| Identification |
|---|
| BMDB Protein ID
| BMDBP00834 |
| Secondary Accession Numbers
| None |
| Name
| 5'-3' exonuclease PLD3 |
| Synonyms
|
Not Available
|
| Gene Name
| PLD3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in NAPE-specific phospholipase D activity |
| Specific Function
| 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA) (By similarity). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4 (By similarity). May be important in myotube formation. Plays a role in lysosomal homeostasis. Involved in the regulation of endosomal protein sorting (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| Not Available |
| SNPs
| PLD3 |
| Gene Sequence
|
>1473 bp
ATGAAGCCTAAACTGATGTACCAGGAGCTGAAGGTGCCTGCTGAGGAACCTGCCAGCGAA
CTGCCCATGAATGAGATCGAGGCATGGAAAGCTGCAGAAAAGAAAGCTCGTTGGGTCCTT
CTGGTCCTTATCCTGGCAGTTGTGGGCTTCGGTGCCCTGATGACTCAGCTGTTTCTATGG
GAATACGGCGACTTGCATCTCTTTGGGCCCAATCAGCGCCCAGCCCCCTGCTATGACCCT
TGCGAAGCAGTGCTGGTGGAGAGCATTCCCGAGGGCCTGGACTTCCCCAATGCCTCCACG
AGCAACCCCTCCACCAGCCAGGCCTGGCTGGGCCTGCTCGCTGGTGCCCACAGCAGCCTG
GACATTGCCTCCTTCTACTGGACTCTCACCAACAATGACACCCACACTCAGGAAGCCTCT
GCTCAGCAGGGCGAGGAGGTCCTCCGGCAGCTGCAGACTCTGGCACCCCGAGGTGTGAAG
GTCCGCATTGCTGTGAGCAAGCCCAATGGGCCCCAGCCCCAGGCAGACCTACAGGCGCTG
CTACAGAGCGGTGCCCAGGTCCGCATGGTGGACATGCAGAAGCTGACCCATGGCGTCCTG
CATACCAAGTTCTGGGTGGTGGACCAGACCCACTTCTACCTCGGCAGTGCCAACATGGAT
TGGCGCTCCCTGACCCAGGTCAAGGAGCTGGGTGTGGTCATGTACAACTGCAGCTGCCTA
GCTCGAGACCTGACCAAGATCTTCGAGGCCTACTGGTTCCTGGGCCAGGCGGGCAGCTCC
ATCCCATCAACCTGGCCCCGGCCTTACGACACCCGCTACAATCAAGAGACTCCAATGGAA
ATCTGCCTCAACGGAACCCCTGCTCTGGCCTACCTGGCGAGTGCACCCCCACCGCTGTGT
CCGAGTGGCCGCACCCCAGACTTGAAGGCCCTGCTCAACGTGGTGGACAACGCCCGGAGT
TTCATCTACATCGCAGTCATGAACTACCTGCCCATCATGGAGTTCTCCCACCCACGCCGG
TTCTGGCCTGCCATTGACGACGGGCTGCGGCGGGCTGCCTATGAGCGGGGCGTCAAGGTA
CGCCTGCTGATCAGCTGCTGGGGACACTCTGACCCCTCAATGCGGGCCTTCCTGCTCTCC
CTGGCTGCCCTGCGTGACAACCACACCCACTCCGACATCCAGGTGAAACTCTTTGTGGTC
CCTGCGGACGATGCCCAGGCCCGAATCCCTTATGCCCGCGTCAACCATAACAAGTACATG
GTGACTGAACGGGCCACCTACATCGGAACCTCCAACTGGTCTGGCAGCTACTTCACCGAG
ACGGCAGGCACCTCGCTGCTGGTGACACAGAACGGGCGGGGTGGCCTGCGGAGCCAGCTG
GAGGCCGTGTTCCTGAGGGACTGGGACTCCCCTTATAGCCATGACCTTGACGCTGCCGCC
GACAGCGTGGGCAACGCCTGTCGCCTGCTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 490 |
| Molecular Weight
| 54619.0 |
| Theoretical pI
| 6.64 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Phospholipase D3
MKPKLMYQELKVPAEEPASELPMNEIEAWKAAEKKARWVLLVLILAVVGFGALMTQLFLW
EYGDLHLFGPNQRPAPCYDPCEAVLVESIPEGLDFPNASTSNPSTSQAWLGLLAGAHSSL
DIASFYWTLTNNDTHTQEASAQQGEEVLRQLQTLAPRGVKVRIAVSKPNGPQPQADLQAL
LQSGAQVRMVDMQKLTHGVLHTKFWVVDQTHFYLGSANMDWRSLTQVKELGVVMYNCSCL
ARDLTKIFEAYWFLGQAGSSIPSTWPRPYDTRYNQETPMEICLNGTPALAYLASAPPPLC
PSGRTPDLKALLNVVDNARSFIYIAVMNYLPIMEFSHPRRFWPAIDDGLRRAAYERGVKV
RLLISCWGHSDPSMRAFLLSLAALRDNHTHSDIQVKLFVVPADDAQARIPYARVNHNKYM
VTERATYIGTSNWSGSYFTETAGTSLLVTQNGRGGLRSQLEAVFLRDWDSPYSHDLDAAA
DSVGNACRLL
|
| External Links |
|---|
| GenBank ID Protein
| AAI05310.1 |
| UniProtKB/Swiss-Prot ID
| Q2KJJ8 |
| UniProtKB/Swiss-Prot Entry Name
| PLD3_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC105309 |
| GeneCard ID
| PLD3 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
