Showing Protein Aprataxin and PNK-like factor (BMDBP00825)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00825 |
| Secondary Accession Numbers | None |
| Name | Aprataxin and PNK-like factor |
| Synonyms | Not Available |
| Gene Name | APLF |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in 3'-5' exonuclease activity |
| Specific Function | Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage. Together with PARP3, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 11 |
| Locus | Not Available |
| SNPs | APLF |
| Gene Sequence |
>1458 bp ATGTCCGGGGGCTTCGAGCTGCAGCCGCAGGACGGCGGCCCCCGGGTGGCCTTGGCGCCC GGGGAGACGGTCATCGGCCGCGGGCCGCTTCTGGGACTACACAGAAATCCATGTTATTAT CAGTCTTCTGAGAAGAGCCAGCTCTTACCATTGAAGACAAATATATGGTGCTGGTTGAAT CCTGGAGATCACTTTTCTTTATTAGTTGACAAATACATTTTCTGTGTCTTGTCTACACAT TCTGAAATGGAAATGGAGTGTACTTTAAGAAATAGTCAAATGCTTGATGAAGATGATATA TTGAATGAAATACCAAAATCTTCCTCAGCTGATTTGCCTGATAAAACACCCAGTGCCCCA CGGCGGGAAAGAAGTACAGAAACAGCAAAGCCCCAGGCCGCTGCAAATAACATGTCTTTC ATAGGTGAAAGTAGAGACTTGAGTAAGCAACAGCCAAATCCTTCCGAGAGGAAAAGAATC CTCCCAGCATGGATGTTAACAGAAAATTCAAGTGATCAGAACCTTTCAGTCATCAGTGGA GGTAATAATGTAACCTGGGAAAGTGAAAAAGAAAGAGTCTGCAAAGATAAAACCCAAGTA AACATAACACAGCCAGGAAAAAAGCGATTAATTTCATCAGGAAGTTCAGAAAGTACATCA GCAAAGCAAGACACAGGAAAAAAGTGCAAAAATGATGATCAGGAAGAGTCTATCATTTCA TCCAAGGAAATGCCACAGTCATTTTCTGCAGCCATGTTACATAACACAGAGATAGATAAC ACTAAGACTAATCCACAGAGAAGCAAAGTCCCAGTAGAGGCACTTGGTAAGGTTTCTGAA CATAAAATCATCACTAAGGGAAGTTCAAATGAAGACAGCACGGCGAGAAGTTGTTCTGAG AGTTATTCCAGTACCCAGAGCAAGTCTTTCTGTGACAAGCCTCAAAAATCTCATCCTGAG CCCAGCTCTAATCCGCCCAGTCCTGAATGTGTGCAGGCGAAGGCAACCGATTCAGTTCCA AATGGTTCTGAAGAAAACAAGGTACAGAGAACATCCTGCATGTATGGGGCAAACTGCTAC AGGAAAAATCCTGTCCATTTTCAACACTTCAGTCACCCTGGTGATAGTGATTATGGAGGT GTAAACATCACGTGTCAAGATGAAGCTGATGACCGACCTGAATGTCCCTATGGAGCATCT TGTTATAGGAAGAATCCCCAGCACAAGATAGAATATAGACATAGTACATTTCCAGTGAGA AGCATTTCAGATGAAGATGACAATGTTGGGCAACCCAATGAATACAACCTGAATGACAGC TTTATAGATGATGAGGAAGAAGAATACGAGCCAACAGACGAAGATTCCGACTGGGAACCA GAAAAGGAAGACCTAGAGAAGGAAGATATGGAAGGGCTTTTGAAAGAAGCAAAAAAATTT ATGAAAAGAAAAAAGTGA |
| Protein Properties | |
| Number of Residues | 485 |
| Molecular Weight | 54326.0 |
| Theoretical pI | 4.87 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions |
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| Protein Sequence |
>Aprataxin and PNK-like factor MSGGFELQPQDGGPRVALAPGETVIGRGPLLGLHRNPCYYQSSEKSQLLPLKTNIWCWLN PGDHFSLLVDKYIFCVLSTHSEMEMECTLRNSQMLDEDDILNEIPKSSSADLPDKTPSAP RRERSTETAKPQAAANNMSFIGESRDLSKQQPNPSERKRILPAWMLTENSSDQNLSVISG GNNVTWESEKERVCKDKTQVNITQPGKKRLISSGSSESTSAKQDTGKKCKNDDQEESIIS SKEMPQSFSAAMLHNTEIDNTKTNPQRSKVPVEALGKVSEHKIITKGSSNEDSTARSCSE SYSSTQSKSFCDKPQKSHPEPSSNPPSPECVQAKATDSVPNGSEENKVQRTSCMYGANCY RKNPVHFQHFSHPGDSDYGGVNITCQDEADDRPECPYGASCYRKNPQHKIEYRHSTFPVR SISDEDDNVGQPNEYNLNDSFIDDEEEEYEPTDEDSDWEPEKEDLEKEDMEGLLKEAKKF MKRKK |
| External Links | |
| GenBank ID Protein | AAI26692.1 |
| UniProtKB/Swiss-Prot ID | A0JNH9 |
| UniProtKB/Swiss-Prot Entry Name | APLF_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC126691 |
| GeneCard ID | APLF |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |