Showing Protein Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (BMDBP00844)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00844 |
| Secondary Accession Numbers | None |
| Name | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A |
| Synonyms | Not Available |
| Gene Name | STT3A |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in dolichyl-diphosphooligosaccharide-protein g |
| Specific Function | Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (By similarity). STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient post-translational glycosylation and mediate glycosylation of sites that have been skipped by STT3A (By similarity). |
| Pathways |
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| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 29 |
| Locus | Not Available |
| SNPs | STT3A |
| Gene Sequence |
>2118 bp ATGACCAAGCTGGGATTTTTGCGGTTGTCCTATGAGAAGCAGGACACACTTCTGAAGCTT CTGATTCTGTCGATGGCTGCTGTGTTATCATTCTCCACTCGTCTCTTTGCTGTCTTGAGA TTTGAAAGTGTCATCCATGAATTTGATCCGTACTTTAATTATCGCACCACCCGGTTCCTG GCTGAGGAGGGATTTTATAAATTCCATAACTGGTTTGATGACCGGGCCTGGTACCCCTTG GGACGAATCATTGGAGGAACAATTTACCCAGGCTTAATGATCACTTCTGCTGCAATCTAC CATGTCCTCCATTTTTTCCACATCACCATCGACATTCGGAATGTCTGTGTGTTCCTGGCC CCTCTCTTCTCTTCCTTCACTACCATCGTCACGTACCACCTTACCAAAGAGCTCAAGGAT GCAGGAGCTGGGCTTCTTGCTGCCGCCATGATTGCTGTGGTTCCTGGCTATATCTCCCGG TCTGTGGCTGGCTCCTATGATAATGAAGGGATTGCCATCTTTTGCATGCTGCTTACCTAT TACATGTGGATCAAAGCAGTCAAGACTGGTTCCATCTACTGGGCAGCAAAGTGTGCCCTT GCTTACTTCTACATGGTCTCTTCCTGGGGAGGTTATGTGTTCTTGATCAACTTGATCCCT CTTCATGTACTAGTGCTGATGCTCACGGGACGTTTCTCGCACCGGATCTACGTGGCGTAC TGTACTGTCTACTGCCTGGGCACCATTCTTTCCATGCAGATCTCCTTTGTGGGTTTCCAG CCCGTCCTTTCATCAGAGCACATGGCAGCCTTTGGGGTGTTTGGTCTCTGCCAGATTCAT GCCTTTGTGGATTATCTACGCAGCAAGTTGAATCCACAGCAATTTGAAGTTCTTTTCCGA AGTGTCATCTCCCTAGTGGGCTTTGTCCTTCTCACCATTGGAGCTCTCCTCATGCTGACA GGAAAAATATCTCCCTGGACGGGGCGTTTCTACTCACTGTTGGACCCTTCCTATGCTAAG AACAACATCCCCATCATCGCCTCCGTGTCTGAGCATCAGCCTACGACCTGGTCCTCGTAC TATTTCGACCTACAGCTTCTTGTCTTCATGTTTCCAGTTGGTCTCTATTACTGCTTTAGC AACCTGTCTGATGCCCGGATTTTCATCATCATGTATGGTGTGACCAGCATGTACTTTTCA GCTGTAATGGTGCGTCTGATGCTGGTGTTGGCGCCTGTTATGTGCATTCTTTCTGGCATT GGAGTCTCTCAGGTGCTGTCCACTTACATGAAGAATTTGGACATAAGTCGACAAGACAAG AAGAGCAAGAAACAGCAGGATTCTACTTACCCTATTAAGAATGAAGTGGCAAGTGGCATG ATACTGGTCATGGCTTTCTTTCTCATTACCTACACCTTCCACTCGACCTGGGTGACCAGT GAGGCCTACTCTTCTCCCTCCATTGTGCTGTCTGCTCGTGGTGGAGATGGCAGTAGGATC ATTTTTGATGATTTTCGAGAAGCGTACTATTGGCTTCGTCACAATACTCCAGAGGATGCG AAGGTCATGTCATGGTGGGATTATGGCTACCAGATTACAGCTATGGCGAATCGGACAATT TTAGTGGATAATAACACGTGGAATAATACCCATATATCTCGAGTAGGGCAGGCAATGGCA TCCACAGAAGAAAAAGCCTATGAGATCATGAGGGAGCTTGATGTCAGCTATGTGCTGGTC ATTTTTGGAGGCCTCACTGGGTATTCTTCAGATGACATCAACAAATTTCTGTGGATGGTC CGGATTGGAGGGAGCACAGATACAGGGAAACACATCAAGGAGCACGATTATTATACTCCA ACTGGGGAGTTTCGTGTGGACCGTGAGGGCTCTCCAGTGCTGCTCAACTGCCTTATGTAC AAGATGTGTTACTACCGATTTGGACAGGTTTACACAGAAGCCAAGCGTCCACTAGGCTAT GACCGTGTCCGGAATGCTGAGATTGGGAATAAAGACTTCGAGCTTGATGTCCTAGAAGAA GCATACACCACAGAACATTGGCTGGTCAGGATATACAAGGTGAAGGACCTGGATAATCGA GGCTTGTCAAGAACATAA |
| Protein Properties | |
| Number of Residues | 705 |
| Molecular Weight | 80656.0 |
| Theoretical pI | 8.21 |
| Pfam Domain Function | Not Available |
| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A MTKLGFLRLSYEKQDTLLKLLILSMAAVLSFSTRLFAVLRFESVIHEFDPYFNYRTTRFL AEEGFYKFHNWFDDRAWYPLGRIIGGTIYPGLMITSAAIYHVLHFFHITIDIRNVCVFLA PLFSSFTTIVTYHLTKELKDAGAGLLAAAMIAVVPGYISRSVAGSYDNEGIAIFCMLLTY YMWIKAVKTGSIYWAAKCALAYFYMVSSWGGYVFLINLIPLHVLVLMLTGRFSHRIYVAY CTVYCLGTILSMQISFVGFQPVLSSEHMAAFGVFGLCQIHAFVDYLRSKLNPQQFEVLFR SVISLVGFVLLTIGALLMLTGKISPWTGRFYSLLDPSYAKNNIPIIASVSEHQPTTWSSY YFDLQLLVFMFPVGLYYCFSNLSDARIFIIMYGVTSMYFSAVMVRLMLVLAPVMCILSGI GVSQVLSTYMKNLDISRQDKKSKKQQDSTYPIKNEVASGMILVMAFFLITYTFHSTWVTS EAYSSPSIVLSARGGDGSRIIFDDFREAYYWLRHNTPEDAKVMSWWDYGYQITAMANRTI LVDNNTWNNTHISRVGQAMASTEEKAYEIMRELDVSYVLVIFGGLTGYSSDDINKFLWMV RIGGSTDTGKHIKEHDYYTPTGEFRVDREGSPVLLNCLMYKMCYYRFGQVYTEAKRPLGY DRVRNAEIGNKDFELDVLEEAYTTEHWLVRIYKVKDLDNRGLSRT |
| External Links | |
| GenBank ID Protein | AAI05329.1 |
| UniProtKB/Swiss-Prot ID | Q2KJI2 |
| UniProtKB/Swiss-Prot Entry Name | STT3A_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC105328 |
| GeneCard ID | STT3A |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |