| Identification |
|---|
| BMDB Protein ID
| BMDBP00858 |
| Secondary Accession Numbers
| None |
| Name
| Alanine aminotransferase 1 |
| Synonyms
|
Not Available
|
| Gene Name
| GPT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity). |
| Pathways
|
- Alanine Metabolism
- Amino-acid degradation
- Glucose-Alanine Cycle
- Glutamate Metabolism
- L-alanine degradation via transaminase pathway
- Pyruvate from L-alanine: step 1/1
- Urea Cycle
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 14 |
| Locus
| Not Available |
| SNPs
| GPT |
| Gene Sequence
|
>1491 bp
ATGGCCTTGAGGGCAGGTGAGCACAGCCAGGAGGCAGCAAATGGGCTGAAGGAGAAGGTG
CTGACACTGGACTCCATGAATCCTTATGTCCGGAGGGTGGAGTATGCGGTGCGAGGCCCC
ATCGTTCAGCGGGCACTGGAGCTGGAGCAGGAGCTGCGCCAGGGCGTAAAGAAGCCCTTC
ACCGAGGTCATCCGCGCCAACATCGGGGACGCACAGGCCATGGGGCAGATCCCTATCACC
TTCCCGCGCCAGGTCCTGGCCCTCTGCGTCCATCCCGATCTCCTGAACAGCCCCGACTTC
CCCGACGACGCCAAGAGGAGGGCGGAGCGCATCTTGCAGGCGTGTGGGGGCCACAGCCTG
GGGGCCTACAGCATCAGCGCTGGCGTCCAGATGATCCGTGAGGATGTGGCGCGGTACATC
GAGCGGCGCGATGGAGGCATTCCTGCCGACCCCAATAACATCTTTCTGTCCACGGGGGCC
AGCGATGCCATTGTGACGGTGCTGAAGTTGCTGGTAACCGGCGAGGGTCGCACGCGCACG
GGCGTGCTTATCCCTATCCCTCAGTATCCACTCTACTCCGCCGCGCTGGCCGAGTTCAAT
GCGGTGCAGGTGGACTACTACCTGGACGAGGAGCGTGCCTGGGCGCTCGATGTGGCCGAG
CTGCGGCGCGCGCTGCGCCAGGCGCGTGACCACTGCCGCCCCCGCGCGCTCTGCGTCATC
AACCCCGGGAACCCCACCGGGCAGGTGCAGACCCGCGAGTGCATCGAGGACGTGATCCGC
TTCGCCTATGAGGAGAAGCTTTTCCTATTGGCCGATGAGGTGTACCAAGACAACGTGTAT
GCCGAGAGCTCGCAGTTCCACTCGTTCAAGAAGGTGCTCACGGAGATGGGGCCGCCGTAC
GCGGCGCAACAGGAGCTCGCCTCCTTCCACTCGATCTCCAAGGGCTACATGGGCGAGTGC
GGCTTCCGCGGCGGCTACGTGGAGGTGGTGAATATGGACGCTGCGGTGAAGCAGCAGATG
CAGAAGCTGCGGAGCGTGCGGCTGTGCCCACCCACCCCGGGCCAGGTCCTGCTCGACGTG
GCTGTCAGCCCGCCGGCGCCCTCAGACCCCTCCTTCCCGCGGTTCCAGGCGGAGAGGAGG
GCGGTGCTGGCCGAGCTGGCTGCCAAGGCCAAGCTCACGGAGCAGGTCTTCAACGAAGCT
CCCGGCATCCGCTGCAATCCGGTGCAGGGCGCCATGTATTCGTTCCCGCGCGTGCAGCTG
CCCCCGCGTGCGGTGCAGCGCGCTCAGGAGCTGGGCCTGGCTCCCGACATGTTCTTCTGC
CTGCGCCTCCTAGAGGAGACTGGCATCTGCGTGGTGCCTGGGAGTGGCTTTGGACAACGG
GAAGGCACCTACCACTTTCGGATGACTATTCTGCCCCCCATGGAGAAGCTACGGCCCCTG
CTGGAGAAGCTGAGCCAGTTCCATGCGAAGTTCACCCGCGAGTACTCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 496 |
| Molecular Weight
| 55275.0 |
| Theoretical pI
| 7.42 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Alanine aminotransferase 1
MALRAGEHSQEAANGLKEKVLTLDSMNPYVRRVEYAVRGPIVQRALELEQELRQGVKKPF
TEVIRANIGDAQAMGQIPITFPRQVLALCVHPDLLNSPDFPDDAKRRAERILQACGGHSL
GAYSISAGVQMIREDVARYIERRDGGIPADPNNIFLSTGASDAIVTVLKLLVTGEGRTRT
GVLIPIPQYPLYSAALAEFNAVQVDYYLDEERAWALDVAELRRALRQARDHCRPRALCVI
NPGNPTGQVQTRECIEDVIRFAYEEKLFLLADEVYQDNVYAESSQFHSFKKVLTEMGPPY
AAQQELASFHSISKGYMGECGFRGGYVEVVNMDAAVKQQMQKLRSVRLCPPTPGQVLLDV
AVSPPAPSDPSFPRFQAERRAVLAELAAKAKLTEQVFNEAPGIRCNPVQGAMYSFPRVQL
PPRAVQRAQELGLAPDMFFCLRLLEETGICVVPGSGFGQREGTYHFRMTILPPMEKLRPL
LEKLSQFHAKFTREYS
|
| External Links |
|---|
| GenBank ID Protein
| AAI34584.1 |
| UniProtKB/Swiss-Prot ID
| A4IFH5 |
| UniProtKB/Swiss-Prot Entry Name
| ALAT1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC134583 |
| GeneCard ID
| GPT |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
