| Identification |
|---|
| BMDB Protein ID
| BMDBP00860 |
| Secondary Accession Numbers
| None |
| Name
| Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| ALDH4A1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity). |
| Pathways
|
- Amino-acid degradation
- Arginine and Proline Metabolism
- Glutamate Metabolism
- L-glutamate from L-proline: step 2/2
- L-proline degradation into L-glutamate
|
| Reactions
|
| 1-Pyrroline-5-carboxylic acid + NAD + 2 Water → L-Glutamic acid + NADH |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| Not Available |
| SNPs
| ALDH4A1 |
| Gene Sequence
|
>1692 bp
ATGCTGCTGCGTTCGGCCGCGCTCTGCCGCGCCCTACTGGCCCGCCGGGGGAGGGCGGCC
GGGCTGTGTCGGAGGTGCGTCTCCTCCCTCCAGGTGGCCAACGAGCCCGTGCTGGCATTC
ACGCAGGGCAGTCCTGAGCGAGATGCGCTGCAGAAGGCCCTGAAGGAGCTGAAGGGCCGG
ACGGAGGCCATCCCATGCGTGGTGGGGGACGAGGAGGTCTGGACCTCGGATGTGCGGTAC
CAGGCGTCGCCCTTCAACCATGGACACAAGGTGGCCAAGTTTTGCTACGCAGACAAGGCC
CTGCTCCACAGAGCCATCGGGGCCGCCTTGGCTGCCAGGAAGGAGTGGGACCTGAAGCCT
GTGGCGGACCGGGCGCAGGTCTTCCTGAAGGCAGCTGACCTGCTGAGCGGGCCACGCAGG
GCCGAGGTCCTGGCCAAGACCATGGTGGGGCAGGGGAAGACAGTGATCCAGGCGGAGATC
GACGCTGCGGCTGAACTCATCGACTTCTTCCGCTTCAATGCCAAGTTCGCCATGGAGCTG
GAAGGCGAGCAGCCCCTCAGCGTGCCGCCCAGCACCAACAGCATGCTGTACCGGGGGCTG
GAGGGCTTCGTGGCGGCCATCTCCCCCTTCAACTTCACTGCGATCGGGGGCAACCTGGCA
GGGGCTCCGGCCTTGATGGGCAACGTGGTCCTGTGGAAGCCCAGCGACACTGCCATGCTG
GCCAGCTATGCCGTCTACCGCATCCTCAGGGAGGCCGGGCTGCCCCCCAACATCATCCAG
TTTGTGCCAGCCGACGGGCCCACCTTCGGGGACACTGTCACCAGCTCAGAGCACCTGTGT
GGCATCAACTTCACAGGCAGTGTGCCCACCTTCAAACACCTGTGGAAGCAGGTGGCCCAG
AACCTGGACCGGTTCCGAACCTTCCCCCGCCTGGCTGGAGAGTGCGGGGGCAAGAACTTC
CACTTTGTGCACCGCTCGGCCGACGTGGACAGCGTGGTGAGTGGGACCCTGCGCTCGGCC
TTTGAGTACGGCGGCCAGAAGTGCTCAGCGTGCTCCCGCCTCTACGCGCCCCGCTCGCTG
TGGCCGCAGATCAAAGGGCGGCTGCTGGAGGAGCTCGGTGGGATCAAAGTGGGCAATCCT
GCAGAGGATTTTGGGACCTTCTTCTCTGCCGTGATTGATGCCAAGTCCTTCGGTCGCATC
CGGAAGTGGCTGGAGCACGCCCGCTCCTCGCCCAGCCTCACCATCCTGGCCGGGGGCCAC
TGTGACGACTCTGTGGGCTACTTTGTGGAGCCGTGCATCGTCGAGACCAAGGACCCCCAG
GACCCCATCATGAAGGAGGAGATCTTCGGTCCCGTGCTGGCCGTGTACGTCTACCCGGAC
GAGGAATACAAGGAGACGCTGCGGCTGGTCGACAGCACCACCAGCTACGGCCTCACGGGG
GCAGTGTTCGCCCAGGATAAGGACGTTCTCCGGGAGGCCACAGAGCTGCTGAGGCACGCC
GCGGGCAACTTCTACATCAACGACAAGTCCACCGGCTCGGTGGTGGGCCAGCAGCCCTTT
GGGGGCGCTCGAGCCTCGGGAACCAATGACAAGCCAGGCGGCCCCCACTATGTCCTGCGG
TGGACGTCGCCCCAGGTCATCAAGGAGACGCACGGGCCTCTGGGGGACTGGCGCTACCCG
TACATGCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 563 |
| Molecular Weight
| 61495.0 |
| Theoretical pI
| 8.2 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
MLLRSAALCRALLARRGRAAGLCRRCVSSLQVANEPVLAFTQGSPERDALQKALKELKGR
TEAIPCVVGDEEVWTSDVRYQASPFNHGHKVAKFCYADKALLHRAIGAALAARKEWDLKP
VADRAQVFLKAADLLSGPRRAEVLAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKFAMEL
EGEQPLSVPPSTNSMLYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML
ASYAVYRILREAGLPPNIIQFVPADGPTFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ
NLDRFRTFPRLAGECGGKNFHFVHRSADVDSVVSGTLRSAFEYGGQKCSACSRLYAPRSL
WPQIKGRLLEELGGIKVGNPAEDFGTFFSAVIDAKSFGRIRKWLEHARSSPSLTILAGGH
CDDSVGYFVEPCIVETKDPQDPIMKEEIFGPVLAVYVYPDEEYKETLRLVDSTTSYGLTG
AVFAQDKDVLREATELLRHAAGNFYINDKSTGSVVGQQPFGGARASGTNDKPGGPHYVLR
WTSPQVIKETHGPLGDWRYPYMQ
|
| External Links |
|---|
| GenBank ID Protein
| AAI34525.1 |
| UniProtKB/Swiss-Prot ID
| A7YWE4 |
| UniProtKB/Swiss-Prot Entry Name
| AL4A1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC134524 |
| GeneCard ID
| ALDH4A1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
