| Identification |
|---|
| BMDB Protein ID
| BMDBP00859 |
| Secondary Accession Numbers
| None |
| Name
| Tyrosine aminotransferase |
| Synonyms
|
Not Available
|
| Gene Name
| TAT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity for phenylalanine (By similarity). |
| Pathways
|
- Acetoacetate and fumarate from L-phenylalanine: step 2/6
- Amino-acid degradation
- L-phenylalanine degradation
- Phenylalanine and Tyrosine Metabolism
- Tyrosine Metabolism
|
| Reactions
|
| L-Tyrosine + Oxoglutaric acid → 4-Hydroxyphenylpyruvic acid + L-Glutamic acid |
details
|
| L-Phenylalanine + Oxoglutaric acid → Phenylpyruvic acid + L-Glutamic acid |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| Not Available |
| SNPs
| TAT |
| Gene Sequence
|
>1344 bp
ATGCAGGATCACGGCAGCCTCCCCTCAGTTCTGGATGTGCATGTCAACGTTGCTGGGAGA
AGCTCTGTGCTGGGAAAAGTGAAAAGCAGGAAGGCCAGATGGTCCGTGAGGCCCTCGGAC
ATGTCCAACAAAACTTTCAATCCCATCCGGGCCATTGTGGACAACATGAAGGTGAAGCCA
AATCCAAACAAGACCATGATTGCTTTGTCGATTGGGGACCCTACTGTATTTGGAAACCTG
CCGACAGATCCTGAAGTTACCCAAGCAATGAAAGATGCCCTCGACTCAGGGAAGTTTAAT
GGCTATGTCCCCTCCATTGGCTACTTATCCAGTCGGGAGGAAGTTGCTTCTTATTACCAC
TGTCCCGAGGCACCCCTGGAAGCTAAGGATGTCATTCTGACAAGTGGCTGCAGTCAGGCT
ATTGAACTGTGTTTGGCTGTGTTGGCCAACCCAGGGCAAAACATCCTAGTTCCGAGACCT
GGCTTCTCTCTCTACAGGACTCTGGCTGAATCTATGGGAATTGAGGTCAAACTCTACAAT
TTATTGCCAGAGAAGAATTGGGAAATTGACCTGAAACAATTAGAATCTCTGATTGATGAA
AAGACAGTTTGTCTTATTGTCAACAATCCATCAAACCCTTGTGGGTCAGTGTTCAGTAGA
CGTCATCTCCAGAAAATTTTGGCAGTGGCTGCAAGGCAATGTGTTCCCATTTTAGCTGAT
GAGATCTATGGAGACATGGTGTTTTCAGATTCCAAATTTGAGCCTCTGGCCACCCTCAGC
AGCAAAGTCCCCATCCTGTCCTGTGGAGGGCTGGCCAAGCGCTGGCTGGTTCCTGGCTGG
AGGATGGGCTGGATCCTTATCCATGACCGAAGAGATATTTTTGGCAATGAGATCCGAGAT
GGGCTGACGAAGCTAAGTCAACGGATCCTGGGCCCCTGCACCCTTGTCCAGGGAGCTCTG
AAAAGCATCCTGTGTCGCACCCCTCGTGTGTTCTACCACAACACTCTAAGCTTCCTCAAG
TCCAATGCGGATCTCTGCTATGGGGCATTGGCTGCCATCCCCGGACTCCGGCCCATTCAC
CCTTCTGGGGCCATGTACCTCATGGTTGGAATTGAGATGGAACATTTCCCAGAATTTGAG
AATGATGTGGAGTTCACGGAGCAGTTAGTTGCTGAGCAATCTGTCCACTGCCTCCCAGCA
ACGTGCTTTGAGTATCCAAATTTCTTCCGAGTGGTAATCACAGTCCCTGAAGTGATGATG
CTGGAGGCCTGTAGCCGGATCCAGGAGTTCTGTGAACAGCACTACCATTGTGCTGAAGGG
AGCCAGGAGGAATGTGACAAATAG
|
| Protein Properties |
|---|
| Number of Residues
| 447 |
| Molecular Weight
| 49691.0 |
| Theoretical pI
| 6.43 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Tyrosine aminotransferase
MQDHGSLPSVLDVHVNVAGRSSVLGKVKSRKARWSVRPSDMSNKTFNPIRAIVDNMKVKP
NPNKTMIALSIGDPTVFGNLPTDPEVTQAMKDALDSGKFNGYVPSIGYLSSREEVASYYH
CPEAPLEAKDVILTSGCSQAIELCLAVLANPGQNILVPRPGFSLYRTLAESMGIEVKLYN
LLPEKNWEIDLKQLESLIDEKTVCLIVNNPSNPCGSVFSRRHLQKILAVAARQCVPILAD
EIYGDMVFSDSKFEPLATLSSKVPILSCGGLAKRWLVPGWRMGWILIHDRRDIFGNEIRD
GLTKLSQRILGPCTLVQGALKSILCRTPRVFYHNTLSFLKSNADLCYGALAAIPGLRPIH
PSGAMYLMVGIEMEHFPEFENDVEFTEQLVAEQSVHCLPATCFEYPNFFRVVITVPEVMM
LEACSRIQEFCEQHYHCAEGSQEECDK
|
| External Links |
|---|
| GenBank ID Protein
| AAX46645.1 |
| UniProtKB/Swiss-Prot ID
| Q58CZ9 |
| UniProtKB/Swiss-Prot Entry Name
| ATTY_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT021798 |
| GeneCard ID
| TAT |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
