| Identification |
|---|
| BMDB Protein ID
| BMDBP00818 |
| Secondary Accession Numbers
| None |
| Name
| Cystathionine gamma-lyase |
| Synonyms
|
Not Available
|
| Gene Name
| CTH |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function (By similarity). |
| Pathways
|
- Amino-acid biosynthesis
- Cysteine Metabolism
- Glycine and Serine Metabolism
- Homocysteine Degradation
- L-cysteine biosynthesis
- L-cysteine from L-homocysteine and L-serine: step 2/2
- Methionine Metabolism
- Selenoamino Acid Metabolism
|
| Reactions
|
| Selenocystathionine + Water → Selenocysteine + Ammonia + 2-Ketobutyric acid |
details
|
| L-Cysteine + Water → Hydrogen sulfide + Pyruvic acid + Ammonia |
details
|
| L-Cystathionine + Water → L-Cysteine + 2-Ketobutyric acid + Ammonia |
details
|
| L-Cystathionine + Water → L-Cysteine + 2-Ketobutyric acid |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| CTH |
| Gene Sequence
|
>1218 bp
ATGCAGGAAAAAGAAGCCTCCCCACACGGATTCCTGCCTAGGTTCCAGCATTTCGCTACG
CAGGCCATCCACGTGGGCCAAGAACCGGAGCAATGGACCTCCCAAGCTGTAGTGCCCCCT
ATCTCGCTGTCCACCACGTTCAAGCAAGGGGCTCCTGGCCAGCACTCGGGTTTTGAGTAT
AGCCGTTCTGGAAATCCCACCCGGAATTGCTTGGAAAAAGCAGTGGCGGCGCTGGATGGG
GCTAAGTACAGTTTGGCCTTTGCTTCAGGTTTAGCAGCCACTGTGACCATTACCCATCTC
TTAAAAGCAGGAGACCAGATTATTTGTATGGATGATGTGTATGGAGGTACAAACAGGTAC
TTCAGGCAGGTGGCAACTGAATTTGGATTAAAGATTTCTTTTGTTGATTGTTCCAAACCC
AAATTGCTAGAGGCAGCTATTACACCAGAAACCAAGCTTGTTTGGATTGAAACCCCCACA
AACCCTAGCTTGAAGATGATTGACATTGAAGCCTGCGCACATACGGTCCATAAACATGGA
GACATCATTTTGGTTGTGGATAACACTTTTATGTCAGCATATTTCCAGCGGCCTTTGTCT
CTGGGAGCTGATATTTGTATGTATTCAGCAACAAAATACATGAATGGCTACAGTGATGTT
GTAATGGGCTTAGTGTCACTGAATTCTGAGAGCCTTCATGATAGGCTCCGTTTCTTGCAA
AATTCTCTTGGAGCAGTTCCATCTCCTATTGACTGTTACCTCTGCAATCGGGGTCTGAAG
ACTCTACAAGTCCGCATGGAGAAGCATTTCGAAAACGGAATGGCAGTTGCTCAGTTTTTG
GAGTCGAATCCTCAGGTGGAAAAGGTTATTTATCCTGGGCTGCCTTCTCATCCTCAGCAT
GAGCTGGCCAAGCGTCAGTGCACAGGTTGCCCGGGGATGGTCACCTTTTATATCAAGGGC
TCTCTTCAACATGCTGAAACTTTCCTCCAGAACTTAAAGTTATTTACTCTGGCTGAAAGC
TTGGGAGGATACGAAAGTCTTGCTGAGCTTCCGGCAATCATGACCCATGCATCAGTGCCT
AAGAGTGACAGAGAAGTCCTTGGAATTAGTGACACACTTATTCGACTCTCAGTGGGCTTA
GAGGATAAACAAGACCTACTGGATGATCTAGATCAAGCTTTGAAGGCAGCTAACCCTCCA
AATGCAAGTTCCAACTAG
|
| Protein Properties |
|---|
| Number of Residues
| 405 |
| Molecular Weight
| 44406.0 |
| Theoretical pI
| 6.39 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Cystathionine gamma-lyase
MQEKEASPHGFLPRFQHFATQAIHVGQEPEQWTSQAVVPPISLSTTFKQGAPGQHSGFEY
SRSGNPTRNCLEKAVAALDGAKYSLAFASGLAATVTITHLLKAGDQIICMDDVYGGTNRY
FRQVATEFGLKISFVDCSKPKLLEAAITPETKLVWIETPTNPSLKMIDIEACAHTVHKHG
DIILVVDNTFMSAYFQRPLSLGADICMYSATKYMNGYSDVVMGLVSLNSESLHDRLRFLQ
NSLGAVPSPIDCYLCNRGLKTLQVRMEKHFENGMAVAQFLESNPQVEKVIYPGLPSHPQH
ELAKRQCTGCPGMVTFYIKGSLQHAETFLQNLKLFTLAESLGGYESLAELPAIMTHASVP
KSDREVLGISDTLIRLSVGLEDKQDLLDDLDQALKAANPPNASSN
|
| External Links |
|---|
| GenBank ID Protein
| AAX46332.1 |
| UniProtKB/Swiss-Prot ID
| Q58DW2 |
| UniProtKB/Swiss-Prot Entry Name
| CGL_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT021485 |
| GeneCard ID
| CTH |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
