| Identification |
|---|
| BMDB Protein ID
| BMDBP00819 |
| Secondary Accession Numbers
| None |
| Name
| 72 kDa type IV collagenase |
| Synonyms
|
Not Available
|
| Gene Name
| MMP2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues (By similarity). |
| Pathways
|
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| Not Available |
| SNPs
| MMP2 |
| Gene Sequence
|
>1986 bp
ATGACCGAGGCGCGAGTGTCCCGGGGCGCGCTGGCCGCCCTTCTGCGGGCGCTCTGCGCC
CTGGGCTGCCTGTTGGGCCGTGCCGCCGCCGCGCCGTCGCCCATCATCAAATTTCCCGGC
GATGTCGCCCCCAAAACGGACAAAGAGTTGGCTGTGCAATACCTAAACACCTTCTACGGC
TGCCCCAAGGAGAGCTGTAACTTGTTTGTGCTGAAGGACACCCTGAAGAAGATGCAGAAG
TTCTTCGGGTTACCCCAGACAGGTGAACTGGACCAGAGCACCATTGAGACCATGCGGAAG
CCGCGCTGTGGCAACCCCGACGTGGCCAACTACAACTTCTTCCCCCGAAAGCCCAAGTGG
GACAAGAACCAGATCACATACAGGATCATTGGCTACACACCTGATCTGGACCCCCAGACA
GTGGATGATGCCTTCGCTCGTGCCTTCCAAGTCTGGAGCGATGTGACTCCGCTACGGTTT
TCTCGGATCCATGATGGAGAGGCTGACATCATGATCAACTTTGGCCGCTGGGAGCATGGA
GATGGGTACCCTTTTGATGGCAAAGACGGGCTCCTGGCTCATGCCTTCGCCCCGGGCCCT
GGAGTTGGGGGAGATTCCCACTTTGATGACGATGAGCTGCGGACCCTGGGAGAAGGACAA
GTGGTCCGTGTGAAGTACGGGAATGCTGACGGGGAATATTGCAAGTTCCCCTTCCGGTTC
AACGGCAAGGAGTACACCAGCTGCACAGACACAGGCCGCAGCGATGGCTTCCTCTGGTGT
TCCACCACATACAACTTTGACAAGGACGGCAAGTATGGCTTCTGCCCCCATGAAGCCCTG
TTCACCATGGGCGGCAACGCCGACGGACAGCCCTGCAAGTTCCCGTTCCGCTTCCAGGGC
ACGTCTTACGACAGTTGCACCACGGAGGGCCGCACGGACGGCTACCGCTGGTGTGGCACC
ACCGAGGACTACGACCGCGACAAGGAGTACGGCTTCTGCCCGGAGACCGCCATGTCCACT
GTGGGCGGGAACTCGGAAGGTGCCCCATGTGTCCTCCCCTTCACCTTCCTGGGCAACAAG
CACGAGAGCTGCACCAGCGCTGGCCGCAGTGATGGGAAGTTGTGGTGTGCGACCACCTCC
AACTACGATGATGACCGCAAGTGGGGCTTCTGCCCCGACCAAGGGTACAGCCTGTTCCTG
GTGGCAGCCCATGAGTTTGGCCATGCAATGGGGCTGGAGCACTCACAGGACCCTGGAGCC
CTGATGGCGCCCATTTATACCTACACCAAGAACTTCCGCCTGTCCCATGATGACATCCAG
GGCATCCAAGAACTCTATGGGGCCTCCCCTGACATTGATACTGGCACCGGCCCCACCCCA
ACCCTGGGCCCCGTCACTCCTGAGCTCTGCAAACAGGACATCGTCTTCGACGGCATCTCT
CAGATCCGTGGGGAGATCTTCTTCTTCAAGGACCGATTCATCTGGCGAACAGTGACACCA
CGTGACAAGCCCACAGGGCCCCTGCTGGTAGCCACATTCTGGCCTGAGCTGCCGGAAAAG
ATCGATGCTGTGTACGAAGACCCACAGGAGGAGAAGGCTGTGTTCTTTGCAGGGAACGAA
TACTGGGTCTATTCAGCCAGCACCCTGGAGCGAGGGTACCCCAAGCCACTGACCAGCCTG
GGGCTCCCCCCTGGTGTCCAGAAGGTGGATGCTGCCTTTAACTGGAGCAAGAACAAGAAG
ACGTACATCTTCGCCGGAGACAAATTCTGGAGATACAATGAGGTGAAGAAGAAAATGGAT
CCTGGCTTCCCCAAGCTCATCGCCGATGCCTGGAACGCCATCCCTGATAACCTGGATGCT
GTGGTGGACCTGCAGGGCGGGGGTCACAGCTACTTCTTCAAGGGCGCCTATTACCTGAAG
TTGGAGAACCAAAGTCTGAAGAGCGTGAAGTTCGGAAGCATCAAATCCGATTGGCTGGGC
TGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 661 |
| Molecular Weight
| 73777.0 |
| Theoretical pI
| 5.34 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>72 kDa type IV collagenase
MTEARVSRGALAALLRALCALGCLLGRAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYG
CPKESCNLFVLKDTLKKMQKFFGLPQTGELDQSTIETMRKPRCGNPDVANYNFFPRKPKW
DKNQITYRIIGYTPDLDPQTVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHG
DGYPFDGKDGLLAHAFAPGPGVGGDSHFDDDELRTLGEGQVVRVKYGNADGEYCKFPFRF
NGKEYTSCTDTGRSDGFLWCSTTYNFDKDGKYGFCPHEALFTMGGNADGQPCKFPFRFQG
TSYDSCTTEGRTDGYRWCGTTEDYDRDKEYGFCPETAMSTVGGNSEGAPCVLPFTFLGNK
HESCTSAGRSDGKLWCATTSNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGA
LMAPIYTYTKNFRLSHDDIQGIQELYGASPDIDTGTGPTPTLGPVTPELCKQDIVFDGIS
QIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEDPQEEKAVFFAGNE
YWVYSASTLERGYPKPLTSLGLPPGVQKVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMD
PGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLG
C
|
| External Links |
|---|
| GenBank ID Protein
| AAG28169.1 |
| UniProtKB/Swiss-Prot ID
| Q9GLE5 |
| UniProtKB/Swiss-Prot Entry Name
| MMP2_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| AF290428 |
| GeneCard ID
| MMP2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
