Showing Protein Dipeptidyl peptidase 4 (BMDBP00799)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00799 |
| Secondary Accession Numbers | None |
| Name | Dipeptidyl peptidase 4 |
| Synonyms | Not Available |
| Gene Name | DPP4 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Amino acid transport and metabolism |
| Specific Function | Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 2 |
| Locus | Not Available |
| SNPs | DPP4 |
| Gene Sequence |
>2298 bp ATGAAGACACCATGGAAGGTGCTCCTGGGATTGCTGGCGATCGCTGCGCTCGTCACCGTC ATCACTGTGCCCGTGGTTCTGCTGACCAAAGGCAATGATGCTTCAACTGATAGTCGCAGA ACCTACACTCTAGCCGATTATTTAAAAAATACTTTTAGAATGAAATTCTACAACTTGAGA TGGGTTTCAGATCATGAATATCTCTACAAACAAGAAAATAATATCTTGCTATTCAATGCT GAATATGGAAACAGCTCCATTTTCTTGGAGAACAGTACATTTGATGAATTTGGACATTCT ATAAATGATTATTCAGTTTCACCAGATAGACAATATATTCTCTTCGAATACAACTATGTG AAGCAATGGAGGCATTCCTACACAGCTTCCTATGACATTTATGACTTAAATAAAAGGCAG TTAATTACAGAAGAGAGAATCCCAAACAACACACAGTGGATCACATGGTCATCAGTGGGT CATAAATTGGCATACGTTTGGAACAATGATATTTATGTGAAAAATGAACCAAATTCTCCA AGTCAGAGGATCACATGGACTGGGAAAAAAGATGTAATCTATAATGGAATAACTGACTGG GTTTATGAAGAGGAAGTCTTCAGTGCTTATTCCGCTCTGTGGTGGTCTCCAAACAGCACT TTTTTAGCATATGCCCAATTTAACGACACAGAAGTCCCGCTGATTGAATACTCCTTCTAC TCCGATGAGTCACTGCAATATCCAAAGACCGTGAAGATTCCATATCCAAAGGCAGGAGCT GTGAATCCAACTATAAAGTTCTTTGTTGTAAATATCAGCAGTCTCAGCCCGAACATTAAT GCAACTTCCCAACAAATTGTTCCTCCTGGTTCTGTGTTAATAGGGGACCACTACTTGTGT GACGTGACATGGGTAACAGAAGAAAGGATTTCATTGCAGTGGCTCCGCAGGATTCAGAAC TATTCGATCATGGATATCTGTGACTATGACAGGTCCACGGGAAGATGGATTTCCTCAGTG GGACGGCAGCACATTGAAATAAGTACCACTGGCTGGGTTGGAAGATTTAGGCCTGCAGAG CCTCATTTTACCTCTGACGGGAATAGCTTCTACAAGATCATTAGCAACGAAGAGGGTTAC AAACACATTTGTCACTTCCAAACAGATAAGAGAAATTGCACATTTATTACAAAAGGAGCC TGGGAGGTCATTGGGATAGAAGCTCTTACCAGTGATTATCTATACTACATTAGCAATGAA TATAAAGGAATGCCAGGTGCAAGAAATCTTTATAAAATCCAACTTAATGACTACACAAAA GTGACGTGCCTCAGCTGTGAGCTGAATCCAGACAGGTGTCAGTATTACTCTGTATCGTTC AGTCAAGAGGCAAAGTACTATCAGCTGAGATGTTCCGGTCCCGGTCTGCCCCTCTATACT CTGCATAACAGCAACAATGATAAAGAACTGAGAGTCCTGGAAAACAATTCAGATTTGGAT CAAGTGCTGCAGGATGTCCAGATGCCCTCAAAGAAACTGGACTTCATTCATTTGCATGGG ACAAAATTTTGGTATCAGATGATCTTGCCTCCTCATTTTGATAAATCCAAGAAATATCCT CTGCTATTAGAAGTATATGCAGGCCCCTGTAGTCAAAAAGCGGATGCTATCTTCAGACTC AACTGGGCTACTTACCTTGCAAGCACAGAAAACATTATAGTAGCTAGCTTTGATGGCAGA GGAAGTGGTTACCAAGGAGATAAGATCATGCACGCAATCAACAGAAGATTGGGAACATTT GAAGTTGAAGATCAAATTGAAGCAACCAGACAGTTTTCAAAAATGGGATTTGTGGACGAC AAACGGATTGCAATTTGGGGCTGGTCATACGGAGGGTACGTAACCTCAATGGTGCTGGGA GCAGGAAGTGGTGTGTTCAAGTGTGGAATAGCCGTGGCGCCTGTATCCAAGTGGGAGTAC TATGACTCCGTGTACACAGAACGTTACATGGGTCTTCCAACTCCAGAAGACAACCTTGAC TCTTACAGGAATTCAACAGTCATGAGCAGAGCTGAAAATTTTAAACAAGTTGAGTACCTC CTTATTCATGGAACAGCAGATGATAACGTTCACTTTCAGCAGTCAGCTCAGATCTCCAAA GCCCTGGTGGATGCTGGAGTGGATTTCCAGTCAATGTGGTATACAGATGAAGACCACGGG ATCGCCAGCAGCACAGCACACCAACACATATACACCCACATGAGCCACTTCCTAAAACAA TGCTTCTCTCTACTTTAG |
| Protein Properties | |
| Number of Residues | 765 |
| Molecular Weight | 88369.0 |
| Theoretical pI | 6.32 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions |
|
| Protein Sequence |
>Dipeptidyl peptidase 4 MKTPWKVLLGLLAIAALVTVITVPVVLLTKGNDASTDSRRTYTLADYLKNTFRMKFYNLR WVSDHEYLYKQENNILLFNAEYGNSSIFLENSTFDEFGHSINDYSVSPDRQYILFEYNYV KQWRHSYTASYDIYDLNKRQLITEERIPNNTQWITWSSVGHKLAYVWNNDIYVKNEPNSP SQRITWTGKKDVIYNGITDWVYEEEVFSAYSALWWSPNSTFLAYAQFNDTEVPLIEYSFY SDESLQYPKTVKIPYPKAGAVNPTIKFFVVNISSLSPNINATSQQIVPPGSVLIGDHYLC DVTWVTEERISLQWLRRIQNYSIMDICDYDRSTGRWISSVGRQHIEISTTGWVGRFRPAE PHFTSDGNSFYKIISNEEGYKHICHFQTDKRNCTFITKGAWEVIGIEALTSDYLYYISNE YKGMPGARNLYKIQLNDYTKVTCLSCELNPDRCQYYSVSFSQEAKYYQLRCSGPGLPLYT LHNSNNDKELRVLENNSDLDQVLQDVQMPSKKLDFIHLHGTKFWYQMILPPHFDKSKKYP LLLEVYAGPCSQKADAIFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTF EVEDQIEATRQFSKMGFVDDKRIAIWGWSYGGYVTSMVLGAGSGVFKCGIAVAPVSKWEY YDSVYTERYMGLPTPEDNLDSYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISK ALVDAGVDFQSMWYTDEDHGIASSTAHQHIYTHMSHFLKQCFSLL |
| External Links | |
| GenBank ID Protein | AAL67836.1 |
| UniProtKB/Swiss-Prot ID | P81425 |
| UniProtKB/Swiss-Prot Entry Name | DPP4_BOVIN |
| PDB IDs | |
| GenBank Gene ID | AF461806 |
| GeneCard ID | DPP4 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |