| Identification |
|---|
| BMDB Protein ID
| BMDBP00845 |
| Secondary Accession Numbers
| None |
| Name
| Exostosin-2 |
| Synonyms
|
Not Available
|
| Gene Name
| EXT2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in glucuronosyl-N-acetylglucosaminyl-proteogly |
| Specific Function
| Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan. |
| Pathways
|
- Protein glycosylation
- Protein modification
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 15 |
| Locus
| Not Available |
| SNPs
| EXT2 |
| Gene Sequence
|
>2157 bp
ATGTGCGCGTCGGTCAAGTACAACATCCGGGGTCCCGCCCTCATCCCGAGAATGAAGACC
AAGCACCGCATCTACTACATCACCCTCTTCTCCATCGTCCTGCTGGGTCTGATCGCCACG
GGCATGTTTCAGTTCTGGCCGCACTCCATCGAGTCCTCCGGCGACTGGAGCGTGGAGAAG
CGCACTGGCCGAGACGTGCCGCTGGTCAGGCTGCCGGCCGACAGCCCGGTGCCAGAGCGC
GGCGACCTCAGCTGCAGGATGCACACGTGTTTCGACGTCTACCGCTGCGGCTTCAACCCC
AAGAACAAGATCAAGGTGTACATCTACCCGCTGAAGAAGTACGTGGGCGAGGCGGGTGTC
CCGGTGAGCAGCACCATCTCCCGGGAGTACAACGAGCTGCTCACGGCCATCTCAGACAGC
GACTACTACACCGACGACGTCACCCGCGCCTGCCTGTTCGTCCCGTCCATCGACCTGCTC
AACCAGAACTCGCTCCGCGTGAAGGAGACGGCGCAGGCGCTGGCCCAGCTCTCCAGGTGG
GATAGAGGTACCAATCACCTCCTGTTCAACATGTTGCCTGGAGGCCCTCCAGATTATAAC
ACGGCCCTGGATGTCCCCAGAGACAGGGCTCTGTTGGCTGGTGGTGGCTTCTCTACGTGG
ACTTATCGGCAAGGCTACGATGTCAGCATTCCTGTCTATAGTCCGCTGTCAGCCGAGGTG
GACCTTCCGGAGAAGGGGCCCGGGCCGCGGCGGTACTTCCTGCTGTCGTCCCAGGTGGCC
CTGCATCCAGAGTACAGAGAGGACCTGGCCGCCCTCCAGGCCAGACACGGCGAGGCGGTG
CTGGTGCTGGACAAGTGCAGCAACCTCTCCGAGGGCGTCCCCGCCGCCCGGAGGCGCTGC
CACCAGCAGCAGGCCTTTGACTACCCGCAGGTGCTGCAGGAGGCTACTTTCTGCATGGTC
CTTCGTGGAGCTCGGCTGGGCCAGGCGGTACTGAGTGATGTGTTACGGGCCGGCTGCGTC
CCAGTGATCATCGCAGACTCCTACGTTTTGCCTTTCTCTGAAGTCCTTGACTGGAAGAGA
GCATCTGTAGTTGTGCCAGAAGAAAAGATGTCAGATGTCTACAGTATTCTGCAGAGCATC
CCCCGAAGACAGATTGAAGAAATGCAGAGACAGGCACGGTGGTTTTGGGAAGCATACTTC
CAGTCAATCAAGGCCATCGCCCTGGCCACCCTGCAGATCATCAATGATCGGATCTATCCA
TACGCTGCCATCTCCTATGAAGACTGGAACGACCCTCCTGCTGTGAAGTGGGGCAGTGTG
AGCAACCCTCTCTTCCTTCCCCTCATCCCCCCACAATCTCAAGGTTTCACGGCCATCGTC
CTCACCTACGACCGAGTGGAGAGCCTCTTCCGGGTCATCACCGAAGTGTCCAAGGTGCCC
AGCCTATCCAAGCTGCTGGTCGTCTGGAACAATCAGAATAAAAACCCTCCTGAAGATTCT
CTGTGGCCCAAAATCCGGGTTCCATTAAAAGTTGTGAGAACAGCTGAAAACAAGTTGAGT
AACCGCTTCTTCCCTTACGATGAAATCGAGACAGAGGCCGTCCTGGCTATTGATGATGAT
ATCATCATGCTGACCTCTGATGAACTGCAGTTCGGTTATGAGGTCTGGCGAGAATTTCCT
GACCGGTTGGTGGGTTACCCGGGTCGCCTGCATCTCTGGGACCATGAGATGAATAAGTGG
AAGTATGAGTCTGAGTGGACCAATGAGGTGTCCATGGTGCTCACGGGGGCAGCCTTTTAC
CACAAGTATTTTAATTACCTGTATACCTACAAGATGCCTGGGGACATCAAGAACTGGGTG
GATGCTCATATGAACTGTGAAGACATTGCCATGAATTTCCTGGTGGCTAACGTCACAGGG
AAAGCTGTCATCAAGGTAACACCACGAAAGAAATTCAAGTGTCCTGAATGCACAGCCATT
GATGGGCTTTCGCTCGACCAGACGCACATGGTGGAGAGGTCCGAGTGCATCAACAAGTTT
GCTTCCGTCTTTGGGACAATGCCTCTTAAGGTGGTGGAGCACCGAGCCGACCCTGTCCTA
TACAAGGACGACTTCCCTGAGAAACTGAAGAGCTTCCCCAACATCGGCAGCTTATGA
|
| Protein Properties |
|---|
| Number of Residues
| 718 |
| Molecular Weight
| 81887.0 |
| Theoretical pI
| 6.96 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Exostosin-2
MCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQFWPHSIESSGDWSVEK
RTGRDVPLVRLPADSPVPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYPLKKYVGEAGV
PVSSTISREYNELLTAISDSDYYTDDVTRACLFVPSIDLLNQNSLRVKETAQALAQLSRW
DRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIPVYSPLSAEV
DLPEKGPGPRRYFLLSSQVALHPEYREDLAALQARHGEAVLVLDKCSNLSEGVPAARRRC
HQQQAFDYPQVLQEATFCMVLRGARLGQAVLSDVLRAGCVPVIIADSYVLPFSEVLDWKR
ASVVVPEEKMSDVYSILQSIPRRQIEEMQRQARWFWEAYFQSIKAIALATLQIINDRIYP
YAAISYEDWNDPPAVKWGSVSNPLFLPLIPPQSQGFTAIVLTYDRVESLFRVITEVSKVP
SLSKLLVVWNNQNKNPPEDSLWPKIRVPLKVVRTAENKLSNRFFPYDEIETEAVLAIDDD
IIMLTSDELQFGYEVWREFPDRLVGYPGRLHLWDHEMNKWKYESEWTNEVSMVLTGAAFY
HKYFNYLYTYKMPGDIKNWVDAHMNCEDIAMNFLVANVTGKAVIKVTPRKKFKCPECTAI
DGLSLDQTHMVERSECINKFASVFGTMPLKVVEHRADPVLYKDDFPEKLKSFPNIGSL
|
| External Links |
|---|
| GenBank ID Protein
| AAC35386.1 |
| UniProtKB/Swiss-Prot ID
| O77783 |
| UniProtKB/Swiss-Prot Entry Name
| EXT2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF089748 |
| GeneCard ID
| EXT2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
