| Identification |
|---|
| BMDB Protein ID
| BMDBP00758 |
| Secondary Accession Numbers
| None |
| Name
| V-type proton ATPase subunit G 1 |
| Synonyms
|
Not Available
|
| Gene Name
| ATP6V1G1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in proton transport |
| Specific Function
| Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| Not Available |
| SNPs
| ATP6V1G1 |
| Gene Sequence
|
>357 bp
ATGGCCAGTCAGTCGCAGGGCATCCAGCAGCTGCTCCAGGCGGAGAAACGGGCCGCCGAG
AAGGTGTCCGAGGCCCGCAAGCGAAAGAACCGGAGGCTGAAGCAGGCTAAAGAAGAAGCC
CAGGCTGAAGTTGAACAGTACCGCCTGCAGAGGGAGAAGGAGTTCAAGGCCAAGGAAGCT
GCGGCTCTGGGATCCCATGGTAGTTGCAGCACTGAAGTAGAGAAGGACACCCAGGAGAAG
ATGACCATCCTTCAAACCTACTTCCAGCAGAACAGGGATGAAGTCTTGGATAACCTCTTG
GCCTTTGTCTGCGACATCCGGCCGGAAATCCATGAGAACTACCGCATAAATGGATAG
|
| Protein Properties |
|---|
| Number of Residues
| 118 |
| Molecular Weight
| 13682.0 |
| Theoretical pI
| 8.21 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 6-31
- 67-86
- 98-117
- 137-158
- 164-184
- 196-222
|
| Protein Sequence
|
>V-type proton ATPase subunit G 1
MASQSQGIQQLLQAEKRAAEKVSEARKRKNRRLKQAKEEAQAEVEQYRLQREKEFKAKEA
AALGSHGSCSTEVEKDTQEKMTILQTYFQQNRDEVLDNLLAFVCDIRPEIHENYRING
|
| External Links |
|---|
| GenBank ID Protein
| AAB37487.1 |
| UniProtKB/Swiss-Prot ID
| P79251 |
| UniProtKB/Swiss-Prot Entry Name
| VATG1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| S82464 |
| GeneCard ID
| ATP6V1G1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
