| Identification |
|---|
| BMDB Protein ID
| BMDBP00826 |
| Secondary Accession Numbers
| None |
| Name
| Secretory phospholipase A2 receptor |
| Synonyms
|
Not Available
|
| Gene Name
| PLA2R1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in receptor activity |
| Specific Function
| Receptor for secretory phospholipase A2 (sPLA2). Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B and sPLA2-X/PLA2G10. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| Not Available |
| SNPs
| PLA2R1 |
| Gene Sequence
|
>4392 bp
ATGCCGCTGCTGTCGCTGTCGCTGCTCCTGCTGCTGCTGCAGGTACCGGCGGGCTCCGCC
GAGACCGCGGCGTGGGCAGTCACCCCCGAGCGGCTCCGCGAGTGGCAAGATAAAGGAATC
TTCATTATCCAAAGTGAGAACCTCGAGAAATGTATTCAAGCCAGCAAATCTACACTGACC
CTGGAGAACTGCAAACCACCCAACAAGTACATGCTGTGGAAGTGGGTTTCAAACCACCGC
TTATTTAACATCGGAGGCAGTGGCTGCCTGGGCCTGAACGTGTCTAGTCCAGAGCAGCCA
CTGAGCATATACGAGTGTGATTCCACCCACGTTTCCTTGAAGTGGCACTGTAACAAGAAG
ACGATCACAGGCCCACTCCAGTACCTGGTCCAGGTGAAGCAGGACAACACGCTTGTGGCC
TCAAGGAAATATCTCCATAAGTGGGTTTCCTATATGTCCGGCGGTGGAGGCATTTGTGAC
TATCTGCACAAAGATTTGTACACAATCAAAGGGAATGCCCATGGGACTCCGTGCATGTTC
CCCTTCCAGTACAATCAGCAGTGGCACCACGAATGTACCCGGGAAGGACGGGAAGACAAC
TTGCTGTGGTGTGCCACTACCAGCCGATACGAAAGAGACGAGAAGTGGGGATTTTGCCCA
GATCCTACATCCACAGAGGTGGGCTGCGATGCAGTCTGGGAGAAGGATCTCCATTCACGC
ATTTGCTACCAATTCAATCTGCTTTCCTCCCTGTCCTGGAGTGAGGCTCATTCTTCATGC
CAGATGCAAGGAGCTGCTTTATTAAGTATTGCAGATGAGACTGAAGAAAATTTCGTAAGG
AAGCACTTGGGCAGTGAAGCAGTGGAAGTATGGATGGGTCTGAATCAGCTGGATGAAGAT
GCTGGTTGGCAGTGGTCTGATAGAACACCACTCAACTATCTGAACTGGAAGCCAGAAATA
AATTTTGAGCCATTTGTTGAATATCACTGTGGAACATTTAATGCATTTATGCCAAAGGCC
TGGAAAAGTCGGGATTGTGAGTCTACCTTGCCCTACGTGTGTAAAAAATATCTAAATCCC
ACTGATCATGGAGTAGTTGAAAAGGATGCTTGGAAATACTATGCTACCCACTGTGAGCCT
GGCTGGAATCCCCACAACCGTAATTGCTATAAACTGCAGAAAGAAAAAAAGACCTGGAAT
GAGGCTTTGCAGTCTTGCCAGTCCAACAACAGTGTATTAACAGACATCACTTCGTTAGCA
GAGGTGGAGTTTCTTGTAACCCTCCTTGGAGATGAAAATGCATCAGAAACATGGATTGGT
TTGAGCAGCCATAAAATTCCAGTTTCCTTTGAGTGGTCTAATGGCTCCTCGGTCACCTTT
ACTAACTGGCACACACTTGAGCCCCACATTTTTCCAAATAGAAGCCAGTTGTGTGTCTCA
GCAGAGCAATCTGAGGGACACTGGAAAGTTAAAAATTGCGAAGAAACACTTTTTTACCTT
TGTAAGAAAACAGGCCTTGTCCTTTCTGACACTGAATCAGGCTGTCAAAAGGGATGGGAG
AGACATGGTAAATTCTGTTACAAAATTGACACCGTCCTTCGAAGCTTTGACCATGCCTCC
AGTGGTTACTACTGTCCTCCTGCGCTTATAACCATTACAAGCAGGTTTGAACAGGCTTTT
ATTACCAGTTTGATCAGTAGTGTGGTAAAAACGAAGGACACTTATTTTTGGATCGCTCTT
