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Identification |
BMDB Protein ID
| BMDBP00785 |
Secondary Accession Numbers
| |
Name
| Pyruvate dehydrogenase protein X component |
Synonyms
|
Not Available
|
Gene Name
| PDHX |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Energy production and conversion |
Specific Function
| Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex. |
Pathways
|
Not Available
|
Reactions
|
Pyruvic acid + Coenzyme A + NAD → Acetyl-CoA + Carbon dioxide + NADH |
details
|
S-Acetyldihydrolipoamide-E + Coenzyme A → Dihydrolipoamide + Acetyl-CoA |
details
|
|
GO Classification
|
Not Available
|
Cellular Location
|
Not Available
|
Gene Properties |
Chromosome Location
| 15 |
Locus
| Not Available |
SNPs
| PDHX |
Gene Sequence
|
>1506 bp
ATGGCGGCCTCCTGGAGGCTAGGCTGTGACCCGCGGCTGCTGCGTTGCCTTCTGGGCTTT
GGCAGTCGCAGAAGCCCAGAGCTGGTTAAGGGGGCTGCTAGGTGGTCTGTCGGCCGTGGA
GCTAGTTGGAGATGGTTTCACAGTACGCAGTGGCTGCGGGCTGATCCTATTAAGATACTA
ATGCCATCACTGTCTCCTACAATGGAAGAAGGGAACATTGTGAAATGGCTGAAAAAGGAG
GGTGAAGCTGTGAGTGCTGGAGATGCCTTATGTGAAATAGAGACTGACAAAGCTGTGGTT
ACCTTAGATGCGAGTGATGATGGCATCTTGGCCAAAATAGTGGTGGCAGAAGGATCTAAA
AATATACGGTTGGGTTCACTGATTGGTTTGCTAGTTGAAGAAGGAGAAGATTGGAAACAT
GTTGAAATTCCTAAAGATACGGGTCCTCCACCACCAGCTGCAAAACCATCAGTGCCTCCC
CCCTCAGCAGAACCACAGATTGCTACCCCTGTCAAGAAGGAACACCCACCAGGAAAAGTG
CAGTTCCGTTTAAGTCCAGCTGCCCGCAATATTCTGGAAAAGCACGCACTGGATGCTAAC
CAGGGCACAGCCACTGGCCCTCGGGGGATATTCACTAAAGAGGATGCTCTCAAACTGGTC
CAGTTGAAACAGACGGGCAAGATCACTGAACCCAGACCCACCGCAGCCCTGCCAACCACT
CCCGCAGCGCCTTTGCCCCCACAGGCTGCAGCCACAGCATCTTACCCCCGGCCGATGATC
CCTCCTGTATCCACTCCCGGACAACCTAATGTAGAGGGCACATTCACTGAAATCCCAGCT
AGCAATATTAGAAGAGTTATTGCCAAGAGATTAACTGAATCTAAAAGCACCATACCTCAT
GCGTATGCTACTACTGACTGTGACCTTGGAGCTGTCCTAACAGCTAGACAGAATCTGGTC
AGAGATGACATTAAAGTATCAGTAAACGATTTTATCATCAAGGCAGCAGCTGTTACACTT
AAACAAATGCCTAATGTTAATGCAAGCTGGGACGGAGAGGGTGCAAAGCAACTGCCCTCT
ATTGACATTTCAGTGGCAGTGGCAACAGATAGAGGTCTAATTACACCAGTCATAAAAGAT
GCTGCTGCTAAGGGTCTACAGGAGATTGCTGATTCTGTAAAGGCTCTATCAAAGAAAGCC
AGAGATGGAAAATTGTTACCTGAAGAATATCAAGGAGGATCTTTTAGTATTTCCAACTTG
GGGATGTTTGGCATCGATGAATTTACTGCCGTGATCAACCCTCCTCAGGCCTGCATTTTG
GCGGTAGGGAGATTCCGACCTGTGCTGAAGCTCACTCAGGATGAAGAGGGGAATGCCCAG
CTGCAGCAACGTCAGCTCATAACGGTCACCATGTCCAGTGACAGCCGGGTGGTAGACGAT
GAACTGGCCACCAGGTTTCTGGAAAGTTTTAAAGCAAACCTGGAGAATCCTCTCCGACTT
GCCTGA
|
Protein Properties |
Number of Residues
| 501 |
Molecular Weight
| 53886.0 |
Theoretical pI
| 8.71 |
Pfam Domain Function
|
Not Available |
Signals
|
|
Transmembrane Regions
|
- 389-407
- 410-426
- 442-471
- 536-555
- 574-594
- 640-659
- 726-750
- 772-810
|
Protein Sequence
|
>Pyruvate dehydrogenase protein X component
MAASWRLGCDPRLLRCLLGFGSRRSPELVKGAARWSVGRGASWRWFHSTQWLRADPIKIL
MPSLSPTMEEGNIVKWLKKEGEAVSAGDALCEIETDKAVVTLDASDDGILAKIVVAEGSK
NIRLGSLIGLLVEEGEDWKHVEIPKDTGPPPPAAKPSVPPPSAEPQIATPVKKEHPPGKV
QFRLSPAARNILEKHALDANQGTATGPRGIFTKEDALKLVQLKQTGKITEPRPTAALPTT
PAAPLPPQAAATASYPRPMIPPVSTPGQPNVEGTFTEIPASNIRRVIAKRLTESKSTIPH
AYATTDCDLGAVLTARQNLVRDDIKVSVNDFIIKAAAVTLKQMPNVNASWDGEGAKQLPS
IDISVAVATDRGLITPVIKDAAAKGLQEIADSVKALSKKARDGKLLPEEYQGGSFSISNL
GMFGIDEFTAVINPPQACILAVGRFRPVLKLTQDEEGNAQLQQRQLITVTMSSDSRVVDD
ELATRFLESFKANLENPLRLA
|
External Links |
GenBank ID Protein
| AAI20414.1 |
UniProtKB/Swiss-Prot ID
| P22439 |
UniProtKB/Swiss-Prot Entry Name
| ODPX_BOVIN |
PDB IDs
|
Not Available |
GenBank Gene ID
| BC120413 |
GeneCard ID
| PDHX |
GenAtlas ID
| Not Available |
HGNC ID
| Not Available |
References |
General References
| Not Available |