| Identification |
|---|
| BMDB Protein ID
| BMDBP00773 |
| Secondary Accession Numbers
| None |
| Name
| V-type proton ATPase catalytic subunit A |
| Synonyms
|
Not Available
|
| Gene Name
| ATP6V1A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| Not Available |
| SNPs
| ATP6V1A |
| Gene Sequence
|
>1854 bp
ATGGATTTCTCCAAGCTCCCCAAAATACGTGATGAAGATAAAGAAAGCACGTTTGGTTAT
GTGCATGGGGTCTCAGGACCTGTGGTTACCGCCTGTGACATGGCAGGAGCAGCCATGTAC
GAGCTGGTGAGAGTGGGCCACAGCGAGTTGGTTGGAGAGATTATCCGATTAGAGGGCGAC
ATGGCTACTATCCAGGTGTATGAAGAAACTTCTGGTGTGTCTGTTGGAGACCCTGTACTT
CGCACTGGTAAACCCCTCTCAGTTGAGCTTTGTCCAGGCATTATGGGAGCCATTTTTGAT
GGTATTCAAAGACCTTTGTCGGATATCAGCAGTCAGACTCAAAGTATTTACATTCCCAGA
GGAGTAAATGTGTCTGCTCTTAGCAGAGATGTCAAATGGGATTTCACACCTTGCAAAAAC
CTACGGGTTGGTAGTCACATCACTGGTGGAGATATTTACGGAATTGTCAATGAGAACTCT
CTCATCAAACACAAAATCATGTTGCCTCCACGAAACAGAGGAACTGTCACCTACATCGCT
CCACCTGGAAATTACGATACCTCTGATGTCGTGTTGGAGCTTGAATTTGAAGGTATAAAG
GAGAAGTTCAGCATGGTCCAAGTATGGCCTGTACGTCAGGTTCGGCCTGTCACTGAGAAG
TTGCCAGCTAATCATCCTCTGTTGACTGGCCAGAGAGTCCTTGATGCCCTTTTTCCATGT
GTACAGGGAGGAACTACTGCAATCCCTGGGGCCTTTGGCTGTGGGAAGACAGTGATATCA
CAGTCTCTATCCAAGTATTCCAACAGTGATGTGATCATCTACGTAGGATGTGGTGAGAGA
GGAAACGAGATGTCTGAAGTCCTCCGGGACTTCCCAGAGCTCACGATGGAAGTCGATGGT
AAGGTAGAGTCAATTATGAAGAGAACAGCATTGGTAGCCAATACATCCAATATGCCTGTG
GCTGCTAGAGAAGCCTCTATTTATACTGGAATTACACTGTCAGAATATTTCCGTGACATG
GGCTATCATGTCAGTATGATGGCTGACTCCACCTCTCGATGGGCTGAGGCTCTTAGAGAA
ATCTCTGGTCGTTTGGCTGAAATGCCTGCAGATAGTGGATATCCTGCATATCTTGGTGCC
CGTTTGGCCTCTTTCTATGAGCGAGCCGGCAGAGTGAAGTGTCTTGGAAATCCTGAGAGG
GAAGGGAGTGTCAGCATTGTAGGAGCAGTTTCTCCACCTGGTGGTGACTTTTCTGATCCA
GTTACATCTGCTACTCTTGGTATTGTTCAGGTGTTCTGGGGCTTAGATAAGAAACTAGCT
CAACGTAAGCATTTCCCTTCTGTCAATTGGCTGATCAGCTACAGCAAGTACATGCGTGCC
TTGGATGAGTACTACGACAAACACTTCACAGAGTTCGTCCCTCTGAGGACCAAAGCTAAG
GAGATTCTGCAGGAAGAAGAAGACTTGGCAGAAATCGTACAGCTGGTGGGAAAGGCTTCT
CTAGCAGAAACAGATAAAATCACTCTGGAGGTAGCAAAACTTATCAAAGATGATTTCCTT
CAACAAAATGGATATACTCCTTATGACAGGTTCTGCCCATTCTACAAGACAGTGGGGATG
CTGTCCAACATGATTGCATTTTATGATATGGCCCGCAGAGCTGTTGAAACCACTGCCCAG
AGTGACAATAAAATCACATGGTCCATTATCCGTGAGCACATGGGGGAGATCCTCTATAAG
CTTTCCTCCATGAAATTCAAGGATCCAGTGAAAGATGGTGAGGCGAAGATCAAGGCCGAC
TATGCACAACTTCTTGAAGATATGCAGAATGCATTCCGTAGCCTTGAAGATTAG
|
| Protein Properties |
|---|
| Number of Residues
| 617 |
| Molecular Weight
| 68344.0 |
| Theoretical pI
| 5.25 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>V-type proton ATPase catalytic subunit A
MDFSKLPKIRDEDKESTFGYVHGVSGPVVTACDMAGAAMYELVRVGHSELVGEIIRLEGD
MATIQVYEETSGVSVGDPVLRTGKPLSVELGPGIMGAIFDGIQRPLSDISSQTQSIYIPR
GVNVSALSRDVKWDFTPCKNLRVGSHITGGDIYGIVNENSLIKHKIMLPPRNRGTVTYIA
PPGNYDTSDVVLELEFEGIKEKFSMVQVWPVRQVRPVTEKLPANHPLLTGQRVLDALFPC
VQGGTTAIPGAFGCGKTVISQSLSKYSNSDVIIYVGCGERGNEMSEVLRDFPELTMEVDG
KVESIMKRTALVANTSNMPVAAREASIYTGITLSEYFRDMGYHVSMMADSTSRWAEALRE
ISGRLAEMPADSGYPAYLGARLASFYERAGRVKCLGNPEREGSVSIVGAVSPPGGDFSDP
VTSATLGIVQVFWGLDKKLAQRKHFPSVNWLISYSKYMRALDEYYDKHFTEFVPLRTKAK
EILQEEEDLAEIVQLVGKASLAETDKITLEVAKLIKDDFLQQNGYTPYDRFCPFYKTVGM
LSNMIAFYDMARRAVETTAQSDNKITWSIIREHMGEILYKLSSMKFKDPVKDGEAKIKAD
YAQLLEDMQNAFRSLED
|
| External Links |
|---|
| GenBank ID Protein
| AAA30392.1 |
| UniProtKB/Swiss-Prot ID
| P31404 |
| UniProtKB/Swiss-Prot Entry Name
| VATA_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| M80430 |
| GeneCard ID
| ATP6V1A |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