CAAGATCAAAATAATACAGGAGAATACACTTGGAAGACGGCAGGGCAGCAGTTGGAGCCA
GTGAAGTACACACACTGGAACACACGTCAGCCCCGCTACAGTGGTGGCTGCGTTGTCATG
CGAGGGAGGAGTCACCCTGGCCGCTGGGAAGTGAGGGACTGTAGGCACTTTAAGGCGATG
TCCCTGTGCAAGCAACCAGTGGAAAATCGGGAGAAAACCAAGCAAGAAGAGGGATGGCCC
TTTCACCCCTGCTATTTGGATTGGGAGTCAGAGCCTGGCCTGGCCAGTTGCTTCAAGGTA
TTTCATAGTGAAAAAGTCCTGATGAAAAGAACATGGAGACAAGCTGAAGAATTTTGTGAA
GAATTTGGAGCTCATCTTGCAAGCTTTGCCCATATTGAGGAAGAGAATTTTGTGAATGAG
CTTTTACATTCAAAATTTAATCGGACAGAAGAAAGGCAGTTCTGGATTGGATTTAATAAA
AGAAACCCACTGAATGCTGGTTCTTGGGAATGGTCTGATGGAACTCCTGTTGTCTCTTCA
TTTTTAGACAATTCTTATTTTGGAGAAGATGCAAGAAATTGTGCTGTTTATAAGGCAAAT
AAAACGTTGCTACCCTCATACTGTGGTTCCAAACGTGAATGGATATGCAAAATTCCAAGA
GATGTGAGACCCAAGGTTCCACCCTGGTATCAGTATGATGCACCCTGGCTCTTTTATCAG
GATGCAGAGTACCTTTTTCATATTTCTGCCTCAGAATGGTCCTCCTTTGAGTTTGTCTGT
GGCTGGCTGCGCAGTGATATTCTCACTATTCATTCTGCACACGAACAAGAATTCATCCAC
AGCAAAATAAGAGCGCTATCAAAGTATGGTGTAAATTGGTGGATTGGACTTCGAGAAGAA
AGAGCCAGTGATGAATTTCGTTGGAGAGATGGATCACCAGTAATATATCAGAACTGGGAC
AAAGGAAAAGAAAGATCTATGGGCCTTAATGAGAGCCAGAGGTGTGGCTTCATTTCATCC
ATAACAGGTCTCTGGGCGAGTGAAGAGTGTTCAATTTCTATGCCTAGCATCTGTAAGCGA
AAAAAGGTTTGGGTCATAGAAAAAAAGAAAGATATTCCAAAACAACATGGAACATGTCCC
AAAGGATGGTTATATTTTGACTATAAGTGCCTTTTGCTGAAAATCCCTGAAGGCCCAAGT
GACTGGAAGAACTGGACATCTGCTCAAGATTTTTGTGTTGAAGAAGGGGGGACACTGGTT
GCCATTGAAAATGAGGTGGAACAAGCTTTCATTACCATGAATCTTTTTGGCCATACCACT
AATGTGTGGATAGGGTTACAAGATGATGATTATGAAAAATGGCTAAATGGAAGGCCTGTG
TCATATTCTAATTGGTCTCCATTTGATACAAAAAATATTCCAAATCACAACACCACTGAA
GTTCAAAAACGCATTCCTCTCTGTGGCTTGCTGTCAAATAATCCTAATTTTCATTTCACT
GGAAAATGGTATTTTGAAGACTGTAGAGAAGGTTATGGGTTTGTTTGTGAAAAAATGCAG
GATGCTTCTGGACACAGTATAAATACATCTGATATGTATCCAATCCCTAATACCTTAGAA
TATGGAAACAGAACTTACAAAATAATTAATGCAAATATGACTTGGTATACAGCACTAAAA
ACCTGCCTGATGCATGGAGCAGAACTGGCCAGCATTACAGACCAGTACCACCAGTCTTTC
CTCACTGTTATCCTTAACCGGGTGGGATATGCCCACTGGATTGGACTGTTCACTGAAGAT
AATGGTCTTAGTTTTGACTGGTCAGATGGCACCAAATCCTCCTTCACTTTTTGGAAAGAT
GATGAATCATCCTTCCTTGGTGACTGTGTTTTTGCTGACACCAGTGGACGCTGGAGTAGC
ACAGCCTGCGAGTCGTATCTGCAAGGAGCCATTTGTCAAGTGCCCACTGAAACAAGACTG
TCTGGACGCCTAGAGTTGTGCTCAGAAACATCAATTCCCTGGATAAAATTCAAAAGTAAT
TGCTACAGTTTTTCTACAGTCCTAGAGAGTACAAGTTTTGAGGCTGCTCATGAATTTTGC
AAAAAGAAAGGCTCTAATCTTTTAACAATCAAAGATGAAGCTGAAAACTCTTTTCTTCTA
GAAGAGCTTTTAGCTTTCCGTTCTTCAGTCCAGATGATTTGGCTGAATGCTCAGTTTGAT
GGTGACAATGAAACCATAAAGTGGTTTGATGGAACTCCCACAGATCAATCAAACTGGGGT
