Showing Protein Exostosin-1 (BMDBP00847)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00847 |
| Secondary Accession Numbers | None |
| Name | Exostosin-1 |
| Synonyms | Not Available |
| Gene Name | EXT1 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in glucuronosyl-N-acetylglucosaminyl-proteogly |
| Specific Function | Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). |
| Pathways |
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| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 14 |
| Locus | Not Available |
| SNPs | EXT1 |
| Gene Sequence |
>2241 bp ATGCAGGCCAAAAAACGCTATTTCATCCTGCTCTCAGCTGGCTCTTGTCTCGCCCTTTTG TTTTATTTCGGAGGCTTGCAGTTTAGGGCATCGAGAAGCCACAGCCGGAGAGAAGAGCAC AGCGGTCGGAATGGCTTGCACCATCCGAGTCCGGATCATTTCTGGCCCCGCTTCCCGGAC GCTCTGCGCCCCTTCGTTCCCTGGGATCAATTGGAAAACGAGGATTCCAGTGTGCACGTT TCGCCCCGGCAGAAGCGAGAGGCCAACTCGAGCATCTACAAAGGCAAGAAGTGCCGCATG GAGTCCTGCTTCGATTTCACCCTTTGCAAGAAAAACGGCTTCAAAGTCTACGTCTACCCA CAGCAAAAAGGGGAGAAAATTGCTGAAAGTTACCAAAACATTCTAGCGGCCATCGAGGGC TCCAGGTTCTATACCTCGGACCCCAGCCAGGCGTGCCTCTTTGTCCTGAGTCTGGACACT TTAGACCGAGACCAGTTGTCACCTCAGTATGTGCACAATTTGAGATCCAAAGTGCAGAGT CTCCACTTGTGGAACAACGGTAGGAATCATTTAATTTTTAATTTATATTCCGGCACTTGG CCTGACTACACCGAGGACGTGGGGTTTGACATCGGCCAGGCGATGCTGGCTAAAGCCAGC ATCAGTACTGAAAACTTCCGACCCAACTTTGATGTTTCTATTCCCCTCTTTTCTAAGGAT CATCCCAGGACAGGAGGGGAGAGGGGGTTTTTGAAGTTTAACACTATCCCTCCTCTCAGG AAGTACATGCTGGTCTTCAAGGGGAAGAGGTACCTGACAGGGATAGGGTCAGACACCAGG AATGCCTTATATCACGTCCATAACGGGGAGGACGTAGTGCTGCTCACCACCTGCAAGCAT GGCAAAGACTGGCAGAAGCACAAGGATTCTCGCTGTGACCGGGACAACACCGAGTACGAG AAATATGATTATCGGGAAATGCTGCACAATGCCACTTTCTGTCTGGTTCCTCGTGGTCGC AGGCTTGGGTCCTTCAGGTTCCTGGAGGCTCTGCAGGCCGCCTGTGTCCCTGTGATGCTC AGCAATGGATGGGAGTTGCCATTCTCTGAAGTGATTAATTGGAACCAAGCTGCCGTCATA GGCGATGAGAGATTGTTATTACAGATTCCTTCTACAATCAGGTCTATTCATCAGGATAAA ATCCTAGCACTTAGACAGCAGACACAATTCTTGTGGGAGGCTTATTTTTCTTCAGTTGAG AAGATTGTATTAACTACACTAGAGATTATTCAGGACAGAATATTCAAGCACATATCACGC AACAGTTTAATATGGAACAAACATCCTGGGGGATTGTTCGTCCTACCACAGTATTCATCT TATCTGGGAGATTTCCCTTACTACTATGCTAATTTAGGTTTAAAGCCCCCCTCCAAATTC ACTGCAGTCATCCACGCGGTGACCCCCCTGGTCTCTCAGTCCCAGCCAGTGTTGAAACTC CTCGTGGCTGCAGCCAAGTCCCAGTACTGTGCCCAGATCATAGTTCTATGGAATTGTGAC AAGCCCCTTCCAGCCAAACACCGCTGGCCTGCCACTTCTGTGCCTGTCATTGTCATTGAA GGAGAAAGCAAGGTGATGAGCAGCCGTTTCCTGCCCTACGACAACATCATCACAGATGCT GTGCTCAGCCTTGACGAGGACACCGTGCTTTCAACCACGGAGGTGGATTTTGCCTTCACC GTGTGGCAGAGCTTCCCCGAGAGGATTGTGGGGTACCCCGCACGCAGCCATTTCTGGGAC AACTCTAAGGAGCGGTGGGGCTACACGTCCAAGTGGACGAACGACTACTCCATGGTGTTG ACGGGAGCTGCTATTTACCACAAATATTATCACTACCTTTACACCCATTACCTGCCAGCC AGCCTGAAGAACATGGTGGACCAATTGGCCAACTGTGAGGACATACTCATGAATTTCCTG GTGTCTGCTGTGACAAAATTGCCTCCAATCAAAGTGACCCAAAAGAAGCAGTATAAGGAG ACAATGATGGGACAGACCTCTCGGGCTTCCCGCTGGGCTGACCCTGACCACTTTGCCCAG CGACAAAGCTGCATGAATACGTTTGCCAGCTGGTTTGGCTACATGCCGCTGATCCACTCT CAGATGAGGCTGGACCCCGTCCTCTTTAAAGACCAGGTCTCTATTCTGCGGAAGAAATAC CGAGACATCGAGCGGCTTTGA |
| Protein Properties | |
| Number of Residues | 746 |
| Molecular Weight | 86299.0 |
| Theoretical pI | 9.34 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions |
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| Protein Sequence |
>Exostosin-1 MQAKKRYFILLSAGSCLALLFYFGGLQFRASRSHSRREEHSGRNGLHHPSPDHFWPRFPD ALRPFVPWDQLENEDSSVHVSPRQKREANSSIYKGKKCRMESCFDFTLCKKNGFKVYVYP QQKGEKIAESYQNILAAIEGSRFYTSDPSQACLFVLSLDTLDRDQLSPQYVHNLRSKVQS LHLWNNGRNHLIFNLYSGTWPDYTEDVGFDIGQAMLAKASISTENFRPNFDVSIPLFSKD HPRTGGERGFLKFNTIPPLRKYMLVFKGKRYLTGIGSDTRNALYHVHNGEDVVLLTTCKH GKDWQKHKDSRCDRDNTEYEKYDYREMLHNATFCLVPRGRRLGSFRFLEALQAACVPVML SNGWELPFSEVINWNQAAVIGDERLLLQIPSTIRSIHQDKILALRQQTQFLWEAYFSSVE KIVLTTLEIIQDRIFKHISRNSLIWNKHPGGLFVLPQYSSYLGDFPYYYANLGLKPPSKF TAVIHAVTPLVSQSQPVLKLLVAAAKSQYCAQIIVLWNCDKPLPAKHRWPATSVPVIVIE GESKVMSSRFLPYDNIITDAVLSLDEDTVLSTTEVDFAFTVWQSFPERIVGYPARSHFWD NSKERWGYTSKWTNDYSMVLTGAAIYHKYYHYLYTHYLPASLKNMVDQLANCEDILMNFL VSAVTKLPPIKVTQKKQYKETMMGQTSRASRWADPDHFAQRQSCMNTFASWFGYMPLIHS QMRLDPVLFKDQVSILRKKYRDIERL |
| External Links | |
| GenBank ID Protein | AAI40569.1 |
| UniProtKB/Swiss-Prot ID | A5D7I4 |
| UniProtKB/Swiss-Prot Entry Name | EXT1_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC140568 |
| GeneCard ID | EXT1 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |