Showing Protein Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (BMDBP00843)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00843 |
| Secondary Accession Numbers | None |
| Name | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 |
| Synonyms | Not Available |
| Gene Name | RPN2 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in dolichyl-diphosphooligosaccharide-protein g |
| Specific Function | Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. |
| Pathways |
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| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 13 |
| Locus | Not Available |
| SNPs | RPN2 |
| Gene Sequence |
>1896 bp ATGGCGCTGCCGGGTTCAAGCACTGTCTTCCTGTTGGCCCTGACAATCATAGCCAGCACC CAGGCTTTGACGCCTACTCACTACCTCACCAAGCATGACGTGGAGAGACTGAAAGCCTCT CTGGACCGCCCTTTCACAAGTTTGGAGTCTGCTTTCTACTCCATCGTGGGACTCAGCAGC CTTGGTGCCCAGGTGCCAGATGTAAAGAAAGCGTGCACCTTCATTAAATCAAACCTTGAT CCCAGCAACGTGGATTCCCTTTTCTACGCCGCTCAGTCCAGCCAGGCCCTCTCAGGGTGT GAGATCTCTATTTCAAATGAGACCAAAGACCTGCTACTGGCAGCTGTGAGCGAAGACTCT TCGGTGGCCCAGATCTACCATGCAGTGGCAGCCCTCAGTGGCTTTGGCCTCCCCTTGGCT TCCCAGGAAGCGCTCGGTGCCCTTACTGCCCGTCTCAGCAAGGAGGAGACCGTGCTAGCA ACAGTCCAGGCTCTACAGACGGCCTCCTACCTGTCCCAGCAGGCTGACCTGAGAAGCATC GTGGAGGAGATTGAGGACCTTGTTGCTCGCCTGGATGAACTGGGAGGTGTGTATCTCCAG TTTGAAGAAGGACTGGAAACGACGGCATTGTTTGTGGCTGCCACCTACAAGCTTATGGAC CATGTGGGGACGGAGCCATCCATTAAGGAGGATCAGGTCATCCAGCTCATGAACGCCATC TTCAGCAAGAAGAACTTTGAGTCACTCTCTGAAGCCTTCAGTGTGGCCTCTGCTGCCGCT GCGCTCTCTGAGAATCGCTACCATGTGCCCGTTGTGGTTGTGCCCGAGGGCTCTCCTTCC TACACTCAGGAACAGGCTATCCTGCGGTTGCAGGTCACCAACGTTCTGTCCCAGCCTTTG ACTCAGGCTACTGTTAAACTAGAACATGCGAAATCTGTTGCTTCCAGAGCTACAGTCCTT CAGAAGACATCATTCACCCTCATCGGGGATGTTTTTGAGCTAAACTTCATGAATGTCAAA TTTTCCAGTGGTTATTATGACTTCTCTGTCAAAGTTGAAGGTGACAACCGTTACATTGCA AATACTGTAGAGCTCAGAGTCAAGATTTCCACTGAAGTTGGCATCACAAATGTCGATCTC TCCACTGTGGATAAGGATCAGAGCATCGCCCCCAAAACAACACGGGTGACCTACCCAGCC AAAGCCAAGGGCACATTCATTGCGGACAGCCACCAGAACTTTGCCTTATTCTTCCAGCTG GTAGATGTGAACACTGGCGCTGAACTCACCCCTCACCAGACATTTGTCCGACTCCACAAC CAGAAGACTGGCCAGGAAGTGGTGTTTGTTGCAGAGCCGGACAGCAAGAATGTGTACAAG TTTGAACTGGACACCTCCGAGAGAAAGCTCGAATTTGACTCTGCATCTGGCACCTACACA CTCTACTTGATCATCGGAGATGCAACTTTGAAGAACCCAATCCTGTGGAATGTGGCTGAT GTGGTCATCAGGTTCCCTGAAGATGATGTTCCGTCAACTGTCCTGTCCAAGAACATTTTC ACCCCCAAACAGGAAATTCAGCACCTGTTCCGCGAGCCTGAGAAGAGGCCCCCCACAGTG GTGTCCAATACATTCACCGCGCTGATCCTCTCGCCCCTGCTCCTGCTCTTTGCTCTGTGG ATCCGGATTGGTGCCAATGTCTCCAACTTCACTTTTGCTCCCAGCACAATTGTCTTTCAC CTGGGACATGCTGCTATGCTGGGGCTCATGTATGTCTACTGGACACAACTCAACATGTTC CAGACCCTGAAGTACCTGGCCATCTTAGGCAGCGTGACGTTTCTGGCTGGCAATCGGATG CTGGCTCAGCAGGCAATCAAGAGAACAGCACATTAG |
| Protein Properties | |
| Number of Residues | 631 |
| Molecular Weight | 69214.0 |
| Theoretical pI | 5.49 |
| Pfam Domain Function | Not Available |
| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 MALPGSSTVFLLALTIIASTQALTPTHYLTKHDVERLKASLDRPFTSLESAFYSIVGLSS LGAQVPDVKKACTFIKSNLDPSNVDSLFYAAQSSQALSGCEISISNETKDLLLAAVSEDS SVAQIYHAVAALSGFGLPLASQEALGALTARLSKEETVLATVQALQTASYLSQQADLRSI VEEIEDLVARLDELGGVYLQFEEGLETTALFVAATYKLMDHVGTEPSIKEDQVIQLMNAI FSKKNFESLSEAFSVASAAAALSENRYHVPVVVVPEGSPSYTQEQAILRLQVTNVLSQPL TQATVKLEHAKSVASRATVLQKTSFTLIGDVFELNFMNVKFSSGYYDFSVKVEGDNRYIA NTVELRVKISTEVGITNVDLSTVDKDQSIAPKTTRVTYPAKAKGTFIADSHQNFALFFQL VDVNTGAELTPHQTFVRLHNQKTGQEVVFVAEPDSKNVYKFELDTSERKLEFDSASGTYT LYLIIGDATLKNPILWNVADVVIRFPEDDVPSTVLSKNIFTPKQEIQHLFREPEKRPPTV VSNTFTALILSPLLLLFALWIRIGANVSNFTFAPSTIVFHLGHAAMLGLMYVYWTQLNMF QTLKYLAILGSVTFLAGNRMLAQQAIKRTAH |
| External Links | |
| GenBank ID Protein | ABQ12953.1 |
| UniProtKB/Swiss-Prot ID | Q3SZI6 |
| UniProtKB/Swiss-Prot Entry Name | RPN2_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BT030513 |
| GeneCard ID | RPN2 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |