Showing Protein Sorbitol dehydrogenase (BMDBP00784)
| Identification | |||
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| BMDB Protein ID | BMDBP00784 | ||
| Secondary Accession Numbers |
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| Name | Sorbitol dehydrogenase | ||
| Synonyms | Not Available | ||
| Gene Name | SORD | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Amino acid transport and metabolism | ||
| Specific Function | Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is mostly active with xylitol, D-sorbitol (D-glucitol) and L-iditol as substrates, leading to the C2-oxidized products D-xylulose, D-fructose and L-sorbose, respectively (PubMed:9143345). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (By similarity). Cannot use NADP(+) as the electron acceptor. Has no activity on ethanol, methanol, glycerol, galactitol and fructose 6-phosphate (PubMed:9143345). | ||
| Pathways | Not Available | ||
| Reactions |
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| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 10 | ||
| Locus | Not Available | ||
| SNPs | SORD | ||
| Gene Sequence |
>1071 bp ATGGCGGCGGCCAAGCCCGAGAACCTCTCCCTGGTGGTGCACGGACCCGGAGACTTGCGC TTGGAAAACTATCCTATCCCTGAACCAGGCCCAAATGAGGTGCTTCTGAAGATGCATTCT GTTGGAATTTGTGGCTCAGATGTCCATTACTGGCAGCATGGTCGAATTGGAGATTTTGTT GTGAAAAAGCCAATGGTGCTGGGGCATGAAGCTTCAGGAACAGTCGTAAAAGTGGGATCA TTGGTCAGGCACCTACAACCAGGTGATCGTGTCGCCATCGAGCCTGGTGCTCCTCGAGAA ACTGATGAGTTCTGCAAGATTGGCCGATACAATCTGTCACCTACCATCTTCTTCTGCGCC ACGCCCCCTGATGATGGGAACCTCTGCCGGTTCTACAAGCACAATGCTAACTTCTGCTAC AAGCTTCCTGACAATGTCACCTTTGAGGAAGGGGCCCTGATTGAGCCACTGTCTGTGGGG ATCCATGCCTGCCGGCGAGCTGGAGTCACGCTGGGGAACAAGGTCCTTGTGTGTGGAGCT GGGCCAATTGGACTGGTCAGTTTGCTTGCAGCCAAGGCAATGGGTGCAGCTCAAGTGGTG GTGACTGATCTGTCAGCCTCTCGGTTGTCTAAAGCCAAGGAAGTCGGGGCTGATTTCATC CTCCAGATCTCCAACGAGAGCCCTCAGGAAATAGCCAAGAAAGTGGAAGGCCTGCTGGGC AGCAAGCCAGAAGTCACAATTGAGTGCACAGGGGTGGAGACCTCCATCCAAGCCGGCATC TACGCCACTCATTCTGGTGGGACCCTGGTGTTGGTGGGGCTGGGCTCTGAGATGACCAGC GTGCCCCTCGTGCACGCAGCCACCAGGGAGGTGGACATCAAGGGCGTGTTTCGATACTGC AATACATGGCCGATGGCGATTTCAATGCTTGCATCCAAGTCTGTGAATGTAAAGCCCTTG GTCACCCATCGGTTTCCTCTGGAGAAAGCTCTGGAGGCCTTTGAAACATCCAAAAAGGGT TTGGGGTTGAAAGTCATGATCAAGTGTGACCCCAACGACCAGAATCCATGA |
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| Protein Properties | |||
| Number of Residues | 356 | ||
| Molecular Weight | 38099.0 | ||
| Theoretical pI | 7.5 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
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| Transmembrane Regions | Not Available | ||
| Protein Sequence |
>Sorbitol dehydrogenase MAAAKPENLSLVVHGPGDLRLENYPIPEPGPNEVLLKMHSVGICGSDVHYWQHGRIGDFV VKKPMVLGHEASGTVVKVGSLVRHLQPGDRVAIEPGAPRETDEFCKIGRYNLSPTIFFCA TPPDDGNLCRFYKHNANFCYKLPDNVTFEEGALIEPLSVGIHACRRAGVTLGNKVLVCGA GPIGLVSLLAAKAMGAAQVVVTDLSASRLSKAKEVGADFILQISNESPQEIAKKVEGLLG SKPEVTIECTGVETSIQAGIYATHSGGTLVLVGLGSEMTSVPLVHAATREVDIKGVFRYC NTWPMAISMLASKSVNVKPLVTHRFPLEKALEAFETSKKGLGLKVMIKCDPNDQNP |
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| External Links | |||
| GenBank ID Protein | AAX46613.1 | ||
| UniProtKB/Swiss-Prot ID | Q58D31 | ||
| UniProtKB/Swiss-Prot Entry Name | DHSO_BOVIN | ||
| PDB IDs | |||
| GenBank Gene ID | BT021766 | ||
| GeneCard ID | SORD | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||