Showing Protein 72 kDa type IV collagenase (BMDBP00819)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00819 |
| Secondary Accession Numbers | None |
| Name | 72 kDa type IV collagenase |
| Synonyms | Not Available |
| Gene Name | MMP2 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in calcium ion binding |
| Specific Function | Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues (By similarity). |
| Pathways |
|
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 18 |
| Locus | Not Available |
| SNPs | MMP2 |
| Gene Sequence |
>1986 bp ATGACCGAGGCGCGAGTGTCCCGGGGCGCGCTGGCCGCCCTTCTGCGGGCGCTCTGCGCC CTGGGCTGCCTGTTGGGCCGTGCCGCCGCCGCGCCGTCGCCCATCATCAAATTTCCCGGC GATGTCGCCCCCAAAACGGACAAAGAGTTGGCTGTGCAATACCTAAACACCTTCTACGGC TGCCCCAAGGAGAGCTGTAACTTGTTTGTGCTGAAGGACACCCTGAAGAAGATGCAGAAG TTCTTCGGGTTACCCCAGACAGGTGAACTGGACCAGAGCACCATTGAGACCATGCGGAAG CCGCGCTGTGGCAACCCCGACGTGGCCAACTACAACTTCTTCCCCCGAAAGCCCAAGTGG GACAAGAACCAGATCACATACAGGATCATTGGCTACACACCTGATCTGGACCCCCAGACA GTGGATGATGCCTTCGCTCGTGCCTTCCAAGTCTGGAGCGATGTGACTCCGCTACGGTTT TCTCGGATCCATGATGGAGAGGCTGACATCATGATCAACTTTGGCCGCTGGGAGCATGGA GATGGGTACCCTTTTGATGGCAAAGACGGGCTCCTGGCTCATGCCTTCGCCCCGGGCCCT GGAGTTGGGGGAGATTCCCACTTTGATGACGATGAGCTGCGGACCCTGGGAGAAGGACAA GTGGTCCGTGTGAAGTACGGGAATGCTGACGGGGAATATTGCAAGTTCCCCTTCCGGTTC AACGGCAAGGAGTACACCAGCTGCACAGACACAGGCCGCAGCGATGGCTTCCTCTGGTGT TCCACCACATACAACTTTGACAAGGACGGCAAGTATGGCTTCTGCCCCCATGAAGCCCTG TTCACCATGGGCGGCAACGCCGACGGACAGCCCTGCAAGTTCCCGTTCCGCTTCCAGGGC ACGTCTTACGACAGTTGCACCACGGAGGGCCGCACGGACGGCTACCGCTGGTGTGGCACC ACCGAGGACTACGACCGCGACAAGGAGTACGGCTTCTGCCCGGAGACCGCCATGTCCACT GTGGGCGGGAACTCGGAAGGTGCCCCATGTGTCCTCCCCTTCACCTTCCTGGGCAACAAG CACGAGAGCTGCACCAGCGCTGGCCGCAGTGATGGGAAGTTGTGGTGTGCGACCACCTCC AACTACGATGATGACCGCAAGTGGGGCTTCTGCCCCGACCAAGGGTACAGCCTGTTCCTG GTGGCAGCCCATGAGTTTGGCCATGCAATGGGGCTGGAGCACTCACAGGACCCTGGAGCC CTGATGGCGCCCATTTATACCTACACCAAGAACTTCCGCCTGTCCCATGATGACATCCAG GGCATCCAAGAACTCTATGGGGCCTCCCCTGACATTGATACTGGCACCGGCCCCACCCCA ACCCTGGGCCCCGTCACTCCTGAGCTCTGCAAACAGGACATCGTCTTCGACGGCATCTCT CAGATCCGTGGGGAGATCTTCTTCTTCAAGGACCGATTCATCTGGCGAACAGTGACACCA CGTGACAAGCCCACAGGGCCCCTGCTGGTAGCCACATTCTGGCCTGAGCTGCCGGAAAAG ATCGATGCTGTGTACGAAGACCCACAGGAGGAGAAGGCTGTGTTCTTTGCAGGGAACGAA TACTGGGTCTATTCAGCCAGCACCCTGGAGCGAGGGTACCCCAAGCCACTGACCAGCCTG GGGCTCCCCCCTGGTGTCCAGAAGGTGGATGCTGCCTTTAACTGGAGCAAGAACAAGAAG ACGTACATCTTCGCCGGAGACAAATTCTGGAGATACAATGAGGTGAAGAAGAAAATGGAT CCTGGCTTCCCCAAGCTCATCGCCGATGCCTGGAACGCCATCCCTGATAACCTGGATGCT GTGGTGGACCTGCAGGGCGGGGGTCACAGCTACTTCTTCAAGGGCGCCTATTACCTGAAG TTGGAGAACCAAAGTCTGAAGAGCGTGAAGTTCGGAAGCATCAAATCCGATTGGCTGGGC TGCTGA |
| Protein Properties | |
| Number of Residues | 661 |
| Molecular Weight | 73777.0 |
| Theoretical pI | 5.34 |
| Pfam Domain Function | Not Available |
| Signals |
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| Transmembrane Regions | Not Available |
| Protein Sequence |
>72 kDa type IV collagenase MTEARVSRGALAALLRALCALGCLLGRAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYG CPKESCNLFVLKDTLKKMQKFFGLPQTGELDQSTIETMRKPRCGNPDVANYNFFPRKPKW DKNQITYRIIGYTPDLDPQTVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHG DGYPFDGKDGLLAHAFAPGPGVGGDSHFDDDELRTLGEGQVVRVKYGNADGEYCKFPFRF NGKEYTSCTDTGRSDGFLWCSTTYNFDKDGKYGFCPHEALFTMGGNADGQPCKFPFRFQG TSYDSCTTEGRTDGYRWCGTTEDYDRDKEYGFCPETAMSTVGGNSEGAPCVLPFTFLGNK HESCTSAGRSDGKLWCATTSNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGA LMAPIYTYTKNFRLSHDDIQGIQELYGASPDIDTGTGPTPTLGPVTPELCKQDIVFDGIS QIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEDPQEEKAVFFAGNE YWVYSASTLERGYPKPLTSLGLPPGVQKVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMD PGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLG C |
| External Links | |
| GenBank ID Protein | AAG28169.1 |
| UniProtKB/Swiss-Prot ID | Q9GLE5 |
| UniProtKB/Swiss-Prot Entry Name | MMP2_BOVIN |
| PDB IDs | |
| GenBank Gene ID | AF290428 |
| GeneCard ID | MMP2 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |