| Identification |
|---|
| BMDB Protein ID
| BMDBP00774 |
| Secondary Accession Numbers
| None |
| Name
| V-type proton ATPase subunit H |
| Synonyms
|
Not Available
|
| Gene Name
| ATP6V1H |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 14 |
| Locus
| Not Available |
| SNPs
| ATP6V1H |
| Gene Sequence
|
>1452 bp
ATGACCAAGATGGATATTCGGGGTGCTGTGGATGCTGCTGTTCCCACCAACATCATTGCC
GCCAAGGCTGCGGAAGTCCGTGCGAACAAAGTGAACTGGCAGTCCTACCTGCAGGGGCAG
ATGATTTCTTCTGAAGACTGCGAGTTCATTCAAAGATTTGAGATGAAAAGAAGTCCTGAG
GAGAAGCAGGAGATGCTTCAGACTGAAGGCAGTCAGCGTGCTAAGACATTTATAAATCTG
ATGACTCATATTTCCAAAGAGCAGACAGTTCAGTACATACTCACCCTGGTGGATGATACA
CTGCAGGAAAATCACCAGCGTGTTAGCATTTTCTTTGACTACGCTAAACGTAGCAAGAAC
ACTGCCTGGTCCTACTTCCTTCCGATGCTGAATCGCCAGGATCTCTTTACTGTTCATATG
ACAGCAAGAATTATTGCCAAGTTAGCAGCTTGGGGAAAAGAACTGATGGAAGGCAGCGAC
TTGAATTACTATTTCAATTGGATAAAGACTCAACTGAGTTCACAGAAACTGCGTGGTAGC
GGTGTCACTGCTGAAACAGGAACAGTCTCTTCAAGCGATAGTTCCCAGTATGTGCAGTGC
GTGGCCGGGTGTCTGCAGCTGATGCTCCGAGTCAATGAGTACCGCTTCGCCTGGGTGGAG
GCAGACGGGGTGAACTGCATCATGGGCGTTCTGAGTAACAAGTGTGGCTTTCAGCTCCAG
TATCAGATGATCTTTTCTGTGTGGCTCCTGGCTTTTAGCCCACAGATGTGTGAACACCTG
AGGCGCTACAACATCATCCCTGTCCTGTCTGACATCCTGCAGGAGTCGGTCAAAGAGAAG
GTGACGAGGATCATCCTCGCAGCATTCCGCAACTTCTTAGAAAAGTCAGTTGAACGAGAA
ACTCGCCAAGAGTATGCCCTGGCGATGATTCAGTGCAAAGTCCTGAAACAGCTGGAGAAT
TTGGAGCAGCAGAAGTACGACGACGAAGACATCAGTGAGGATATAAAGTTTCTCTTGGAG
AAGCTCGGTGAGAGTGTCCAGGATCTCAGCTCATTCGATGAATACAGTTCAGAACTTAAG
TCTGGAAGGTTGGAGTGGAGTCCTGTGCACAAATCTGAGAAATTTTGGAGAGAGAATCCT
GCGAGGTTAAATGAAAAGAATTATGAGCTCTTGAAAATTTTGACCAAACTTCTGGAGGTG
TCTGACGATCCCCAAGTCCTAGCTGTTGCCGCCCATGACGTTGGGGAGTATGTGCGCCAT
TACCCACGAGGCAAGCGGGTCATCGAACAGCTGGGTGGGAAGCAGCTGGTGATGAACCAC
ATGCACCACGAGGACCAGCAGGTGCGCTACAACGCCCTCCTGGCTGTACAGAAGCTCATG
GTGCACAACTGGGAATATCTTGGTAAACAACTCCAGTCTGAACAGCCGCAGACTGCAGCC
GCCCGGAGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 483 |
| Molecular Weight
| 55852.0 |
| Theoretical pI
| 6.59 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 6-31
- 67-86
- 98-117
- 137-158
- 164-184
- 196-222
|
| Protein Sequence
|
>V-type proton ATPase subunit H
MTKMDIRGAVDAAVPTNIIAAKAAEVRANKVNWQSYLQGQMISSEDCEFIQRFEMKRSPE
EKQEMLQTEGSQCAKTFINLMTHISKEQTVQYILTLVDDTLQENHQRVSIFFDYAKRSKN
TAWSYFLPMLNRQDLFTVHMAARIIAKLAAWGKELMEGSDLNYYFNWIKTQLSSQKLRGS
GVTAETGTVSSSDSSQYVQCVAGCLQLMLRVNEYRFAWVEADGVNCIMGVLSNKCGFQLQ
YQMIFSVWLLAFSPQMCEHLRRYNIIPVLSDILQESVKEKVTRIILAAFRNFLEKSVERE
TRQEYALAMIQCKVLKQLENLEQQKYDDEDISEDIKFLLEKLGESVQDLSSFDEYSSELK
SGRLEWSPVHKSEKFWRENAVRLNEKNYELLKILTKLLEVSDDPQVLAVAAHDVGEYVRH
YPRGKRVIEQLGGKQLVMNHMHHEDQQVRYNALLAVQKLMVHNWEYLGKQLQSEQPQTAA
ARS
|
| External Links |
|---|
| GenBank ID Protein
| AAC02987.1 |
| UniProtKB/Swiss-Prot ID
| O46563 |
| UniProtKB/Swiss-Prot Entry Name
| VATH_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF041338 |
| GeneCard ID
| ATP6V1H |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
