Showing Protein Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (BMDBP00786)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 11 metabolites
Identification
BMDB Protein ID BMDBP00786
Secondary Accession Numbers
  • BMDBP03113
Name Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
Synonyms Not Available
Gene Name DBT
Protein Type Enzyme
Biological Properties
General Function Energy production and conversion
Specific Function The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component.
Pathways Not Available
Reactions
S-(3-Methylbutanoyl)-dihydrolipoamide-E + Coenzyme A → Isovaleryl-CoA + Dihydrolipoamide details
S-(2-Methylpropionyl)-dihydrolipoamide-E + Coenzyme A → Isobutyryl-CoA + Dihydrolipoamide details
2-Ketobutyric acid + Coenzyme A + NAD → Propionyl-CoA + NADH details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 3
Locus Not Available
SNPs DBT
Gene Sequence 
>1449 bp
MOFXBAISITE.CCGCCGGAGATGGCTGCAGCGCTTGTGCTGAGGACCTGGAGCCGGGCT
GCGGGGCAGCTGATTTGTGTCCGCTACTTTCAAACATGTGGTAATGTTCATGTTTTGAAG
CCAAAATATGTGTGTTTCTTTGGTTATCCTCCATTCAAGTACAGTCATCCATATCAGTGG
CTAAAAACAACTGCTGCTCTCCAGGGACAGATTGTTCAGTTCAAACTCTCAGACATTGGA
GAAGGTATTAGAGAAGTAACTGTTAAAGAATGGTATGTAAAAGAAGGAGATACAGTGTCT
CAGTTTGATAGCATCTGTGAAGTTCAAAGTGATAAAGCTTCTGTTACTATCACTAGTCGT
TATGATGGAGTCATTAAAAAACTGTATTATAATCTAGATGATACTGCCTATGTGGGAAAG
CCATTAGTAGACATAGAAACGGAAGCTTTAAAAGATTCAGAAGAAGATGTTGTTGAAACC
CCTGCTGTGTCCCATGATGAACACACACACCAAGAGATAAAGGGCCAGAAAACACTGGCG
ACTCCTGCAGTTCGTCGCCTTGCAATGGAAAACAATATTAAGCTGAGTGAAGTTATTGGC
TCAGGAAAAGATGGCAGAATACTTAAAGAAGATATTCTCAACTATCTGGAAAAGCAAACA
GGAGCTATACTTCCTCCTTCACCAAAAGCTGAAATTATGCCACCTCCACCAAAACCAAAA
GACAGAACTATTCCTATTCCAATATCAAAGCCTCCAGTGTTCATAGGCAAAGACAGAACC
GAACCCGTGAAAGGCTTTCACAAAGCAATGGTCAAGACCATGTCTGCAGCGCTGAAGATA
CCTCATTTTGGGTATTGTGATGAGGTTGACCTTACTGAACTGGTTAAGCTACGAGAAGAA
TTAAAACCCATTGCTTTTGCTCGTGGAATTAAACTTTCCTTTATGCCCTTCTTCTTAAAA
GCTGCTTCCTTGGGATTACTACAGTTTCCTATTCTTAATGCTTCTGTGGATGAAAACTGC
CAGAACATAACATACAAGGCTTCTCATAACATTGGAATAGCGATGGATACAGAGCAGGGC
TTGATTGTACCTAATGTGAAAAATGTTCAGATCCGCTCCATATTTGAGATTGCCACTGAA
TTGAACCGCCTCCAGAAACTGGGCTCTGCGGGTCAGCTCAGCACTAATGACCTTATAGGA
GGAACGTTCACTCTTTCCAACATTGGATCAATCGGTGGTACCTATGCCAAACCAGTGATA
CTTCCACCTGAAGTGGCAATTGGGGCCCTGGGAACAATTAAGGCCCTTCCCCGATTTAAC
GAGAAAGGGGAAGTCTGTAAGGCCCAGATAATGAATGTGAGCTGGTCGGCTGATCACAGA
ATTATCGATGGCGCTACAGTGTCACGCTTCTCTAATTTGTGGAAATCCTACTTAGAAAAC
CCAGCTTTT
Protein Properties
Number of Residues 482
Molecular Weight 53410.0
Theoretical pI 8.43
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions Not Available
Protein Sequence 
>Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
MAAALVLRTWSRAAGQLICVRYFQTCGNVHVLKPKYVCFFGYPPFKYSHPYQWLKTTAAL
QGQIVQFKLSDIGEGIREVTVKEWYVKEGDTVSQFDSICEVQSDKASVTITSRYDGVIKK
LYYNLDDTAYVGKPLVDIETEALKDSEEDVVETPAVSHDEHTHQEIKGQKTLATPAVRRL
AMENNIKLSEVIGSGKDGRILKEDILNYLEKQTGAILPPSPKAEIMPPPPKPKDRTIPIP
ISKPPVFIGKDRTEPVKGFHKAMVKTMSAALKIPHFGYCDEVDLTELVKLREELKPIAFA
RGIKLSFMPFFLKAASLGLLQFPILNASVDENCQNITYKASHNIGIAMDTEQGLIVPNVK
NVQIRSIFEIATELNRLQKLGSAGQLSTNDLIGGTFTLSNIGSIGGTYAKPVILPPEVAI
GALGTIKALPRFNEKGEVCKAQIMNVSWSADHRIIDGATVSRFSNLWKSYLENPAFMLLD
LK
GenBank ID Protein AAA30597.1
UniProtKB/Swiss-Prot ID P11181
UniProtKB/Swiss-Prot Entry Name ODB2_BOVIN
PDB IDs
GenBank Gene ID M21572
GeneCard ID DBT
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available