Identification
BMDB Protein ID BMDBP00804
Secondary Accession Numbers
  • BMDBP03107
Name Lanosterol synthase
Synonyms Not Available
Gene Name LSS
Protein Type Enzyme
Biological Properties
General Function Translation, ribosomal structure and biogenesis
Specific Function Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency.
Pathways
  • Lanosterol biosynthesis
  • Lanosterol from farnesyl diphosphate: step 3/3
  • Terpene metabolism
Reactions Not Available
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 1
Locus Not Available
SNPs LSS
Gene Sequence Not Available
Protein Properties
Number of Residues 732
Molecular Weight 83184.0
Theoretical pI 6.82
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions
  • 24-Jun
Protein Sequence
>Lanosterol synthase
MTEGTCLRRRGGPYKTEPATDLSRWRLSNQVGRQTWTYSQEEDPVREQSGLEAHLLGLDT
KSFFKDLPKAHTACRGALNGVTFYAALQTEDGHWAGDYGGPLFLLPGLLITCHVANIPLP
AGYREEIIRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGPDDPDLVRARNLL
HKKGGAVFIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWMPAHPSTIWCHCRQVYLPM
AYCYSTRLSAEEGPLVQSLRQELYLEDYSCIDWAAHRNSVAPDDLYTPHSWLLHVVYAIL
NLYERHHSTSLRQWATQKLYEHIAADDRFTKCISIGPISKTINMLVRWHVDGPASAVFQE
HVSRIPDYLWLGLDGMKMQGTNGSQIWDTAFAIQALLEARAQHRPEFWSCLRKAHEYLRI
SQVPDNFPDYQKYYRHMSKGGFSFSTLDCGWIVADCTAEALKSILLLQEKCPFVSNHVPR
ERLFDTVAVLLSLRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQA
LKTFHKQFPDHRAGEIRETLEQGLQFCRQKQRPDGSWEGSWGVCFTYGAWFGLEAFACMG
HTYHNGVACAEISRACDFLLSRQMADGGWGEDFESCKQRRYVQSAQSQIHNTCWALMGLM
AVRHPDVAALERGVSYLLEKQLPNGDWPQENISGVFNKSCAISYTSYRNVFPIWTLGRFS
RLHPDPALAGHP
GenBank ID Protein ABD24094.1
UniProtKB/Swiss-Prot ID P84466
UniProtKB/Swiss-Prot Entry Name ERG7_BOVIN
PDB IDs Not Available
GenBank Gene ID DQ372933
GeneCard ID LSS
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available