Showing Protein A disintegrin and metalloproteinase with thrombospondin motifs 4 (BMDBP00820)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00820 |
| Secondary Accession Numbers | None |
| Name | A disintegrin and metalloproteinase with thrombospondin motifs 4 |
| Synonyms | Not Available |
| Gene Name | ADAMTS4 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in metalloendopeptidase activity |
| Specific Function | Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Cleaves aggrecan at the '392-Glu-|-Ala-393' site. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 3 |
| Locus | Not Available |
| SNPs | ADAMTS4 |
| Gene Sequence |
>2520 bp ATGTCCCACATGGACTCGCATCCCGGGAGGGGCTTGGCGGACGGCTGGCTGTGGGGAATC CAACCCCGCCTGCTGCTCCCCACTGTGCCCGTCTCCGGCTCCAGGCTAGTGTGGCTGCTG CTGCTAGCCTCCCTCCTGCCCTCAGCCTGGCCGGCCAGCCCCCTCCCCCGGGAGGAGGAG ATCGTGTTTCCAGAGAAGCTCAACGGCAGCGTCCTGCCTGGTTTGGGCGCCCCTGCCAGG CTGTTGTACCGCTTGCCAGCCTTTGGGGAGACGCTGCTGCTAGAGCTGGAGAAGGACCCC GGCGTGCAGGTTGAGGGGCTGACGGTGCAATACTTGGGCCGAGCGCCTGAGCTGCTAGGT GGGGCGGAGCCAGGCACCTACCTCACCGGCACCATCAACGGAGATCCGGAGTCGGTGGCA TCTCTGCACTGGGACGGGGGAGCACTTTTAGGGGTGCTGCAGTACCGAGGGACTGAACTC CACATCCAGCCCCTGGAGGGAGGCGCGCCTAACTCCGCTGGGGGGCCTGGGGCTCACATC CTACGCCGGAAGAGTCCTGTCAGCGGCCAGGGCCCCATGTGCAACGTCAAGGCTCCTCCT GGGAAACCCAGCCCCAGCCCCCGAAGGGCTAAGCGCTTTGCCTCACTGAGCAGATTTGTG GAGACTCTGGTGGTGGCAGATGACAAGATGGCGGCATTCCATGGTGCAGGGCTCAAGCGC TACCTGCTGACAGTTATGGCAGCGGCGGCCAAGGCCTTCAAGCACCCGAGCATCCGCAAC CCCGTCAGCTTGGTGGTGACTCGGCTAGTGGTTCTGGGGCCAGGTGAGGAAGGGCCCCAA GTGGGCCCCAGTGCCGCCCAGACCCTGCGCAGCTTCTGTGCCTGGCAACGAGGACTCAAC ACCCCTGACGACGCGGACCCTGGCCACTTTGACACAGCCATTCTGTTTACCCGGCAGGAC CTGTGCGGAGTTTCTACCTGTGACACTCTAGGCATGGCTGACGTGGGCACCGTGTGTGAC CCTGCCCGGAGCTGCGCCATTGTGGAGGATGATGGGCTGCAGTCAGCTTTCACCGCTGCT CATGAACTGGGCCATGTCTTCAGCATGCTCCATGACAACTCGAAGCAATGCACTGGTCTG AATGGGCCTGAGAGCACCTCCCGCCACGTCATGGCTCCTGTGATGGCTCACGTGGATCCC GAGGAGCCCTGGTCCCCCTGCAGCGCCCGCTTCATCACTGACTTCCTAGACAATGGCTTC GGGCACTGTCTCCTAGACAAGCCGGAGGCTCCTCTGCATCTGCCCGTGACCTTCCCCGGC AAGGACTACGACGCTGACCGCCAGTGCCAGCTGACCTTTGGGCCTGACTCGCGCCATTGT CCACAGCTGCCGCCGCCCTGTGCTGCCCTCTGGTGCTCTGGCCATCTGAATGGCCATGCC ATGTGCCAGACTAAGCACTCACCCTGGGCCGACGGTACCCCTTGCGGGCCCGCACAGGCT TGTATGGGTGGCCGCTGCCTCCATGTGGACCAGCTCCAGGCTTTCAATGTCCCACAGGCT GGTGGCTGGGGTCCCTGGGGATCGTGGGGTGACTGCTCTCGGAGCTGTGGGGGTGGTGTC CAGTTCTCTTCCCGGGACTGCACACGGCCCGTCCCCCGGAATGGTGGCAAGTACTGTGAG GGCCGCCGTACCCGCTTCCGTTCCTGCAACACCCAGGACTGCCCAACTGGCTCAGCACTG ACCTTCCGCGAAGAGCAGTGTGCTGCCTACAACCACCGCACTGACCTCTTCAAGAACTTC CCCGGGCCCATGGACTGGGTTCCTCGCTACACTGGTGTGGCCCCCCGGGACCAGTGCAAA CTCACCTGCCAGACCCGGGCACTGGGCTACTATTACGTGCTGGACCCACGGGTGGCAGAT GGGACCCCCTGTTCCCCGGACAGCTCCTCAGTCTGTGTCCAGGGCCGCTGCATCCATGCC GGCTGTGACCGCGTCATTGGCTCCAAAAAGAAGTTCGACAAGTGCATGGTGTGTGGTGGG GATGGTTCCAGCTGCAGCAAGCAGTCTGGCTCCTTCAAAAAATTCAGGTACGGATACAAC AACGTGGTCACCATCCCCGCTGGGGCCACCCACATCCTGGTGCGACAGCAGGGGAGCCCT AGCGTCCGGAGCCTCTACCTGGCCCTGAAGCTCCCCGATGGCTCCTATGCCCTCAACGGT GAATACACGCTGATCCCGTCCCCCACAGACGTGGTACTGCCCGGGGCCGTCAGCCTGCGC TACAGCGGGGCCACTGCAGCCTCGGAGACACTGTCAGGACACGGGCCCCTGGCTGAGCCC TTAACGCTGCAGGTCCTAGTGGCTGGCAACCCGCAGAACGCCCGCCTCAGATACAGCTTC TTCGTGCCGCGACCGCGACCGGTCCCCTCCACGCCACGCCCCACTCCCCAGGACTGGCTG CGCCGCAAGTCACAGATTCTGGAGATCCTCCGGCGGCGCTCCTGGGCCGGCAGGAAATAA |
| Protein Properties | |
| Number of Residues | 839 |
| Molecular Weight | 90280.0 |
| Theoretical pI | 8.24 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>A disintegrin and metalloproteinase with thrombospondin motifs 4 MSHMDSHPGRGLADGWLWGIQPRLLLPTVPVSGSRLVWLLLLASLLPSAWPASPLPREEE IVFPEKLNGSVLPGLGAPARLLYRLPAFGETLLLELEKDPGVQVEGLTVQYLGRAPELLG GAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYRGTELHIQPLEGGAPNSAGGPGAHI LRRKSPVSGQGPMCNVKAPPGKPSPSPRRAKRFASLSRFVETLVVADDKMAAFHGAGLKR YLLTVMAAAAKAFKHPSIRNPVSLVVTRLVVLGPGEEGPQVGPSAAQTLRSFCAWQRGLN TPDDADPGHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAA HELGHVFSMLHDNSKQCTGLNGPESTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGF GHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHA MCQTKHSPWADGTPCGPAQACMGGRCLHVDQLQAFNVPQAGGWGPWGSWGDCSRSCGGGV QFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTQDCPTGSALTFREEQCAAYNHRTDLFKNF PGPMDWVPRYTGVAPRDQCKLTCQTRALGYYYVLDPRVADGTPCSPDSSSVCVQGRCIHA GCDRVIGSKKKFDKCMVCGGDGSSCSKQSGSFKKFRYGYNNVVTIPAGATHILVRQQGSP SVRSLYLALKLPDGSYALNGEYTLIPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAEP LTLQVLVAGNPQNARLRYSFFVPRPRPVPSTPRPTPQDWLRRKSQILEILRRRSWAGRK |
| External Links | |
| GenBank ID Protein | AAP47196.1 |
| UniProtKB/Swiss-Prot ID | Q9TT93 |
| UniProtKB/Swiss-Prot Entry Name | ATS4_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | AF516915 |
| GeneCard ID | ADAMTS4 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |