| Identification |
|---|
| BMDB Protein ID
| BMDBP00815 |
| Secondary Accession Numbers
| None |
| Name
| Collagenase 3 |
| Synonyms
|
Not Available
|
| Gene Name
| MMP13 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 15 |
| Locus
| Not Available |
| SNPs
| MMP13 |
| Gene Sequence
|
>1416 bp
ATGCACCCAAGGGTCCTGGCTGGCTTCCTCTTCTTCAGCTGGACGGCTTGTTGGTCTCTG
CCCCTTCCCAGTGATGGAGATTCTGAAGACTTGTCCGAGGAAGACTTCCAGTTTGCAGAG
AGCTACCTGAAATCATACTACTATCCTCAGAATCCTGCTGGAATCCTGAAGAAAACTGCA
GCAAGCTCTGTGATTGACAGGCTTAGAGAAATGCAGTCATTTTTTGGCTTAGAGGTGACT
GGCAGACTTGATGATAACACCTTAGACATCATGAAAAAACCAAGATGTGGGGTCCCTGAT
GTGGGTGAATACAATGTTTTTCCTCGAACTCTCAAGTGGTCCAAAATGAACTTAACCTAC
AGAATTGTGAATTATACACCTGATCTGACTCATTCTGAAGTGGAAAAGGCCTTCAGAAAA
GCCTTCAAGGTGTGGTCTGATGTGACCCCTCTGAATTTTACCAGAATTCACAATGGCACT
GCTGATATCATGATCTCTTTTGGAACTAAAGAGCATGGTGACTTCTACCCATTTGATGGA
CCCTCTGGTCTGTTGGCTCACGCTTTCCCTCCTGGACCAAATTATGGAGGAGATGCTCAT
TTTGATGATGATGAAACCTGGACAAGTAGTTCCAAAGGCTACAACTTGTTTCTTGTTGCT
GCCCATGAGTTTGGCCATTCCTTAGGATTGGACCACTCCAAGGACCCAGGAGCACTCATG
TTTCCCATCTACACCTACACTGGCAAAAGCCACTTTATGCTTCCTGATGATGATGTCCAA
GGGATTCAGTCTCTCTATGGTCCAGGAGATGAAGACCCCTACTCTAAACATCCCAAAACG
CCAGACAAATGTGACCCTTCCTTATCCCTTGATGCCATAACCAGTCTCCGCGGAGAAACA
CTGATCTTTAAAGACAGATTCTTCTGGCGGCTGCATCCTCAGCAGGTTGAAGCAGAGCTG
TTTTTAACAAAATCGTTTGGGCCAGAACTTCCCAACCGTATTGATGCCGCCTATGAGCAC
CCTTCCCATGACCTTATCTTCATCTTTAGAGGCAGAAAATTTTGGGCACTTAGTGGTTAT
GATATTCTGGAAGATTACCCAAAAAAAATATCTGAACTGGGATTTCCAAAACACGTTAAA
AAGATCAGCGCAGCCCTTCACTTTGAGGATTCAGGGAAGACGCTCTTCTTTTCAGAAAAC
CAAGTCTGGAGCTATGATGACACTAACCATGTGATGGATAAAGACTACCCGAGACTCATT
GAAGAGGTCTTCCCAGGAATTGGTGATAAAGTAGATGCTGTCTACCAGAAAAATGGTTAT
ATCTATTTTTTCAATGGACCCATACAGTTTGAATACAGCATCTGGAGTAACCGTATTGTT
CGAGTCATGACAACAAATTCCTTATTGTGGTGTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 471 |
| Molecular Weight
| 53921.0 |
| Theoretical pI
| 5.42 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 6-31
- 67-86
- 98-117
- 137-158
- 164-184
- 196-222
|
| Protein Sequence
|
>Collagenase 3
MHPRVLAGFLFFSWTACWSLPLPSDGDSEDLSEEDFQFAESYLKSYYYPQNPAGILKKTA
ASSVIDRLREMQSFFGLEVTGRLDDNTLDIMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY
RIVNYTPDLTHSEVEKAFRKAFKVWSDVTPLNFTRIHNGTADIMISFGTKEHGDFYPFDG
PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM
FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPYSKHPKTPDKCDPSLSLDAITSLRGET
LIFKDRFFWRLHPQQVEAELFLTKSFGPELPNRIDAAYEHPSHDLIFIFRGRKFWALSGY
DILEDYPKKISELGFPKHVKKISAALHFEDSGKTLFFSENQVWSYDDTNHVMDKDYPRLI
EEVFPGIGDKVDAVYQKNGYIYFFNGPIQFEYSIWSNRIVRVMTTNSLLWC
|
| External Links |
|---|
| GenBank ID Protein
| AAC24596.1 |
| UniProtKB/Swiss-Prot ID
| O77656 |
| UniProtKB/Swiss-Prot Entry Name
| MMP13_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF072685 |
| GeneCard ID
| MMP13 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
