Showing Protein 5'-3' exonuclease PLD3 (BMDBP00834)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00834 |
| Secondary Accession Numbers | None |
| Name | 5'-3' exonuclease PLD3 |
| Synonyms | Not Available |
| Gene Name | PLD3 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in NAPE-specific phospholipase D activity |
| Specific Function | 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA) (By similarity). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4 (By similarity). May be important in myotube formation. Plays a role in lysosomal homeostasis. Involved in the regulation of endosomal protein sorting (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 18 |
| Locus | Not Available |
| SNPs | PLD3 |
| Gene Sequence |
>1473 bp ATGAAGCCTAAACTGATGTACCAGGAGCTGAAGGTGCCTGCTGAGGAACCTGCCAGCGAA CTGCCCATGAATGAGATCGAGGCATGGAAAGCTGCAGAAAAGAAAGCTCGTTGGGTCCTT CTGGTCCTTATCCTGGCAGTTGTGGGCTTCGGTGCCCTGATGACTCAGCTGTTTCTATGG GAATACGGCGACTTGCATCTCTTTGGGCCCAATCAGCGCCCAGCCCCCTGCTATGACCCT TGCGAAGCAGTGCTGGTGGAGAGCATTCCCGAGGGCCTGGACTTCCCCAATGCCTCCACG AGCAACCCCTCCACCAGCCAGGCCTGGCTGGGCCTGCTCGCTGGTGCCCACAGCAGCCTG GACATTGCCTCCTTCTACTGGACTCTCACCAACAATGACACCCACACTCAGGAAGCCTCT GCTCAGCAGGGCGAGGAGGTCCTCCGGCAGCTGCAGACTCTGGCACCCCGAGGTGTGAAG GTCCGCATTGCTGTGAGCAAGCCCAATGGGCCCCAGCCCCAGGCAGACCTACAGGCGCTG CTACAGAGCGGTGCCCAGGTCCGCATGGTGGACATGCAGAAGCTGACCCATGGCGTCCTG CATACCAAGTTCTGGGTGGTGGACCAGACCCACTTCTACCTCGGCAGTGCCAACATGGAT TGGCGCTCCCTGACCCAGGTCAAGGAGCTGGGTGTGGTCATGTACAACTGCAGCTGCCTA GCTCGAGACCTGACCAAGATCTTCGAGGCCTACTGGTTCCTGGGCCAGGCGGGCAGCTCC ATCCCATCAACCTGGCCCCGGCCTTACGACACCCGCTACAATCAAGAGACTCCAATGGAA ATCTGCCTCAACGGAACCCCTGCTCTGGCCTACCTGGCGAGTGCACCCCCACCGCTGTGT CCGAGTGGCCGCACCCCAGACTTGAAGGCCCTGCTCAACGTGGTGGACAACGCCCGGAGT TTCATCTACATCGCAGTCATGAACTACCTGCCCATCATGGAGTTCTCCCACCCACGCCGG TTCTGGCCTGCCATTGACGACGGGCTGCGGCGGGCTGCCTATGAGCGGGGCGTCAAGGTA CGCCTGCTGATCAGCTGCTGGGGACACTCTGACCCCTCAATGCGGGCCTTCCTGCTCTCC CTGGCTGCCCTGCGTGACAACCACACCCACTCCGACATCCAGGTGAAACTCTTTGTGGTC CCTGCGGACGATGCCCAGGCCCGAATCCCTTATGCCCGCGTCAACCATAACAAGTACATG GTGACTGAACGGGCCACCTACATCGGAACCTCCAACTGGTCTGGCAGCTACTTCACCGAG ACGGCAGGCACCTCGCTGCTGGTGACACAGAACGGGCGGGGTGGCCTGCGGAGCCAGCTG GAGGCCGTGTTCCTGAGGGACTGGGACTCCCCTTATAGCCATGACCTTGACGCTGCCGCC GACAGCGTGGGCAACGCCTGTCGCCTGCTCTGA |
| Protein Properties | |
| Number of Residues | 490 |
| Molecular Weight | 54619.0 |
| Theoretical pI | 6.64 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions |
|
| Protein Sequence |
>Phospholipase D3 MKPKLMYQELKVPAEEPASELPMNEIEAWKAAEKKARWVLLVLILAVVGFGALMTQLFLW EYGDLHLFGPNQRPAPCYDPCEAVLVESIPEGLDFPNASTSNPSTSQAWLGLLAGAHSSL DIASFYWTLTNNDTHTQEASAQQGEEVLRQLQTLAPRGVKVRIAVSKPNGPQPQADLQAL LQSGAQVRMVDMQKLTHGVLHTKFWVVDQTHFYLGSANMDWRSLTQVKELGVVMYNCSCL ARDLTKIFEAYWFLGQAGSSIPSTWPRPYDTRYNQETPMEICLNGTPALAYLASAPPPLC PSGRTPDLKALLNVVDNARSFIYIAVMNYLPIMEFSHPRRFWPAIDDGLRRAAYERGVKV RLLISCWGHSDPSMRAFLLSLAALRDNHTHSDIQVKLFVVPADDAQARIPYARVNHNKYM VTERATYIGTSNWSGSYFTETAGTSLLVTQNGRGGLRSQLEAVFLRDWDSPYSHDLDAAA DSVGNACRLL |
| External Links | |
| GenBank ID Protein | AAI05310.1 |
| UniProtKB/Swiss-Prot ID | Q2KJJ8 |
| UniProtKB/Swiss-Prot Entry Name | PLD3_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC105309 |
| GeneCard ID | PLD3 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |