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Identification
BMDB Protein ID BMDBP00785
Secondary Accession Numbers
  • BMDBP03104
Name Pyruvate dehydrogenase protein X component
Synonyms Not Available
Gene Name PDHX
Protein Type Enzyme
Biological Properties
General Function Energy production and conversion
Specific Function Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex.
Pathways Not Available
Reactions
Pyruvic acid + Coenzyme A + NAD → Acetyl-CoA + Carbon dioxide + NADH details
S-Acetyldihydrolipoamide-E + Coenzyme A → Dihydrolipoamide + Acetyl-CoA details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 15
Locus Not Available
SNPs PDHX
Gene Sequence
>1506 bp
ATGGCGGCCTCCTGGAGGCTAGGCTGTGACCCGCGGCTGCTGCGTTGCCTTCTGGGCTTT
GGCAGTCGCAGAAGCCCAGAGCTGGTTAAGGGGGCTGCTAGGTGGTCTGTCGGCCGTGGA
GCTAGTTGGAGATGGTTTCACAGTACGCAGTGGCTGCGGGCTGATCCTATTAAGATACTA
ATGCCATCACTGTCTCCTACAATGGAAGAAGGGAACATTGTGAAATGGCTGAAAAAGGAG
GGTGAAGCTGTGAGTGCTGGAGATGCCTTATGTGAAATAGAGACTGACAAAGCTGTGGTT
ACCTTAGATGCGAGTGATGATGGCATCTTGGCCAAAATAGTGGTGGCAGAAGGATCTAAA
AATATACGGTTGGGTTCACTGATTGGTTTGCTAGTTGAAGAAGGAGAAGATTGGAAACAT
GTTGAAATTCCTAAAGATACGGGTCCTCCACCACCAGCTGCAAAACCATCAGTGCCTCCC
CCCTCAGCAGAACCACAGATTGCTACCCCTGTCAAGAAGGAACACCCACCAGGAAAAGTG
CAGTTCCGTTTAAGTCCAGCTGCCCGCAATATTCTGGAAAAGCACGCACTGGATGCTAAC
CAGGGCACAGCCACTGGCCCTCGGGGGATATTCACTAAAGAGGATGCTCTCAAACTGGTC
CAGTTGAAACAGACGGGCAAGATCACTGAACCCAGACCCACCGCAGCCCTGCCAACCACT
CCCGCAGCGCCTTTGCCCCCACAGGCTGCAGCCACAGCATCTTACCCCCGGCCGATGATC
CCTCCTGTATCCACTCCCGGACAACCTAATGTAGAGGGCACATTCACTGAAATCCCAGCT
AGCAATATTAGAAGAGTTATTGCCAAGAGATTAACTGAATCTAAAAGCACCATACCTCAT
GCGTATGCTACTACTGACTGTGACCTTGGAGCTGTCCTAACAGCTAGACAGAATCTGGTC
AGAGATGACATTAAAGTATCAGTAAACGATTTTATCATCAAGGCAGCAGCTGTTACACTT
AAACAAATGCCTAATGTTAATGCAAGCTGGGACGGAGAGGGTGCAAAGCAACTGCCCTCT
ATTGACATTTCAGTGGCAGTGGCAACAGATAGAGGTCTAATTACACCAGTCATAAAAGAT
GCTGCTGCTAAGGGTCTACAGGAGATTGCTGATTCTGTAAAGGCTCTATCAAAGAAAGCC
AGAGATGGAAAATTGTTACCTGAAGAATATCAAGGAGGATCTTTTAGTATTTCCAACTTG
GGGATGTTTGGCATCGATGAATTTACTGCCGTGATCAACCCTCCTCAGGCCTGCATTTTG
GCGGTAGGGAGATTCCGACCTGTGCTGAAGCTCACTCAGGATGAAGAGGGGAATGCCCAG
CTGCAGCAACGTCAGCTCATAACGGTCACCATGTCCAGTGACAGCCGGGTGGTAGACGAT
GAACTGGCCACCAGGTTTCTGGAAAGTTTTAAAGCAAACCTGGAGAATCCTCTCCGACTT
GCCTGA
Protein Properties
Number of Residues 501
Molecular Weight 53886.0
Theoretical pI 8.71
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions
  • 389-407
  • 410-426
  • 442-471
  • 536-555
  • 574-594
  • 640-659
  • 726-750
  • 772-810
Protein Sequence
>Pyruvate dehydrogenase protein X component
MAASWRLGCDPRLLRCLLGFGSRRSPELVKGAARWSVGRGASWRWFHSTQWLRADPIKIL
MPSLSPTMEEGNIVKWLKKEGEAVSAGDALCEIETDKAVVTLDASDDGILAKIVVAEGSK
NIRLGSLIGLLVEEGEDWKHVEIPKDTGPPPPAAKPSVPPPSAEPQIATPVKKEHPPGKV
QFRLSPAARNILEKHALDANQGTATGPRGIFTKEDALKLVQLKQTGKITEPRPTAALPTT
PAAPLPPQAAATASYPRPMIPPVSTPGQPNVEGTFTEIPASNIRRVIAKRLTESKSTIPH
AYATTDCDLGAVLTARQNLVRDDIKVSVNDFIIKAAAVTLKQMPNVNASWDGEGAKQLPS
IDISVAVATDRGLITPVIKDAAAKGLQEIADSVKALSKKARDGKLLPEEYQGGSFSISNL
GMFGIDEFTAVINPPQACILAVGRFRPVLKLTQDEEGNAQLQQRQLITVTMSSDSRVVDD
ELATRFLESFKANLENPLRLA
GenBank ID Protein AAI20414.1
UniProtKB/Swiss-Prot ID P22439
UniProtKB/Swiss-Prot Entry Name ODPX_BOVIN
PDB IDs Not Available
GenBank Gene ID BC120413
GeneCard ID PDHX
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available