPAPPLKQVLEMQEQLQKLEVELREVTKNKEKLRK
NLLELIEYTHMLRVTKTFVKRNVEFEPTYEEFPPLENESLLDYSCMQRLGAKLGFVSGLI
NQGKVEAFEKMLWRVCKGYTIVTYAELDEPLEDPETGEVIKWYVFLISFWGEQIGHKVKK
ICDCYHCHVYPYPNTAEERREIQEGLNTRIQDLYTVLHKTEDYLRQVLCKAAESVYSRVI
QVKKMKAIYHMLNMCSFDVTNKCLIAEVWCPEADLHELRRALEEGSRESGGTIPSFMNTI
PTKETPPTLIRTNKFTEGFQNIVDAYGVGSYQEVNPALFTIITFPFLFAVMFGDFGHGFV
MFLFALLLVLNENHPRLNQSQEIMRMFFNGRYILLLMGLFSVYTGLIYNDCFSKSVNLFG
SRWNVSAMYSSSHSPEEQRKMVLWNDSIVRHHSVLQLDPSVPGVFRGPYPFGIDPIWNLA
TNRLTFLNSFKMKMSVILGITHMTFGVILGIFNHLHFRKKFNICLVSIPELLFMLCIFGY
LIFMIIYKWLVYSAETSRTAPSILIEFISMFLFLASDTGGLYPGQEHVQRLLLLITVLSV
PVLFLGKPLFLLWLHRGRSCFGVGRSGYTLVRKDSEEEVSLLGGQDIEEGNNQMEDGCRE
VTCEEFDFGEILMTQIIHSIEYCLGCISNTASYLRLWALSLAHAQLSEVLWAMLMHVGLR
VDTAYGVLVLLPVIAFFAVLTIFILLIMEGLSAFLHAIRLHWVEFQNKFYVGAGTKFVPF
SFRLLSSKFSDDLA
|
| External Links |
|---|
| GenBank ID Protein
| AAD12058.1 |
| UniProtKB/Swiss-Prot ID
| O97681 |
| UniProtKB/Swiss-Prot Entry Name
| VPP2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF105016 |
| GeneCard ID
| ATP6V0A2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
