| Identification |
|---|
| BMDB Protein ID
| BMDBP00846 |
| Secondary Accession Numbers
| None |
| Name
| Hyaluronan synthase 2 |
| Synonyms
|
Not Available
|
| Gene Name
| HAS2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Cell wall/membrane/envelope biogenesis |
| Specific Function
| Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix (By similarity). |
| Pathways
|
- Glycan biosynthesis
- Hyaluronan biosynthesis
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 14 |
| Locus
| Not Available |
| SNPs
| HAS2 |
| Gene Sequence
|
>1659 bp
ATGCATTGTGAGAGATTTCTATGTATCCTGAGAATAATTGGAACCACACTTTTTGGAGTC
TCTCTCCTCCTTGGAATCACAGCTGCTTATATTGTTGGCTATCAATTTATCCAAACAGAT
AATTACTATTTCTCTTTTGGACTGTATGGTGCCTTTTTAGCATCACACCTCATCATCCAA
AGCCTGTTTGCCTTTTTGGAGCACCGGAAAATGAAAAAATCTCTAGAAACCCCCATTAAG
TTGAACAAAACTGTTGCTCTTTGCATTGCTGCATATCAAGAAGATCCAGACTATTTGCGG
AAATGTTTGCAATCTGTGAAAAGGCTAACCTACCCCGGAATTAAAGTTGTCATGGTCATA
GATGGAAACTCGGAAGATGACCTTTACATGATGGACATCTTCAGTGAAGTCATGGGCAGG
GACAAGTCAGCCACTTATATCTGGAAGAACAACTACCATGTGAAGGGTCCTGGAGAGACG
GATGAGTCGCACAAAGAAAGCTCACAGCATGTCACCCAGTTGGTCTTGTCCAACAAGAGT
ATTTGCACCATGCAAAAATGGGGTGGAAAAAGAGAAGTCATGTACACAGCCTTCAGAGCA
CTGGGGCGAAGTGTGGATTATGTACAGGTTTGTGATTCAGACACCATGCTTGACCCAGCA
TCATCTGTGGAGATGGTAAAAGTTTTAGAAGAAGATCCCATGGTTGGAGGTGTCGGGGGA
GATGTCCAGATTTTAAACAAGTATGATTCCTGGATCTCCTTCCTCAGCAGTGTGAGATAC
TGGATGGCTTTTAACATAGAAAGGGCCTGTCAGTCTTATTTCGGATGTGTCCAGTGCATT
AGCGGACCTCTGGGAATGTACAGAAACTCCTTACTGCATGAATTTGTGGAAGACTGGTAC
AATCAAGAATTTATGGGCAGCCAATGTAGTTTTGGAGATGACAGGCATCTAACGAACCGA
GTGCTGAGTCTGGGCTATGCAACGAAATACACAGCTCGATCCAAGTGCCTTACTGAAACA
CCTATAGAATATCTCAGATGGTTAAACCAGCAGACCCGCTGGAGCAAGTCGTACTTCCGA
GAGTGGCTGTACAACGCTATGTGGTTTCATAAACATCACTTGTGGATGACCTATGAAGCC
GTCATCACTGGGTTCTTCCCTTTCTTTCTCATTGCCACGGTAATCCAGCTCTTCTACAGG
GGTAAAATTTGGAACACCCTCCTCTTCTTGTTAACTGTCCAGTTAGTGGGTCTCATAAAA
TCATCTTTTGCCAGCTGCCTTAGAGGAAACATTGTCATGGTCTTCATGTCCCTCTACTCA
GTGTTATACATGTCAAGTTTACTTCCGGCCAAGATGTTTGCAATTGCAACAATAAACAAA
GCTGGGTGGGGCACATCTGGAAGGAAAACCATTGTCGTTAATTTCATAGGACTCATTCCC
GTATCGGTTTGGTTTACAATACTCCTGGGTGGTGTGATTTTCACCATTTATAAGGAATCT
AAAAAGCCATTCTCAGAATCCAAACAGACAGTTTTAATTGTTGGAACGTTGCTGTATGCA
TGCTATTGGGTCATGCTTTTGACACTGTACGTGGTTCTCATCAATAAATGTGGCAGGCGG
AAGAAGGGACAACAGTACGACATGGTGCTTGATGTATGA
|
| Protein Properties |
|---|
| Number of Residues
| 552 |
| Molecular Weight
| 63459.0 |
| Theoretical pI
| 8.82 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 12-32
- 46-66
- 375-395
- 403-423
- 430-450
- 476-496
- 511-531
|
| Protein Sequence
|
>Hyaluronan synthase 2
MHCERFLCILRIIGTTLFGVSLLLGITAAYIVGYQFIQTDNYYFSFGLYGAFLASHLIIQ
SLFAFLEHRKMKKSLETPIKLNKTVALCIAAYQEDPDYLRKCLQSVKRLTYPGIKVVMVI
DGNSEDDLYMMDIFSEVMGRDKSATYIWKNNYHVKGPGETDESHKESSQHVTQLVLSNKS
ICTMQKWGGKREVMYTAFRALGRSVDYVQVCDSDTMLDPASSVEMVKVLEEDPMVGGVGG
DVQILNKYDSWISFLSSVRYWMAFNIERACQSYFGCVQCISGPLGMYRNSLLHEFVEDWY
NQEFMGSQCSFGDDRHLTNRVLSLGYATKYTARSKCLTETPIEYLRWLNQQTRWSKSYFR
EWLYNAMWFHKHHLWMTYEAVITGFFPFFLIATVIQLFYRGKIWNTLLFLLTVQLVGLIK
SSFASCLRGNIVMVFMSLYSVLYMSSLLPAKMFAIATINKAGWGTSGRKTIVVNFIGLIP
VSVWFTILLGGVIFTIYKESKKPFSESKQTVLIVGTLLYACYWVMLLTLYVVLINKCGRR
KKGQQYDMVLDV
|
| External Links |
|---|
| GenBank ID Protein
| CAA06239.1 |
| UniProtKB/Swiss-Prot ID
| O97711 |
| UniProtKB/Swiss-Prot Entry Name
| HYAS2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AJ004951 |
| GeneCard ID
| HAS2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
