Showing Protein V-type proton ATPase 116 kDa subunit a isoform 2 (BMDBP00740)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00740 |
| Secondary Accession Numbers | None |
| Name | V-type proton ATPase 116 kDa subunit a isoform 2 |
| Synonyms | Not Available |
| Gene Name | ATP6V0A2 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Energy production and conversion |
| Specific Function | Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 17 |
| Locus | Not Available |
| SNPs | ATP6V0A2 |
| Gene Sequence |
>2565 bp ATGGGGTCCCTGTTCCGGAGCGAGACCATGTGCCTGGCGCAACTCTTCCTGCAGTCCGGC ACGGCCTACGAGTGCCTCAGCGTCCTGGGCGAGAAGGGCCTGGTCGAGTTCCGAGACCTC AACCAGAATGTAAGTTCTTTCCAAAGAAAATTTGTTGGTGAGGTGAAGCGATGTGAAGAA CTGGAGCGAATATTGGCATACTTGGTGCAGGAAATCAATAGAGCGGATATTCCCCTCCCT GAGGGGGACACCAGTCCTCCGGCACCACCTCTGAAACAAGTGCTGGAAATGCAGGAGCAG TTGCAGAAGCTGGAGGTTGAGCTGAGAGAGGTCACTAAGAATAAGGAGAAGCTGAGGAAG AACCTGCTGGAGCTAATTGAGTACACCCACATGCTGCGAGTGACCAAGACTTTCGTCAAG CGCAATGTGGAGTTCGAACCCACTTACGAAGAGTTCCCTCCCTTGGAGAACGAGTCTTTG TTGGACTACAGCTGTATGCAGAGGCTGGGAGCAAAACTGGGATTTGTATCTGGCCTAATT AACCAAGGAAAAGTTGAAGCATTTGAAAAAATGTTGTGGAGGGTCTGTAAAGGGTACACC ATCGTGACCTATGCAGAGCTGGATGAGCCCCTGGAAGACCCTGAAACAGGAGAAGTCATA AAATGGTATGTCTTTTTGATATCCTTTTGGGGAGAGCAGATTGGCCACAAGGTTAAGAAG ATATGTGATTGTTACCACTGCCACGTTTACCCCTACCCCAACACAGCCGAGGAGCGCAGA GAGATCCAGGAGGGACTGAATACCCGGATTCAAGATCTTTACACCGTGCTTCACAAGACC GAGGACTATTTAAGGCAAGTGCTGTGTAAAGCCGCCGAGTCGGTCTACAGCCGCGTGATC CAGGTGAAGAAGATGAAAGCCATTTACCACATGCTGAACATGTGCAGCTTCGACGTGACC AACAAGTGCCTCATCGCCGAGGTCTGGTGTCCTGAGGCTGATTTGCACGAGCTGCGAAGG GCGCTGGAGGAGGGCTCGAGAGAGAGCGGTGGTACGATCCCCTCATTCATGAACACAATC CCAACAAAAGAAACTCCCCCAACCCTGATCCGCACCAACAAATTCACCGAGGGCTTTCAG AACATTGTGGATGCCTACGGGGTCGGGAGCTACCAAGAGGTGAACCCAGCTCTCTTCACC ATCATCACTTTCCCCTTTTTATTTGCCGTGATGTTTGGAGACTTTGGACATGGTTTTGTG ATGTTCTTATTTGCCCTCCTGTTGGTGTTAAACGAAAATCATCCCAGACTAAATCAGTCA CAAGAGATCATGCGGATGTTCTTCAATGGTCGCTATATCCTCCTGCTGATGGGGCTGTTC TCAGTGTACACGGGCCTCATCTACAACGACTGCTTTTCCAAGTCAGTCAACCTCTTCGGC TCCAGGTGGAACGTGTCTGCCATGTACAGCTCCAGTCACAGCCCAGAGGAGCAGAGGAAG ATGGTGCTTTGGAATGACAGCATCGTCAGGCACCACAGCGTGTTGCAGTTGGATCCCAGT GTTCCCGGAGTGTTCCGTGGCCCTTACCCTTTCGGCATTGATCCTATTTGGAACTTAGCC ACCAATCGTCTCACTTTTCTAAACTCTTTCAAAATGAAGATGTCTGTGATTTTAGGGATT ACTCACATGACTTTTGGAGTCATTCTGGGAATATTTAACCACTTACATTTCAGGAAGAAG TTCAATATTTGTCTGGTTTCCATACCAGAACTGCTCTTCATGCTCTGCATCTTTGGATAC CTTATATTTATGATCATCTATAAGTGGCTGGTTTATTCAGCTGAAACCTCCAGAACTGCT CCTAGCATTCTGATTGAATTTATTAGCATGTTTTTGTTCCTGGCTAGTGACACAGGTGGT CTTTACCCAGGGCAGGAGCATGTCCAGAGGCTGCTGCTGCTCATCACCGTGTTGTCAGTC CCCGTGCTTTTCTTGGGAAAACCACTCTTTCTGCTGTGGCTGCACAGGGGGCGCAGTTGT TTTGGGGTTGGCAGGAGTGGCTACACACTTGTAAGGAAAGATAGCGAGGAAGAAGTTTCT TTGCTGGGAGGCCAAGACATAGAAGAGGGGAACAACCAAATGGAAGATGGATGTAGAGAA GTGACGTGTGAAGAGTTTGATTTTGGAGAAATATTAATGACCCAAATAATTCATTCCATC GAGTACTGTCTGGGATGCATCTCTAACACTGCTTCGTACCTGAGGCTCTGGGCACTCAGT TTGGCTCACGCACAGTTGTCTGAGGTCCTGTGGGCCATGCTGATGCACGTCGGCCTCCGG GTAGACACAGCCTACGGGGTCTTGGTGCTGCTCCCAGTGATCGCTTTCTTTGCAGTATTG ACGATTTTCATCCTTTTGATCATGGAAGGGCTTTCTGCATTTCTTCACGCCATCCGCCTC CACTGGGTAGAATTTCAGAACAAATTCTACGTTGGTGCAGGCACCAAATTTGTTCCTTTT TCATTCAGATTACTTTCTTCGAAGTTCAGTGATGACCTGGCGTGA |
| Protein Properties | |
| Number of Residues | 854 |
| Molecular Weight | 98010.0 |
| Theoretical pI | 6.29 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions |
|
| Protein Sequence |
>V-type proton ATPase 116 kDa subunit a isoform 2 MGSLFRSETMCLAQLFLQSGTAYECLSVLGEKGLVEFRDLNQNVSSFQRKFVGEVKRCEE LERILAYLVQEINRADIPLPEGDTSPPAPPLKQVLEMQEQLQKLEVELREVTKNKEKLRK NLLELIEYTHMLRVTKTFVKRNVEFEPTYEEFPPLENESLLDYSCMQRLGAKLGFVSGLI NQGKVEAFEKMLWRVCKGYTIVTYAELDEPLEDPETGEVIKWYVFLISFWGEQIGHKVKK ICDCYHCHVYPYPNTAEERREIQEGLNTRIQDLYTVLHKTEDYLRQVLCKAAESVYSRVI QVKKMKAIYHMLNMCSFDVTNKCLIAEVWCPEADLHELRRALEEGSRESGGTIPSFMNTI PTKETPPTLIRTNKFTEGFQNIVDAYGVGSYQEVNPALFTIITFPFLFAVMFGDFGHGFV MFLFALLLVLNENHPRLNQSQEIMRMFFNGRYILLLMGLFSVYTGLIYNDCFSKSVNLFG SRWNVSAMYSSSHSPEEQRKMVLWNDSIVRHHSVLQLDPSVPGVFRGPYPFGIDPIWNLA TNRLTFLNSFKMKMSVILGITHMTFGVILGIFNHLHFRKKFNICLVSIPELLFMLCIFGY LIFMIIYKWLVYSAETSRTAPSILIEFISMFLFLASDTGGLYPGQEHVQRLLLLITVLSV PVLFLGKPLFLLWLHRGRSCFGVGRSGYTLVRKDSEEEVSLLGGQDIEEGNNQMEDGCRE VTCEEFDFGEILMTQIIHSIEYCLGCISNTASYLRLWALSLAHAQLSEVLWAMLMHVGLR VDTAYGVLVLLPVIAFFAVLTIFILLIMEGLSAFLHAIRLHWVEFQNKFYVGAGTKFVPF SFRLLSSKFSDDLA |
| External Links | |
| GenBank ID Protein | AAD12058.1 |
| UniProtKB/Swiss-Prot ID | O97681 |
| UniProtKB/Swiss-Prot Entry Name | VPP2_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | AF105016 |
| GeneCard ID | ATP6V0A2 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |