Showing Protein Matrix metalloproteinase-14 (BMDBP00814)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00814 |
| Secondary Accession Numbers | None |
| Name | Matrix metalloproteinase-14 |
| Synonyms | Not Available |
| Gene Name | MMP14 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in calcium ion binding |
| Specific Function | Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis. |
| Pathways |
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| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 10 |
| Locus | Not Available |
| SNPs | MMP14 |
| Gene Sequence | Not Available |
| Protein Properties | |
| Number of Residues | 582 |
| Molecular Weight | 65883.0 |
| Theoretical pI | 8.12 |
| Pfam Domain Function | Not Available |
| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>Matrix metalloproteinase-14 MSPAPRPACSLLLPVLTLASALASLSSAQSSFSPEAWLQQHGYLPPGDLRTHTQRSPQSL SAAIAAMQRFYGLRVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQH NEITFCIQNYTPNVGEYATFEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFF AEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHEL GHALGLEHSNDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGSKSGSPTKMPPQPRTTS RPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRKNQVMDGYPMPIGQFW RGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDRIDAALFW MPNGKTYFFRGNKYYRFNEELRIVESEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGN KYWKFNNQKLKVEPGYPKSALRDWMGCPSSGGQPDEGTEEETEVIIIEVDEEGSGAVSAA AVVLPVLLLLLVLAVGLAVFFFRRHGTPKRLLYCQRSLLDKV |
| External Links | |
| GenBank ID Protein | AAG28170.1 |
| UniProtKB/Swiss-Prot ID | Q9GLE4 |
| UniProtKB/Swiss-Prot Entry Name | MMP14_BOVIN |
| PDB IDs | |
| GenBank Gene ID | AF290429 |
| GeneCard ID | MMP14 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |