| Identification |
|---|
| BMDB Protein ID
| BMDBP00799 |
| Secondary Accession Numbers
| None |
| Name
| Dipeptidyl peptidase 4 |
| Synonyms
|
Not Available
|
| Gene Name
| DPP4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| Not Available |
| SNPs
| DPP4 |
| Gene Sequence
|
>2298 bp
ATGAAGACACCATGGAAGGTGCTCCTGGGATTGCTGGCGATCGCTGCGCTCGTCACCGTC
ATCACTGTGCCCGTGGTTCTGCTGACCAAAGGCAATGATGCTTCAACTGATAGTCGCAGA
ACCTACACTCTAGCCGATTATTTAAAAAATACTTTTAGAATGAAATTCTACAACTTGAGA
TGGGTTTCAGATCATGAATATCTCTACAAACAAGAAAATAATATCTTGCTATTCAATGCT
GAATATGGAAACAGCTCCATTTTCTTGGAGAACAGTACATTTGATGAATTTGGACATTCT
ATAAATGATTATTCAGTTTCACCAGATAGACAATATATTCTCTTCGAATACAACTATGTG
AAGCAATGGAGGCATTCCTACACAGCTTCCTATGACATTTATGACTTAAATAAAAGGCAG
TTAATTACAGAAGAGAGAATCCCAAACAACACACAGTGGATCACATGGTCATCAGTGGGT
CATAAATTGGCATACGTTTGGAACAATGATATTTATGTGAAAAATGAACCAAATTCTCCA
AGTCAGAGGATCACATGGACTGGGAAAAAAGATGTAATCTATAATGGAATAACTGACTGG
GTTTATGAAGAGGAAGTCTTCAGTGCTTATTCCGCTCTGTGGTGGTCTCCAAACAGCACT
TTTTTAGCATATGCCCAATTTAACGACACAGAAGTCCCGCTGATTGAATACTCCTTCTAC
TCCGATGAGTCACTGCAATATCCAAAGACCGTGAAGATTCCATATCCAAAGGCAGGAGCT
GTGAATCCAACTATAAAGTTCTTTGTTGTAAATATCAGCAGTCTCAGCCCGAACATTAAT
GCAACTTCCCAACAAATTGTTCCTCCTGGTTCTGTGTTAATAGGGGACCACTACTTGTGT
GACGTGACATGGGTAACAGAAGAAAGGATTTCATTGCAGTGGCTCCGCAGGATTCAGAAC
TATTCGATCATGGATATCTGTGACTATGACAGGTCCACGGGAAGATGGATTTCCTCAGTG
GGACGGCAGCACATTGAAATAAGTACCACTGGCTGGGTTGGAAGATTTAGGCCTGCAGAG
CCTCATTTTACCTCTGACGGGAATAGCTTCTACAAGATCATTAGCAACGAAGAGGGTTAC
AAACACATTTGTCACTTCCAAACAGATAAGAGAAATTGCACATTTATTACAAAAGGAGCC
TGGGAGGTCATTGGGATAGAAGCTCTTACCAGTGATTATCTATACTACATTAGCAATGAA
TATAAAGGAATGCCAGGTGCAAGAAATCTTTATAAAATCCAACTTAATGACTACACAAAA
GTGACGTGCCTCAGCTGTGAGCTGAATCCAGACAGGTGTCAGTATTACTCTGTATCGTTC
AGTCAAGAGGCAAAGTACTATCAGCTGAGATGTTCCGGTCCCGGTCTGCCCCTCTATACT
CTGCATAACAGCAACAATGATAAAGAACTGAGAGTCCTGGAAAACAATTCAGATTTGGAT
CAAGTGCTGCAGGATGTCCAGATGCCCTCAAAGAAACTGGACTTCATTCATTTGCATGGG
ACAAAATTTTGGTATCAGATGATCTTGCCTCCTCATTTTGATAAATCCAAGAAATATCCT
CTGCTATTAGAAGTATATGCAGGCCCCTGTAGTCAAAAAGCGGATGCTATCTTCAGACTC
AACTGGGCTACTTACCTTGCAAGCACAGAAAACATTATAGTAGCTAGCTTTGATGGCAGA
GGAAGTGGTTACCAAGGAGATAAGATCATGCACGCAATCAACAGAAGATTGGGAACATTT
GAAGTTGAAGATCAAATTGAAGCAACCAGACAGTTTTCAAAAATGGGATTTGTGGACGAC
AAACGGATTGCAATTTGGGGCTGGTCATACGGAGGGTACGTAACCTCAATGGTGCTGGGA
GCAGGAAGTGGTGTGTTCAAGTGTGGAATAGCCGTGGCGCCTGTATCCAAGTGGGAGTAC
TATGACTCCGTGTACACAGAACGTTACATGGGTCTTCCAACTCCAGAAGACAACCTTGAC
TCTTACAGGAATTCAACAGTCATGAGCAGAGCTGAAAATTTTAAACAAGTTGAGTACCTC
CTTATTCATGGAACAGCAGATGATAACGTTCACTTTCAGCAGTCAGCTCAGATCTCCAAA
GCCCTGGTGGATGCTGGAGTGGATTTCCAGTCAATGTGGTATACAGATGAAGACCACGGG
ATCGCCAGCAGCACAGCACACCAACACATATACACCCACATGAGCCACTTCCTAAAACAA
TGCTTCTCTCTACTTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 765 |
| Molecular Weight
| 88369.0 |
| Theoretical pI
| 6.32 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Dipeptidyl peptidase 4
MKTPWKVLLGLLAIAALVTVITVPVVLLTKGNDASTDSRRTYTLADYLKNTFRMKFYNLR
WVSDHEYLYKQENNILLFNAEYGNSSIFLENSTFDEFGHSINDYSVSPDRQYILFEYNYV
KQWRHSYTASYDIYDLNKRQLITEERIPNNTQWITWSSVGHKLAYVWNNDIYVKNEPNSP
SQRITWTGKKDVIYNGITDWVYEEEVFSAYSALWWSPNSTFLAYAQFNDTEVPLIEYSFY
SDESLQYPKTVKIPYPKAGAVNPTIKFFVVNISSLSPNINATSQQIVPPGSVLIGDHYLC
DVTWVTEERISLQWLRRIQNYSIMDICDYDRSTGRWISSVGRQHIEISTTGWVGRFRPAE
PHFTSDGNSFYKIISNEEGYKHICHFQTDKRNCTFITKGAWEVIGIEALTSDYLYYISNE
YKGMPGARNLYKIQLNDYTKVTCLSCELNPDRCQYYSVSFSQEAKYYQLRCSGPGLPLYT
LHNSNNDKELRVLENNSDLDQVLQDVQMPSKKLDFIHLHGTKFWYQMILPPHFDKSKKYP
LLLEVYAGPCSQKADAIFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTF
EVEDQIEATRQFSKMGFVDDKRIAIWGWSYGGYVTSMVLGAGSGVFKCGIAVAPVSKWEY
YDSVYTERYMGLPTPEDNLDSYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISK
ALVDAGVDFQSMWYTDEDHGIASSTAHQHIYTHMSHFLKQCFSLL
|
| External Links |
|---|
| GenBank ID Protein
| AAL67836.1 |
| UniProtKB/Swiss-Prot ID
| P81425 |
| UniProtKB/Swiss-Prot Entry Name
| DPP4_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| AF461806 |
| GeneCard ID
| DPP4 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
