| Identification |
|---|
| BMDB Protein ID
| BMDBP00786 |
| Secondary Accession Numbers
| |
| Name
| Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| DBT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component. |
| Pathways
|
Not Available
|
| Reactions
|
| S-(3-Methylbutanoyl)-dihydrolipoamide-E + Coenzyme A → Isovaleryl-CoA + Dihydrolipoamide |
details
|
| S-(2-Methylpropionyl)-dihydrolipoamide-E + Coenzyme A → Isobutyryl-CoA + Dihydrolipoamide |
details
|
| 2-Ketobutyric acid + Coenzyme A + NAD → Propionyl-CoA + NADH |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| Not Available |
| SNPs
| DBT |
| Gene Sequence
|
>1449 bp
MOFXBAISITE.CCGCCGGAGATGGCTGCAGCGCTTGTGCTGAGGACCTGGAGCCGGGCT
GCGGGGCAGCTGATTTGTGTCCGCTACTTTCAAACATGTGGTAATGTTCATGTTTTGAAG
CCAAAATATGTGTGTTTCTTTGGTTATCCTCCATTCAAGTACAGTCATCCATATCAGTGG
CTAAAAACAACTGCTGCTCTCCAGGGACAGATTGTTCAGTTCAAACTCTCAGACATTGGA
GAAGGTATTAGAGAAGTAACTGTTAAAGAATGGTATGTAAAAGAAGGAGATACAGTGTCT
CAGTTTGATAGCATCTGTGAAGTTCAAAGTGATAAAGCTTCTGTTACTATCACTAGTCGT
TATGATGGAGTCATTAAAAAACTGTATTATAATCTAGATGATACTGCCTATGTGGGAAAG
CCATTAGTAGACATAGAAACGGAAGCTTTAAAAGATTCAGAAGAAGATGTTGTTGAAACC
CCTGCTGTGTCCCATGATGAACACACACACCAAGAGATAAAGGGCCAGAAAACACTGGCG
ACTCCTGCAGTTCGTCGCCTTGCAATGGAAAACAATATTAAGCTGAGTGAAGTTATTGGC
TCAGGAAAAGATGGCAGAATACTTAAAGAAGATATTCTCAACTATCTGGAAAAGCAAACA
GGAGCTATACTTCCTCCTTCACCAAAAGCTGAAATTATGCCACCTCCACCAAAACCAAAA
GACAGAACTATTCCTATTCCAATATCAAAGCCTCCAGTGTTCATAGGCAAAGACAGAACC
GAACCCGTGAAAGGCTTTCACAAAGCAATGGTCAAGACCATGTCTGCAGCGCTGAAGATA
CCTCATTTTGGGTATTGTGATGAGGTTGACCTTACTGAACTGGTTAAGCTACGAGAAGAA
TTAAAACCCATTGCTTTTGCTCGTGGAATTAAACTTTCCTTTATGCCCTTCTTCTTAAAA
GCTGCTTCCTTGGGATTACTACAGTTTCCTATTCTTAATGCTTCTGTGGATGAAAACTGC
CAGAACATAACATACAAGGCTTCTCATAACATTGGAATAGCGATGGATACAGAGCAGGGC
TTGATTGTACCTAATGTGAAAAATGTTCAGATCCGCTCCATATTTGAGATTGCCACTGAA
TTGAACCGCCTCCAGAAACTGGGCTCTGCGGGTCAGCTCAGCACTAATGACCTTATAGGA
GGAACGTTCACTCTTTCCAACATTGGATCAATCGGTGGTACCTATGCCAAACCAGTGATA
CTTCCACCTGAAGTGGCAATTGGGGCCCTGGGAACAATTAAGGCCCTTCCCCGATTTAAC
GAGAAAGGGGAAGTCTGTAAGGCCCAGATAATGAATGTGAGCTGGTCGGCTGATCACAGA
ATTATCGATGGCGCTACAGTGTCACGCTTCTCTAATTTGTGGAAATCCTACTTAGAAAAC
CCAGCTTTT
|
| Protein Properties |
|---|
| Number of Residues
| 482 |
| Molecular Weight
| 53410.0 |
| Theoretical pI
| 8.43 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
MAAALVLRTWSRAAGQLICVRYFQTCGNVHVLKPKYVCFFGYPPFKYSHPYQWLKTTAAL
QGQIVQFKLSDIGEGIREVTVKEWYVKEGDTVSQFDSICEVQSDKASVTITSRYDGVIKK
LYYNLDDTAYVGKPLVDIETEALKDSEEDVVETPAVSHDEHTHQEIKGQKTLATPAVRRL
AMENNIKLSEVIGSGKDGRILKEDILNYLEKQTGAILPPSPKAEIMPPPPKPKDRTIPIP
ISKPPVFIGKDRTEPVKGFHKAMVKTMSAALKIPHFGYCDEVDLTELVKLREELKPIAFA
RGIKLSFMPFFLKAASLGLLQFPILNASVDENCQNITYKASHNIGIAMDTEQGLIVPNVK
NVQIRSIFEIATELNRLQKLGSAGQLSTNDLIGGTFTLSNIGSIGGTYAKPVILPPEVAI
GALGTIKALPRFNEKGEVCKAQIMNVSWSADHRIIDGATVSRFSNLWKSYLENPAFMLLD
LK
|
| External Links |
|---|
| GenBank ID Protein
| AAA30597.1 |
| UniProtKB/Swiss-Prot ID
| P11181 |
| UniProtKB/Swiss-Prot Entry Name
| ODB2_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| M21572 |
| GeneCard ID
| DBT |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