ATTCGGAAGCCAGAGGTGTACCACTTCAAACCCCATCTGTGTGTTGCCCTGAGGATTCCT
GAAGGAGTGTGGCAATTATCCTCGTGTCAAGACAAAAAGGGATTTATATGTAAAATGGAA
GCAGATATTCACACAGTAAAGAAGCATCCAGGAAAAGGACCAAGTCACAGTGTTATACCT
CTTACAGTAGCACTGACACTGCTAGTAATTCTGGCAATTTCCACACTTTCCTTCTGCATG
TACAAGCACAGTCACATTATCTTCGGGAGACTTGCTCAGTTTAGAAATCCTTACTATCCT
TCAGCCAACTTTAGTACAGTACATTTAGAAGAAAATATTCTCATTTCTGATCTTGAGAAG
AATGACCAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 1463 |
| Molecular Weight
| 168651.0 |
| Theoretical pI
| 6.5 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Secretory phospholipase A2 receptor
MPLLSLSLLLLLLQVPAGSAETAAWAVTPERLREWQDKGIFIIQSENLEKCIQASKSTLT
LENCKPPNKYMLWKWVSNHRLFNIGGSGCLGLNVSSPEQPLSIYECDSTHVSLKWHCNKK
TITGPLQYLVQVKQDNTLVASRKYLHKWVSYMSGGGGICDYLHKDLYTIKGNAHGTPCMF
PFQYNQQWHHECTREGREDNLLWCATTSRYERDEKWGFCPDPTSTEVGCDAVWEKDLHSR
ICYQFNLLSSLSWSEAHSSCQMQGAALLSIADETEENFVRKHLGSEAVEVWMGLNQLDED
AGWQWSDRTPLNYLNWKPEINFEPFVEYHCGTFNAFMPKAWKSRDCESTLPYVCKKYLNP
TDHGVVEKDAWKYYATHCEPGWNPHNRNCYKLQKEKKTWNEALQSCQSNNSVLTDITSLA
EVEFLVTLLGDENASETWIGLSSHKIPVSFEWSNGSSVTFTNWHTLEPHIFPNRSQLCVS
AEQSEGHWKVKNCEETLFYLCKKTGLVLSDTESGCQKGWERHGKFCYKIDTVLRSFDHAS
SGYYCPPALITITSRFEQAFITSLISSVVKTKDTYFWIALQDQNNTGEYTWKTAGQQLEP
VKYTHWNTRQPRYSGGCVVMRGRSHPGRWEVRDCRHFKAMSLCKQPVENREKTKQEEGWP
FHPCYLDWESEPGLASCFKVFHSEKVLMKRTWRQAEEFCEEFGAHLASFAHIEEENFVNE
LLHSKFNRTEERQFWIGFNKRNPLNAGSWEWSDGTPVVSSFLDNSYFGEDARNCAVYKAN
KTLLPSYCGSKREWICKIPRDVRPKVPPWYQYDAPWLFYQDAEYLFHISASEWSSFEFVC
GWLRSDILTIHSAHEQEFIHSKIRALSKYGVNWWIGLREERASDEFRWRDGSPVIYQNWD
KGKERSMGLNESQRCGFISSITGLWASEECSISMPSICKRKKVWVIEKKKDIPKQHGTCP
KGWLYFDYKCLLLKIPEGPSDWKNWTSAQDFCVEEGGTLVAIENEVEQAFITMNLFGHTT
NVWIGLQDDDYEKWLNGRPVSYSNWSPFDTKNIPNHNTTEVQKRIPLCGLLSNNPNFHFT
GKWYFEDCREGYGFVCEKMQDASGHSINTSDMYPIPNTLEYGNRTYKIINANMTWYTALK
TCLMHGAELASITDQYHQSFLTVILNRVGYAHWIGLFTEDNGLSFDWSDGTKSSFTFWKD
DESSFLGDCVFADTSGRWSSTACESYLQGAICQVPTETRLSGRLELCSETSIPWIKFKSN
CYSFSTVLESTSFEAAHEFCKKKGSNLLTIKDEAENSFLLEELLAFRSSVQMIWLNAQFD
GDNETIKWFDGTPTDQSNWGIRKPEVYHFKPHLCVALRIPEGVWQLSSCQDKKGFICKME
ADIHTVKKHPGKGPSHSVIPLTVALTLLVILAISTLSFCMYKHSHIIFGRLAQFRNPYYP
SANFSTVHLEENILISDLEKNDQ
|
| External Links |
|---|
| GenBank ID Protein
| BAA03683.1 |
| UniProtKB/Swiss-Prot ID
| P49259 |
| UniProtKB/Swiss-Prot Entry Name
| PLA2R_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| D16109 |
| GeneCard ID
| PLA2R1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
