Showing Protein Secretory phospholipase A2 receptor (BMDBP00826)
Identification | |
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BMDB Protein ID | BMDBP00826 |
Secondary Accession Numbers | None |
Name | Secretory phospholipase A2 receptor |
Synonyms | Not Available |
Gene Name | PLA2R1 |
Protein Type | Enzyme |
Biological Properties | |
General Function | Involved in receptor activity |
Specific Function | Receptor for secretory phospholipase A2 (sPLA2). Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B and sPLA2-X/PLA2G10. |
Pathways | Not Available |
Reactions | Not Available |
GO Classification | Not Available |
Cellular Location | Not Available |
Gene Properties | |
Chromosome Location | 2 |
Locus | Not Available |
SNPs | PLA2R1 |
Gene Sequence |
>4392 bp ATGCCGCTGCTGTCGCTGTCGCTGCTCCTGCTGCTGCTGCAGGTACCGGCGGGCTCCGCC GAGACCGCGGCGTGGGCAGTCACCCCCGAGCGGCTCCGCGAGTGGCAAGATAAAGGAATC TTCATTATCCAAAGTGAGAACCTCGAGAAATGTATTCAAGCCAGCAAATCTACACTGACC CTGGAGAACTGCAAACCACCCAACAAGTACATGCTGTGGAAGTGGGTTTCAAACCACCGC TTATTTAACATCGGAGGCAGTGGCTGCCTGGGCCTGAACGTGTCTAGTCCAGAGCAGCCA CTGAGCATATACGAGTGTGATTCCACCCACGTTTCCTTGAAGTGGCACTGTAACAAGAAG ACGATCACAGGCCCACTCCAGTACCTGGTCCAGGTGAAGCAGGACAACACGCTTGTGGCC TCAAGGAAATATCTCCATAAGTGGGTTTCCTATATGTCCGGCGGTGGAGGCATTTGTGAC TATCTGCACAAAGATTTGTACACAATCAAAGGGAATGCCCATGGGACTCCGTGCATGTTC CCCTTCCAGTACAATCAGCAGTGGCACCACGAATGTACCCGGGAAGGACGGGAAGACAAC TTGCTGTGGTGTGCCACTACCAGCCGATACGAAAGAGACGAGAAGTGGGGATTTTGCCCA GATCCTACATCCACAGAGGTGGGCTGCGATGCAGTCTGGGAGAAGGATCTCCATTCACGC ATTTGCTACCAATTCAATCTGCTTTCCTCCCTGTCCTGGAGTGAGGCTCATTCTTCATGC CAGATGCAAGGAGCTGCTTTATTAAGTATTGCAGATGAGACTGAAGAAAATTTCGTAAGG AAGCACTTGGGCAGTGAAGCAGTGGAAGTATGGATGGGTCTGAATCAGCTGGATGAAGAT GCTGGTTGGCAGTGGTCTGATAGAACACCACTCAACTATCTGAACTGGAAGCCAGAAATA AATTTTGAGCCATTTGTTGAATATCACTGTGGAACATTTAATGCATTTATGCCAAAGGCC TGGAAAAGTCGGGATTGTGAGTCTACCTTGCCCTACGTGTGTAAAAAATATCTAAATCCC ACTGATCATGGAGTAGTTGAAAAGGATGCTTGGAAATACTATGCTACCCACTGTGAGCCT GGCTGGAATCCCCACAACCGTAATTGCTATAAACTGCAGAAAGAAAAAAAGACCTGGAAT GAGGCTTTGCAGTCTTGCCAGTCCAACAACAGTGTATTAACAGACATCACTTCGTTAGCA GAGGTGGAGTTTCTTGTAACCCTCCTTGGAGATGAAAATGCATCAGAAACATGGATTGGT TTGAGCAGCCATAAAATTCCAGTTTCCTTTGAGTGGTCTAATGGCTCCTCGGTCACCTTT ACTAACTGGCACACACTTGAGCCCCACATTTTTCCAAATAGAAGCCAGTTGTGTGTCTCA GCAGAGCAATCTGAGGGACACTGGAAAGTTAAAAATTGCGAAGAAACACTTTTTTACCTT TGTAAGAAAACAGGCCTTGTCCTTTCTGACACTGAATCAGGCTGTCAAAAGGGATGGGAG AGACATGGTAAATTCTGTTACAAAATTGACACCGTCCTTCGAAGCTTTGACCATGCCTCC AGTGGTTACTACTGTCCTCCTGCGCTTATAACCATTACAAGCAGGTTTGAACAGGCTTTT ATTACCAGTTTGATCAGTAGTGTGGTAAAAACGAAGGACACTTATTTTTGGATCGCTCTT CAAGATCAAAATAATACAGGAGAATACACTTGGAAGACGGCAGGGCAGCAGTTGGAGCCA GTGAAGTACACACACTGGAACACACGTCAGCCCCGCTACAGTGGTGGCTGCGTTGTCATG CGAGGGAGGAGTCACCCTGGCCGCTGGGAAGTGAGGGACTGTAGGCACTTTAAGGCGATG TCCCTGTGCAAGCAACCAGTGGAAAATCGGGAGAAAACCAAGCAAGAAGAGGGATGGCCC TTTCACCCCTGCTATTTGGATTGGGAGTCAGAGCCTGGCCTGGCCAGTTGCTTCAAGGTA TTTCATAGTGAAAAAGTCCTGATGAAAAGAACATGGAGACAAGCTGAAGAATTTTGTGAA GAATTTGGAGCTCATCTTGCAAGCTTTGCCCATATTGAGGAAGAGAATTTTGTGAATGAG CTTTTACATTCAAAATTTAATCGGACAGAAGAAAGGCAGTTCTGGATTGGATTTAATAAA AGAAACCCACTGAATGCTGGTTCTTGGGAATGGTCTGATGGAACTCCTGTTGTCTCTTCA TTTTTAGACAATTCTTATTTTGGAGAAGATGCAAGAAATTGTGCTGTTTATAAGGCAAAT AAAACGTTGCTACCCTCATACTGTGGTTCCAAACGTGAATGGATATGCAAAATTCCAAGA GATGTGAGACCCAAGGTTCCACCCTGGTATCAGTATGATGCACCCTGGCTCTTTTATCAG GATGCAGAGTACCTTTTTCATATTTCTGCCTCAGAATGGTCCTCCTTTGAGTTTGTCTGT GGCTGGCTGCGCAGTGATATTCTCACTATTCATTCTGCACACGAACAAGAATTCATCCAC AGCAAAATAAGAGCGCTATCAAAGTATGGTGTAAATTGGTGGATTGGACTTCGAGAAGAA AGAGCCAGTGATGAATTTCGTTGGAGAGATGGATCACCAGTAATATATCAGAACTGGGAC AAAGGAAAAGAAAGATCTATGGGCCTTAATGAGAGCCAGAGGTGTGGCTTCATTTCATCC ATAACAGGTCTCTGGGCGAGTGAAGAGTGTTCAATTTCTATGCCTAGCATCTGTAAGCGA AAAAAGGTTTGGGTCATAGAAAAAAAGAAAGATATTCCAAAACAACATGGAACATGTCCC AAAGGATGGTTATATTTTGACTATAAGTGCCTTTTGCTGAAAATCCCTGAAGGCCCAAGT GACTGGAAGAACTGGACATCTGCTCAAGATTTTTGTGTTGAAGAAGGGGGGACACTGGTT GCCATTGAAAATGAGGTGGAACAAGCTTTCATTACCATGAATCTTTTTGGCCATACCACT AATGTGTGGATAGGGTTACAAGATGATGATTATGAAAAATGGCTAAATGGAAGGCCTGTG TCATATTCTAATTGGTCTCCATTTGATACAAAAAATATTCCAAATCACAACACCACTGAA GTTCAAAAACGCATTCCTCTCTGTGGCTTGCTGTCAAATAATCCTAATTTTCATTTCACT GGAAAATGGTATTTTGAAGACTGTAGAGAAGGTTATGGGTTTGTTTGTGAAAAAATGCAG GATGCTTCTGGACACAGTATAAATACATCTGATATGTATCCAATCCCTAATACCTTAGAA TATGGAAACAGAACTTACAAAATAATTAATGCAAATATGACTTGGTATACAGCACTAAAA ACCTGCCTGATGCATGGAGCAGAACTGGCCAGCATTACAGACCAGTACCACCAGTCTTTC CTCACTGTTATCCTTAACCGGGTGGGATATGCCCACTGGATTGGACTGTTCACTGAAGAT AATGGTCTTAGTTTTGACTGGTCAGATGGCACCAAATCCTCCTTCACTTTTTGGAAAGAT GATGAATCATCCTTCCTTGGTGACTGTGTTTTTGCTGACACCAGTGGACGCTGGAGTAGC ACAGCCTGCGAGTCGTATCTGCAAGGAGCCATTTGTCAAGTGCCCACTGAAACAAGACTG TCTGGACGCCTAGAGTTGTGCTCAGAAACATCAATTCCCTGGATAAAATTCAAAAGTAAT TGCTACAGTTTTTCTACAGTCCTAGAGAGTACAAGTTTTGAGGCTGCTCATGAATTTTGC AAAAAGAAAGGCTCTAATCTTTTAACAATCAAAGATGAAGCTGAAAACTCTTTTCTTCTA GAAGAGCTTTTAGCTTTCCGTTCTTCAGTCCAGATGATTTGGCTGAATGCTCAGTTTGAT GGTGACAATGAAACCATAAAGTGGTTTGATGGAACTCCCACAGATCAATCAAACTGGGGT ATTCGGAAGCCAGAGGTGTACCACTTCAAACCCCATCTGTGTGTTGCCCTGAGGATTCCT GAAGGAGTGTGGCAATTATCCTCGTGTCAAGACAAAAAGGGATTTATATGTAAAATGGAA GCAGATATTCACACAGTAAAGAAGCATCCAGGAAAAGGACCAAGTCACAGTGTTATACCT CTTACAGTAGCACTGACACTGCTAGTAATTCTGGCAATTTCCACACTTTCCTTCTGCATG TACAAGCACAGTCACATTATCTTCGGGAGACTTGCTCAGTTTAGAAATCCTTACTATCCT TCAGCCAACTTTAGTACAGTACATTTAGAAGAAAATATTCTCATTTCTGATCTTGAGAAG AATGACCAGTAA |
