Showing Protein Exostosin-2 (BMDBP00845)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00845 |
| Secondary Accession Numbers | None |
| Name | Exostosin-2 |
| Synonyms | Not Available |
| Gene Name | EXT2 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in glucuronosyl-N-acetylglucosaminyl-proteogly |
| Specific Function | Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan. |
| Pathways |
|
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 15 |
| Locus | Not Available |
| SNPs | EXT2 |
| Gene Sequence |
>2157 bp ATGTGCGCGTCGGTCAAGTACAACATCCGGGGTCCCGCCCTCATCCCGAGAATGAAGACC AAGCACCGCATCTACTACATCACCCTCTTCTCCATCGTCCTGCTGGGTCTGATCGCCACG GGCATGTTTCAGTTCTGGCCGCACTCCATCGAGTCCTCCGGCGACTGGAGCGTGGAGAAG CGCACTGGCCGAGACGTGCCGCTGGTCAGGCTGCCGGCCGACAGCCCGGTGCCAGAGCGC GGCGACCTCAGCTGCAGGATGCACACGTGTTTCGACGTCTACCGCTGCGGCTTCAACCCC AAGAACAAGATCAAGGTGTACATCTACCCGCTGAAGAAGTACGTGGGCGAGGCGGGTGTC CCGGTGAGCAGCACCATCTCCCGGGAGTACAACGAGCTGCTCACGGCCATCTCAGACAGC GACTACTACACCGACGACGTCACCCGCGCCTGCCTGTTCGTCCCGTCCATCGACCTGCTC AACCAGAACTCGCTCCGCGTGAAGGAGACGGCGCAGGCGCTGGCCCAGCTCTCCAGGTGG GATAGAGGTACCAATCACCTCCTGTTCAACATGTTGCCTGGAGGCCCTCCAGATTATAAC ACGGCCCTGGATGTCCCCAGAGACAGGGCTCTGTTGGCTGGTGGTGGCTTCTCTACGTGG ACTTATCGGCAAGGCTACGATGTCAGCATTCCTGTCTATAGTCCGCTGTCAGCCGAGGTG GACCTTCCGGAGAAGGGGCCCGGGCCGCGGCGGTACTTCCTGCTGTCGTCCCAGGTGGCC CTGCATCCAGAGTACAGAGAGGACCTGGCCGCCCTCCAGGCCAGACACGGCGAGGCGGTG CTGGTGCTGGACAAGTGCAGCAACCTCTCCGAGGGCGTCCCCGCCGCCCGGAGGCGCTGC CACCAGCAGCAGGCCTTTGACTACCCGCAGGTGCTGCAGGAGGCTACTTTCTGCATGGTC CTTCGTGGAGCTCGGCTGGGCCAGGCGGTACTGAGTGATGTGTTACGGGCCGGCTGCGTC CCAGTGATCATCGCAGACTCCTACGTTTTGCCTTTCTCTGAAGTCCTTGACTGGAAGAGA GCATCTGTAGTTGTGCCAGAAGAAAAGATGTCAGATGTCTACAGTATTCTGCAGAGCATC CCCCGAAGACAGATTGAAGAAATGCAGAGACAGGCACGGTGGTTTTGGGAAGCATACTTC CAGTCAATCAAGGCCATCGCCCTGGCCACCCTGCAGATCATCAATGATCGGATCTATCCA TACGCTGCCATCTCCTATGAAGACTGGAACGACCCTCCTGCTGTGAAGTGGGGCAGTGTG AGCAACCCTCTCTTCCTTCCCCTCATCCCCCCACAATCTCAAGGTTTCACGGCCATCGTC CTCACCTACGACCGAGTGGAGAGCCTCTTCCGGGTCATCACCGAAGTGTCCAAGGTGCCC AGCCTATCCAAGCTGCTGGTCGTCTGGAACAATCAGAATAAAAACCCTCCTGAAGATTCT CTGTGGCCCAAAATCCGGGTTCCATTAAAAGTTGTGAGAACAGCTGAAAACAAGTTGAGT AACCGCTTCTTCCCTTACGATGAAATCGAGACAGAGGCCGTCCTGGCTATTGATGATGAT ATCATCATGCTGACCTCTGATGAACTGCAGTTCGGTTATGAGGTCTGGCGAGAATTTCCT GACCGGTTGGTGGGTTACCCGGGTCGCCTGCATCTCTGGGACCATGAGATGAATAAGTGG AAGTATGAGTCTGAGTGGACCAATGAGGTGTCCATGGTGCTCACGGGGGCAGCCTTTTAC CACAAGTATTTTAATTACCTGTATACCTACAAGATGCCTGGGGACATCAAGAACTGGGTG GATGCTCATATGAACTGTGAAGACATTGCCATGAATTTCCTGGTGGCTAACGTCACAGGG AAAGCTGTCATCAAGGTAACACCACGAAAGAAATTCAAGTGTCCTGAATGCACAGCCATT GATGGGCTTTCGCTCGACCAGACGCACATGGTGGAGAGGTCCGAGTGCATCAACAAGTTT GCTTCCGTCTTTGGGACAATGCCTCTTAAGGTGGTGGAGCACCGAGCCGACCCTGTCCTA TACAAGGACGACTTCCCTGAGAAACTGAAGAGCTTCCCCAACATCGGCAGCTTATGA |
| Protein Properties | |
| Number of Residues | 718 |
| Molecular Weight | 81887.0 |
| Theoretical pI | 6.96 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions |
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| Protein Sequence |
>Exostosin-2 MCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQFWPHSIESSGDWSVEK RTGRDVPLVRLPADSPVPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYPLKKYVGEAGV PVSSTISREYNELLTAISDSDYYTDDVTRACLFVPSIDLLNQNSLRVKETAQALAQLSRW DRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIPVYSPLSAEV DLPEKGPGPRRYFLLSSQVALHPEYREDLAALQARHGEAVLVLDKCSNLSEGVPAARRRC HQQQAFDYPQVLQEATFCMVLRGARLGQAVLSDVLRAGCVPVIIADSYVLPFSEVLDWKR ASVVVPEEKMSDVYSILQSIPRRQIEEMQRQARWFWEAYFQSIKAIALATLQIINDRIYP YAAISYEDWNDPPAVKWGSVSNPLFLPLIPPQSQGFTAIVLTYDRVESLFRVITEVSKVP SLSKLLVVWNNQNKNPPEDSLWPKIRVPLKVVRTAENKLSNRFFPYDEIETEAVLAIDDD IIMLTSDELQFGYEVWREFPDRLVGYPGRLHLWDHEMNKWKYESEWTNEVSMVLTGAAFY HKYFNYLYTYKMPGDIKNWVDAHMNCEDIAMNFLVANVTGKAVIKVTPRKKFKCPECTAI DGLSLDQTHMVERSECINKFASVFGTMPLKVVEHRADPVLYKDDFPEKLKSFPNIGSL |
| External Links | |
| GenBank ID Protein | AAC35386.1 |
| UniProtKB/Swiss-Prot ID | O77783 |
| UniProtKB/Swiss-Prot Entry Name | EXT2_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | AF089748 |
| GeneCard ID | EXT2 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |