| Identification |
|---|
| BMDB Protein ID
| BMDBP00833 |
| Secondary Accession Numbers
| None |
| Name
| NAD-dependent protein deacylase sirtuin-5, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| SIRT5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Transcription |
| Specific Function
| NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinylation. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 23 |
| Locus
| Not Available |
| SNPs
| SIRT5 |
| Gene Sequence
|
>933 bp
ATGCCACCTCTCTGGATCATCCGGAACCGATTGTTTTCCCAGCTGTATTGTGGACTGAAG
TCTCCAGTCTCCACACAAACCAAGATTTGCCTAACAATGGCTCGTCCAAGTTCAAATATG
GCTGACTTCCGGAAGTGTTTTGCAAAAGCCAAGCACATAGTCGTCATTTCCGGGGCTGGC
ATCAGTGCTGAGAGTGGGGTTCCAACGTTCAGAGGAGCAGGAGGTTACTGGAGAAAATGG
AAAGCCCAGGACCTGGCCACCCCGCAGGCCTTCGCCCGGAACCCGTCCCAGGTGTGGGAG
TTCTACCACTACCGGCGGGAGGTGGTGCAGAGCACGGAGCCCAACGCCGGGCACCTGGCC
ATCGCCGAGTGCCAGGCCCGGCTGCACAGGCAGGGCCGACAGGTGGTGGTCATCACCCAG
AACATCGACGAGCTGCACCGCAAGGCTGGCACCAAGAACCTTCTGGAAATCCATGGTAGC
TTATTTAAAACTCGATGTACCTCTTGTGGAGTTGTGGCTGAGAACTATAAGAGTCCAATT
TGTCCAGCCTTATCAGGAAAAGGGGCTCCAGACCCCCAAACTCAAGATGCCGGAATCCCA
GTGGAGAAACTGCCCCGGTGTGAAGAGGCAGGATGTGGGGGCCTGCTGCGACCTCACGTG
GTGTGGTTTGGAGAAAACCTGGACCCTGCCATCCTGGAGGAGGTGGACAAAGAGCTGGCC
CTCTGTGACCTGTGTCTAGTGGTGGGGACTTCCTCCGTGGTCTATCCCGCGGCCATGTTT
GCCCCCCAAGTGTCAGCCCGCGGCGTGCCAGTGGCCGAATTCAACATGGAAACCACCCCG
GCCACCGAAAGATTCAGGTTTCATTTCCAGGGGCCGTGTGGGACGACTCTTCCTGAAGCC
CTCGCTCCTCACGAAACTGAAACTGTTTCATAG
|
| Protein Properties |
|---|
| Number of Residues
| 310 |
| Molecular Weight
| 33988.0 |
| Theoretical pI
| 8.17 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>NAD-dependent deacetylase sirtuin-5
MPPLWIIRNRLFSQLYCGLKSPVSTQTKICLTMARPSSNMADFRKCFAKAKHIVVISGAG
ISAESGVPTFRGAGGYWRKWKAQDLATPQAFARNPSQVWEFYHYRREVVQSTEPNAGHLA
IAECQARLHRQGRQVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPI
CPALSGKGAPDPQTQDAGIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDKELA
LCDLCLVVGTSSVVYPAAMFAPQVSARGVPVAEFNMETTPATERFRFHFQGPCGTTLPEA
LAPHETETVS
|
| External Links |
|---|
| GenBank ID Protein
| ACS66701.1 |
| UniProtKB/Swiss-Prot ID
| Q3ZBQ0 |
| UniProtKB/Swiss-Prot Entry Name
| SIR5_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| GQ166651 |
| GeneCard ID
| SIRT5 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