Protein Properties | |
Number of Residues | 1463 |
Molecular Weight | 168651.0 |
Theoretical pI | 6.5 |
Pfam Domain Function | Not Available |
Signals |
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Transmembrane Regions |
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Protein Sequence |
>Secretory phospholipase A2 receptor MPLLSLSLLLLLLQVPAGSAETAAWAVTPERLREWQDKGIFIIQSENLEKCIQASKSTLT LENCKPPNKYMLWKWVSNHRLFNIGGSGCLGLNVSSPEQPLSIYECDSTHVSLKWHCNKK TITGPLQYLVQVKQDNTLVASRKYLHKWVSYMSGGGGICDYLHKDLYTIKGNAHGTPCMF PFQYNQQWHHECTREGREDNLLWCATTSRYERDEKWGFCPDPTSTEVGCDAVWEKDLHSR ICYQFNLLSSLSWSEAHSSCQMQGAALLSIADETEENFVRKHLGSEAVEVWMGLNQLDED AGWQWSDRTPLNYLNWKPEINFEPFVEYHCGTFNAFMPKAWKSRDCESTLPYVCKKYLNP TDHGVVEKDAWKYYATHCEPGWNPHNRNCYKLQKEKKTWNEALQSCQSNNSVLTDITSLA EVEFLVTLLGDENASETWIGLSSHKIPVSFEWSNGSSVTFTNWHTLEPHIFPNRSQLCVS AEQSEGHWKVKNCEETLFYLCKKTGLVLSDTESGCQKGWERHGKFCYKIDTVLRSFDHAS SGYYCPPALITITSRFEQAFITSLISSVVKTKDTYFWIALQDQNNTGEYTWKTAGQQLEP VKYTHWNTRQPRYSGGCVVMRGRSHPGRWEVRDCRHFKAMSLCKQPVENREKTKQEEGWP FHPCYLDWESEPGLASCFKVFHSEKVLMKRTWRQAEEFCEEFGAHLASFAHIEEENFVNE LLHSKFNRTEERQFWIGFNKRNPLNAGSWEWSDGTPVVSSFLDNSYFGEDARNCAVYKAN KTLLPSYCGSKREWICKIPRDVRPKVPPWYQYDAPWLFYQDAEYLFHISASEWSSFEFVC GWLRSDILTIHSAHEQEFIHSKIRALSKYGVNWWIGLREERASDEFRWRDGSPVIYQNWD KGKERSMGLNESQRCGFISSITGLWASEECSISMPSICKRKKVWVIEKKKDIPKQHGTCP KGWLYFDYKCLLLKIPEGPSDWKNWTSAQDFCVEEGGTLVAIENEVEQAFITMNLFGHTT NVWIGLQDDDYEKWLNGRPVSYSNWSPFDTKNIPNHNTTEVQKRIPLCGLLSNNPNFHFT GKWYFEDCREGYGFVCEKMQDASGHSINTSDMYPIPNTLEYGNRTYKIINANMTWYTALK TCLMHGAELASITDQYHQSFLTVILNRVGYAHWIGLFTEDNGLSFDWSDGTKSSFTFWKD DESSFLGDCVFADTSGRWSSTACESYLQGAICQVPTETRLSGRLELCSETSIPWIKFKSN CYSFSTVLESTSFEAAHEFCKKKGSNLLTIKDEAENSFLLEELLAFRSSVQMIWLNAQFD GDNETIKWFDGTPTDQSNWGIRKPEVYHFKPHLCVALRIPEGVWQLSSCQDKKGFICKME ADIHTVKKHPGKGPSHSVIPLTVALTLLVILAISTLSFCMYKHSHIIFGRLAQFRNPYYP SANFSTVHLEENILISDLEKNDQ |
External Links | |
GenBank ID Protein | BAA03683.1 |
UniProtKB/Swiss-Prot ID | P49259 |
UniProtKB/Swiss-Prot Entry Name | PLA2R_BOVIN |
PDB IDs | Not Available |
GenBank Gene ID | D16109 |
GeneCard ID | PLA2R1 |
GenAtlas ID | Not Available |
HGNC ID | Not Available |
References | |
General References | Not Available |