Showing Protein Cystathionine gamma-lyase (BMDBP00818)
| Identification | |||||||||
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| BMDB Protein ID | BMDBP00818 | ||||||||
| Secondary Accession Numbers | None | ||||||||
| Name | Cystathionine gamma-lyase | ||||||||
| Synonyms | Not Available | ||||||||
| Gene Name | CTH | ||||||||
| Protein Type | Enzyme | ||||||||
| Biological Properties | |||||||||
| General Function | Amino acid transport and metabolism | ||||||||
| Specific Function | Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function (By similarity). | ||||||||
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| Reactions |
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| GO Classification | Not Available | ||||||||
| Cellular Location | Not Available | ||||||||
| Gene Properties | |||||||||
| Chromosome Location | 7 | ||||||||
| Locus | Not Available | ||||||||
| SNPs | CTH | ||||||||
| Gene Sequence |
>1218 bp ATGCAGGAAAAAGAAGCCTCCCCACACGGATTCCTGCCTAGGTTCCAGCATTTCGCTACG CAGGCCATCCACGTGGGCCAAGAACCGGAGCAATGGACCTCCCAAGCTGTAGTGCCCCCT ATCTCGCTGTCCACCACGTTCAAGCAAGGGGCTCCTGGCCAGCACTCGGGTTTTGAGTAT AGCCGTTCTGGAAATCCCACCCGGAATTGCTTGGAAAAAGCAGTGGCGGCGCTGGATGGG GCTAAGTACAGTTTGGCCTTTGCTTCAGGTTTAGCAGCCACTGTGACCATTACCCATCTC TTAAAAGCAGGAGACCAGATTATTTGTATGGATGATGTGTATGGAGGTACAAACAGGTAC TTCAGGCAGGTGGCAACTGAATTTGGATTAAAGATTTCTTTTGTTGATTGTTCCAAACCC AAATTGCTAGAGGCAGCTATTACACCAGAAACCAAGCTTGTTTGGATTGAAACCCCCACA AACCCTAGCTTGAAGATGATTGACATTGAAGCCTGCGCACATACGGTCCATAAACATGGA GACATCATTTTGGTTGTGGATAACACTTTTATGTCAGCATATTTCCAGCGGCCTTTGTCT CTGGGAGCTGATATTTGTATGTATTCAGCAACAAAATACATGAATGGCTACAGTGATGTT GTAATGGGCTTAGTGTCACTGAATTCTGAGAGCCTTCATGATAGGCTCCGTTTCTTGCAA AATTCTCTTGGAGCAGTTCCATCTCCTATTGACTGTTACCTCTGCAATCGGGGTCTGAAG ACTCTACAAGTCCGCATGGAGAAGCATTTCGAAAACGGAATGGCAGTTGCTCAGTTTTTG GAGTCGAATCCTCAGGTGGAAAAGGTTATTTATCCTGGGCTGCCTTCTCATCCTCAGCAT GAGCTGGCCAAGCGTCAGTGCACAGGTTGCCCGGGGATGGTCACCTTTTATATCAAGGGC TCTCTTCAACATGCTGAAACTTTCCTCCAGAACTTAAAGTTATTTACTCTGGCTGAAAGC TTGGGAGGATACGAAAGTCTTGCTGAGCTTCCGGCAATCATGACCCATGCATCAGTGCCT AAGAGTGACAGAGAAGTCCTTGGAATTAGTGACACACTTATTCGACTCTCAGTGGGCTTA GAGGATAAACAAGACCTACTGGATGATCTAGATCAAGCTTTGAAGGCAGCTAACCCTCCA AATGCAAGTTCCAACTAG |
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| Protein Properties | |||||||||
| Number of Residues | 405 | ||||||||
| Molecular Weight | 44406.0 | ||||||||
| Theoretical pI | 6.39 | ||||||||
| Pfam Domain Function | Not Available | ||||||||
| Signals |
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| Transmembrane Regions | Not Available | ||||||||
| Protein Sequence |
>Cystathionine gamma-lyase MQEKEASPHGFLPRFQHFATQAIHVGQEPEQWTSQAVVPPISLSTTFKQGAPGQHSGFEY SRSGNPTRNCLEKAVAALDGAKYSLAFASGLAATVTITHLLKAGDQIICMDDVYGGTNRY FRQVATEFGLKISFVDCSKPKLLEAAITPETKLVWIETPTNPSLKMIDIEACAHTVHKHG DIILVVDNTFMSAYFQRPLSLGADICMYSATKYMNGYSDVVMGLVSLNSESLHDRLRFLQ NSLGAVPSPIDCYLCNRGLKTLQVRMEKHFENGMAVAQFLESNPQVEKVIYPGLPSHPQH ELAKRQCTGCPGMVTFYIKGSLQHAETFLQNLKLFTLAESLGGYESLAELPAIMTHASVP KSDREVLGISDTLIRLSVGLEDKQDLLDDLDQALKAANPPNASSN |
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| External Links | |||||||||
| GenBank ID Protein | AAX46332.1 | ||||||||
| UniProtKB/Swiss-Prot ID | Q58DW2 | ||||||||
| UniProtKB/Swiss-Prot Entry Name | CGL_BOVIN | ||||||||
| PDB IDs | Not Available | ||||||||
| GenBank Gene ID | BT021485 | ||||||||
| GeneCard ID | CTH | ||||||||
| GenAtlas ID | Not Available | ||||||||
| HGNC ID | Not Available | ||||||||
| References | |||||||||
| General References | Not Available | ||||||||