| Identification |
|---|
| BMDB Protein ID
| BMDBP00821 |
| Secondary Accession Numbers
| |
| Name
| Dihydrofolate reductase |
| Synonyms
|
Not Available
|
| Gene Name
| DHFR |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Coenzyme transport and metabolism |
| Specific Function
| Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2 (By similarity). |
| Pathways
|
- 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1
- Cofactor biosynthesis
- Tetrahydrofolate biosynthesis
|
| Reactions
|
| Tetrahydrofolic acid + NADP → Dihydrofolic acid + NADPH |
details
|
| Dihydrofolic acid + NADP → Folic acid + NADPH |
details
|
| 7,8-Dihydroneopterin + NADPH → NADP + Tetrahydrobiopterin + Water |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| DHFR |
| Gene Sequence
|
>564 bp
ATGGTTCGTCCACTAAACTGCATCGTTGCTGTGTCCCAGAACATGGGTATCGGCAAGAAC
GGAAACCTGCCCTGGCCACCGCTCAGGAATGAATTCCAGTATTTCCAGAGAATGACTACA
GTCTCTTCAGTAGAAGGTAAACAGAATTTGGTGATTATGGGTAGGAAGACCTGGTTCTCC
ATTCCAGAGAAGAATCGACCTTTAAAGGACAGAATTAACATAGTTCTCAGTAGAGAACTC
AAGGAACCTCCAAAGGGAGCTCATTTTCTTGCCAAAAGTCTGGATGATGCCTTAGAACTT
ATTGAAGATCCAGAATTAACAAATAAAGTAGACGTGGTTTGGATAGTGGGAGGCAGTTCT
GTTTATAAGGAAGCCATGAACAAGCCAGGCCATGTTAGACTATTTGTGACAAGGATCATG
CAAGAATTTGAAAGTGATGCGTTTTTCCCAGAAATTGATTTTGAAAAATATAAACTTCTT
CCAGAATATCCAGGTGTTCCTTTGGATGTCCAAGAGGAAAAAGGCATTAAGTACAAATTT
GAAGTATATGAAAAGAACAATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 187 |
| Molecular Weight
| 21604.0 |
| Theoretical pI
| 6.55 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Dihydrofolate reductase
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFQYFQRMTTVSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPKGAHFLAKSLDDALELIEDPELTNKVDVVWIVGGSS
VYKEAMNKPGHVRLFVTRIMQEFESDAFFPEIDFEKYKLLPEYPGVPLDVQEEKGIKYKF
EVYEKNN
|
| External Links |
|---|
| GenBank ID Protein
| AAI14163.1 |
| UniProtKB/Swiss-Prot ID
| P00376 |
| UniProtKB/Swiss-Prot Entry Name
| DYR_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC114162 |
| GeneCard ID
| DHFR |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
