Bovine Metabolome Database: Showing Protein Short-chain specific acyl-CoA dehydrogenase, mitochondrial (BMDBP00788)

Identification Biological properties Gene properties Protein properties External links References XML Show 7 metabolites

Identification

BMDB Protein ID

BMDBP00788

Secondary Accession Numbers

None

Name

Short-chain specific acyl-CoA dehydrogenase, mitochondrial

Synonyms

Not Available

Gene Name

ACADS

Protein Type

Enzyme

Biological Properties

General Function

Lipid transport and metabolism

Specific Function

Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains (PubMed:6712627).

Pathways

Butyrate Metabolism
Fatty Acid Metabolism
Lipid metabolism
Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids
Mitochondrial fatty acid beta-oxidation
Valine, Leucine, and Isoleucine Degradation

Reactions

2-Methylbutyryl-CoA + electron-transfer flavoprotein → Tiglyl-CoA + Reduced electron-transfer flavoprotein	details
Isobutyryl-CoA + electron-transfer flavoprotein → Methacrylyl-CoA + Reduced electron-transfer flavoprotein	details

GO Classification

Not Available

Cellular Location

Not Available

Gene Properties

Chromosome Location

Locus

Not Available

SNPs

ACADS

Gene Sequence

>1239 bp
ATGGCTGCCACGCTGCTCGCCCGGGCCTGTGGCCTTGTCCGCGGAGCCCCCTGGCCTTGG
GGCTGGCGTCGCCTACATACCGTCTACCAGTCTGTTGAACTGCCCGAGACTCACCAGATG
CTGCGGCAGACGTGCCGCGACTTTGCCGAGAAGGAGCTCTTTCCCATCGCAGCCCAGGTG
GACAAGGAGCATCGCTTCCCAGCAGCTCAGGTGAAGAAGATGGGCGAGCTGGGGCTTATG
GCCATGAATGTGCCCGAGGAGCTCAGCGGAGCCGGCCTTGATTACCTGGCCTACTCCATC
GCCATGGAGGAGATCAGCCGGGGCTGTGCCTCCACGGGAGTCATCATGAGTGTCAACAAT
TCCCTCTACTTAGGGCCCATCCTGAAGTTCGGCACCAAGGAGCAGAAGCAGCAGTGGGTT
GCTCCCTTCACTAGTGGTGACAAAATTGGCTGCTTTGCCCTCAGTGAACCAGGGAACGGC
AGCGACGCAGGGGCCGCGGCCACCACCGCGCGGGCAGACGGTGACTCGTGGGTCCTGAGT
GGCACCAAGGCCTGGATCACCAACGCCTGGGAGGCCTCGGCCGTAGTGGTCTTCGCCAGC
ACCGACAGATCCTTGCATAACAAGGGCATCAGTGCCTTCCTGGTCCCCATGCCCACACCC
GGCCTCACGCTGGGGAAGAAGGAAGACAAGCTGGGCATCCGGGCCTCGTCCACGGCCAAC
CTCATCTTCGAGGACCGTCGCATCCCCAAGGACAGCCTGCTGGGGGAGCCGGGGCTGGGC
TTCAAGATCGCCATGCAAACCCTGGACACGGGCCGCATCGGCATCGCCTCCCAGGCCCTG
GGCATTGCCCAGGCCGCCCTGGACTGTGCTGTGACCTACGCGGAGAACCGCAGTGCTTTC
GGGGCGCCCCTCACCAAGCTGCAGGCCATCCAGTTCAAGTTGGCGGACATGGCCCTCGCC
CTGGAGAGTGCCCGGCTGCTGACCTGGCGCGCTGCCATGCTGAAGGACAACAAAAAGCCT
TTCACCAAGGAGGCGGCAATGGCCAAGCTGGCTGCATCGGAGGCCGCAACTGCCATCACC
CACCAGGCCATGCAGATCCTGGGCGGCATGGGCTACGTGAAGGAGATGCCAGCCGAGCGG
CACTACCGCGACGCCCGCATCACCGAGATTTATGAAGGCACCAGTGAGATCCAGAGGCTC
GTGGTCGCCGGGCACCTGCTCAAGAGCTACCGGAGCTGA

Protein Properties

Number of Residues

412

Molecular Weight

44552.0

Theoretical pI

8.89

Pfam Domain Function

Not Available

Signals

None

Transmembrane Regions

Not Available

Protein Sequence

>Short-chain specific acyl-CoA dehydrogenase, mitochondrial
MAATLLARACGLVRGAPWPWGWRRLHTVYQSVELPETHQMLRQTCRDFAEKELFPIAAQV
DKEHRFPAAQVKKMGELGLMAMNVPEELSGAGLDYLAYSIAMEEISRGCASTGVIMSVNN
SLYLGPILKFGTKEQKQQWVAPFTSGDKIGCFALSEPGNGSDAGAAATTARADGDSWVLS
GTKAWITNAWEASAVVVFASTDRSLHNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTAN
LIFEDRRIPKDSLLGEPGLGFKIAMQTLDTGRIGIASQALGIAQAALDCAVTYAENRSAF
GAPLTKLQAIQFKLADMALALESARLLTWRAAMLKDNKKPFTKEAAMAKLAASEAATAIT
HQAMQILGGMGYVKEMPAERHYRDARITEIYEGTSEIQRLVVAGHLLKSYRS

External Links

GenBank ID Protein

AAI03366.1

UniProtKB/Swiss-Prot ID

Q3ZBF6

UniProtKB/Swiss-Prot Entry Name

ACADS_BOVIN

PDB IDs