Showing Protein DNA-(apurinic or apyrimidinic site) lyase 2 (BMDBP00828)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00828 |
| Secondary Accession Numbers | None |
| Name | DNA-(apurinic or apyrimidinic site) lyase 2 |
| Synonyms | Not Available |
| Gene Name | APEX2 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Replication, recombination and repair |
| Specific Function | Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | X |
| Locus | Not Available |
| SNPs | APEX2 |
| Gene Sequence |
>1545 bp ATGTTGCGCTTGGTGAGCTGGAACATCAATGGGATACGGAGCCCCTTGCAAGGGGTGAGA TGCGAGGAGCCCAGCAGCTGCAGCGCCATGGCTATGGGGCGCATTTTGGACAAGCTGGAT GCAGACATCGTCTGTCTTCAGGAGACCAAAGTGACCAGGGATGTGCTGACAGAGCCCCTG GCTATCATTGAGGGCTACAACTCCTATTTCAGCTTCAGCCGTAACCGCAGTGGCTATTCT GGTGTAGCCACTTTCTGTAAGGACAGTGCTACCCCAGTGGCTGCTGAAGAAGGCCTGAGT GGCCTGCTTTCCACTCAGAATGGGGATGTGGGTTGCTATGGAAACATGGATGACTTCACC CAAGAGGAACTTCGAGCTCTGGATAGTGAGGGCCGGGCCCTCCTCACACAACACAAAATC TGCACATGGGAAGGGAAGGAGAAGACCTTGACCCTAATCAACGTGTACTGCCCCCATGCG GACCCTGGGAAGCCTGAGCGACTCACCTTTAAGATGCGCTTCTATCGCTTGCTGCAGATC CGAGCAGAAGCTCTCCTGGCAGCTGGCAGCCATGTTATCATTCTGGGTGATCTGAATACA GCCCACCGCCCCATTGATCACTGGGATGCAGTCAACATGGAATGCTTTGAAGAGGACCCA GGGCGCAAGTGGATGGATGGTTTGCTCAGTAACCTGGGGTGTGAGAGTGGCTCCCACATG GGACCCTTCATCGATAGCTACCGCTGCTTCCAGCCAAAGCAGAAGGGGGCCTTCACCTGT TGGTCAACAGTCAGTGGTGCCCGCCATTTGAACTATGGCTCCCGGCTTGACTACGTGTTG GGGGATAGGACCCTGGTCATAGACACCTTTCAGTCTTCCTTCTTGCTGCCTGAGGTGATG GGCTCTGATCACTGCCCTGTGGGTGCAGTCTTAAGCGTGTCCTCTGTGCCAGCAAAACAG TGCCCACCTCTGTGCACCTGCTTCCTCCCTGAGTTTGCAGGTACCCAACTCAAGATCCTA CGATTCCTGGTTCACTTCAAACAAGATCCTGTGTTCAAGCAGTCAGCACTTCAGCCCAGC AATCAAACACAGGTACACATGCGCAAAAACAAAGCCCGTGTGCGCTCAACTAGGTCCCGG CCAAGTAAAACTGGCTCCAGTAGAGGCCAAAAAAACCTGATGAGCTACTTCCAGCCATCC TCCAGTGGCCCCCAAACTTCTAACTTGGATCTTCCTAGCCTGGGCACCCTTATAACCCCA AAGACCTCAGAAGAGGATGTGATGGCCAATGTGGTGGAGGGGCAGACCAAGGCTTCAGAG GCCAAGGATGAAAAGGAGATACGGACCTCATTCTGGAAGTCTCTGCTGGGGGGACCCTCG CCCATGCCCCTCTGTGGGGGACACAGGGAGCCATGTGTAATGCGAACTGTAAAGAAGCCA GGACCCAACCTGGGCCGCCACTTCTACATGTGTGCCAGGCCCCAGGGTCCTCCCACTGAC CCCTCTTCCCGCTGCAATTTCTTCCTCTGGAGCAGGCCCAGCTGA |
| Protein Properties | |
| Number of Residues | 514 |
| Molecular Weight | 56938.0 |
| Theoretical pI | 8.24 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>DNA-(apurinic or apyrimidinic site) lyase 2 MLRLVSWNINGIRSPLQGVRCEEPSSCSAMAMGRILDKLDADIVCLQETKVTRDVLTEPL AIIEGYNSYFSFSRNRSGYSGVATFCKDSATPVAAEEGLSGLLSTQNGDVGCYGNMDDFT QEELRALDSEGRALLTQHKICTWEGKEKTLTLINVYCPHADPGKPERLTFKMRFYRLLQI RAEALLAAGSHVIILGDLNTAHRPIDHWDAVNMECFEEDPGRKWMDGLLSNLGCESGSHM GPFIDSYRCFQPKQKGAFTCWSTVSGARHLNYGSRLDYVLGDRTLVIDTFQSSFLLPEVM GSDHCPVGAVLSVSSVPAKQCPPLCTCFLPEFAGTQLKILRFLVHFKQDPVFKQSALQPS NQTQVHMRKNKARVRSTRSRPSKTGSSRGQKNLMSYFQPSSSGPQTSNLDLPSLGTLITP KTSEEDVMANVVEGQTKASEAKDEKEIRTSFWKSLLGGPSPMPLCGGHREPCVMRTVKKP GPNLGRHFYMCARPQGPPTDPSSRCNFFLWSRPS |
| External Links | |
| GenBank ID Protein | AAX08898.1 |
| UniProtKB/Swiss-Prot ID | Q5E9N9 |
| UniProtKB/Swiss-Prot Entry Name | APEX2_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BT020881 |
| GeneCard ID | APEX2 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |