Showing Protein Hyaluronan synthase 2 (BMDBP00846)
Identification | |
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BMDB Protein ID | BMDBP00846 |
Secondary Accession Numbers | None |
Name | Hyaluronan synthase 2 |
Synonyms | Not Available |
Gene Name | HAS2 |
Protein Type | Enzyme |
Biological Properties | |
General Function | Cell wall/membrane/envelope biogenesis |
Specific Function | Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix (By similarity). |
Pathways |
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Reactions | Not Available |
GO Classification | Not Available |
Cellular Location | Not Available |
Gene Properties | |
Chromosome Location | 14 |
Locus | Not Available |
SNPs | HAS2 |
Gene Sequence |
>1659 bp ATGCATTGTGAGAGATTTCTATGTATCCTGAGAATAATTGGAACCACACTTTTTGGAGTC TCTCTCCTCCTTGGAATCACAGCTGCTTATATTGTTGGCTATCAATTTATCCAAACAGAT AATTACTATTTCTCTTTTGGACTGTATGGTGCCTTTTTAGCATCACACCTCATCATCCAA AGCCTGTTTGCCTTTTTGGAGCACCGGAAAATGAAAAAATCTCTAGAAACCCCCATTAAG TTGAACAAAACTGTTGCTCTTTGCATTGCTGCATATCAAGAAGATCCAGACTATTTGCGG AAATGTTTGCAATCTGTGAAAAGGCTAACCTACCCCGGAATTAAAGTTGTCATGGTCATA GATGGAAACTCGGAAGATGACCTTTACATGATGGACATCTTCAGTGAAGTCATGGGCAGG GACAAGTCAGCCACTTATATCTGGAAGAACAACTACCATGTGAAGGGTCCTGGAGAGACG GATGAGTCGCACAAAGAAAGCTCACAGCATGTCACCCAGTTGGTCTTGTCCAACAAGAGT ATTTGCACCATGCAAAAATGGGGTGGAAAAAGAGAAGTCATGTACACAGCCTTCAGAGCA CTGGGGCGAAGTGTGGATTATGTACAGGTTTGTGATTCAGACACCATGCTTGACCCAGCA TCATCTGTGGAGATGGTAAAAGTTTTAGAAGAAGATCCCATGGTTGGAGGTGTCGGGGGA GATGTCCAGATTTTAAACAAGTATGATTCCTGGATCTCCTTCCTCAGCAGTGTGAGATAC TGGATGGCTTTTAACATAGAAAGGGCCTGTCAGTCTTATTTCGGATGTGTCCAGTGCATT AGCGGACCTCTGGGAATGTACAGAAACTCCTTACTGCATGAATTTGTGGAAGACTGGTAC AATCAAGAATTTATGGGCAGCCAATGTAGTTTTGGAGATGACAGGCATCTAACGAACCGA GTGCTGAGTCTGGGCTATGCAACGAAATACACAGCTCGATCCAAGTGCCTTACTGAAACA CCTATAGAATATCTCAGATGGTTAAACCAGCAGACCCGCTGGAGCAAGTCGTACTTCCGA GAGTGGCTGTACAACGCTATGTGGTTTCATAAACATCACTTGTGGATGACCTATGAAGCC GTCATCACTGGGTTCTTCCCTTTCTTTCTCATTGCCACGGTAATCCAGCTCTTCTACAGG GGTAAAATTTGGAACACCCTCCTCTTCTTGTTAACTGTCCAGTTAGTGGGTCTCATAAAA TCATCTTTTGCCAGCTGCCTTAGAGGAAACATTGTCATGGTCTTCATGTCCCTCTACTCA GTGTTATACATGTCAAGTTTACTTCCGGCCAAGATGTTTGCAATTGCAACAATAAACAAA GCTGGGTGGGGCACATCTGGAAGGAAAACCATTGTCGTTAATTTCATAGGACTCATTCCC GTATCGGTTTGGTTTACAATACTCCTGGGTGGTGTGATTTTCACCATTTATAAGGAATCT AAAAAGCCATTCTCAGAATCCAAACAGACAGTTTTAATTGTTGGAACGTTGCTGTATGCA TGCTATTGGGTCATGCTTTTGACACTGTACGTGGTTCTCATCAATAAATGTGGCAGGCGG AAGAAGGGACAACAGTACGACATGGTGCTTGATGTATGA |
Protein Properties | |
Number of Residues | 552 |
Molecular Weight | 63459.0 |
Theoretical pI | 8.82 |
Pfam Domain Function | Not Available |
Signals |
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Transmembrane Regions |
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Protein Sequence |
>Hyaluronan synthase 2 MHCERFLCILRIIGTTLFGVSLLLGITAAYIVGYQFIQTDNYYFSFGLYGAFLASHLIIQ SLFAFLEHRKMKKSLETPIKLNKTVALCIAAYQEDPDYLRKCLQSVKRLTYPGIKVVMVI DGNSEDDLYMMDIFSEVMGRDKSATYIWKNNYHVKGPGETDESHKESSQHVTQLVLSNKS ICTMQKWGGKREVMYTAFRALGRSVDYVQVCDSDTMLDPASSVEMVKVLEEDPMVGGVGG DVQILNKYDSWISFLSSVRYWMAFNIERACQSYFGCVQCISGPLGMYRNSLLHEFVEDWY NQEFMGSQCSFGDDRHLTNRVLSLGYATKYTARSKCLTETPIEYLRWLNQQTRWSKSYFR EWLYNAMWFHKHHLWMTYEAVITGFFPFFLIATVIQLFYRGKIWNTLLFLLTVQLVGLIK SSFASCLRGNIVMVFMSLYSVLYMSSLLPAKMFAIATINKAGWGTSGRKTIVVNFIGLIP VSVWFTILLGGVIFTIYKESKKPFSESKQTVLIVGTLLYACYWVMLLTLYVVLINKCGRR KKGQQYDMVLDV |
External Links | |
GenBank ID Protein | CAA06239.1 |
UniProtKB/Swiss-Prot ID | O97711 |
UniProtKB/Swiss-Prot Entry Name | HYAS2_BOVIN |
PDB IDs | Not Available |
GenBank Gene ID | AJ004951 |
GeneCard ID | HAS2 |
GenAtlas ID | Not Available |
HGNC ID | Not Available |
References | |
General References | Not Available |