Showing Protein Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (BMDBP00860)
| Identification | |||
|---|---|---|---|
| BMDB Protein ID | BMDBP00860 | ||
| Secondary Accession Numbers | None | ||
| Name | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial | ||
| Synonyms | Not Available | ||
| Gene Name | ALDH4A1 | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Energy production and conversion | ||
| Specific Function | Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity). | ||
| Pathways |
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| Reactions |
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| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 2 | ||
| Locus | Not Available | ||
| SNPs | ALDH4A1 | ||
| Gene Sequence |
>1692 bp ATGCTGCTGCGTTCGGCCGCGCTCTGCCGCGCCCTACTGGCCCGCCGGGGGAGGGCGGCC GGGCTGTGTCGGAGGTGCGTCTCCTCCCTCCAGGTGGCCAACGAGCCCGTGCTGGCATTC ACGCAGGGCAGTCCTGAGCGAGATGCGCTGCAGAAGGCCCTGAAGGAGCTGAAGGGCCGG ACGGAGGCCATCCCATGCGTGGTGGGGGACGAGGAGGTCTGGACCTCGGATGTGCGGTAC CAGGCGTCGCCCTTCAACCATGGACACAAGGTGGCCAAGTTTTGCTACGCAGACAAGGCC CTGCTCCACAGAGCCATCGGGGCCGCCTTGGCTGCCAGGAAGGAGTGGGACCTGAAGCCT GTGGCGGACCGGGCGCAGGTCTTCCTGAAGGCAGCTGACCTGCTGAGCGGGCCACGCAGG GCCGAGGTCCTGGCCAAGACCATGGTGGGGCAGGGGAAGACAGTGATCCAGGCGGAGATC GACGCTGCGGCTGAACTCATCGACTTCTTCCGCTTCAATGCCAAGTTCGCCATGGAGCTG GAAGGCGAGCAGCCCCTCAGCGTGCCGCCCAGCACCAACAGCATGCTGTACCGGGGGCTG GAGGGCTTCGTGGCGGCCATCTCCCCCTTCAACTTCACTGCGATCGGGGGCAACCTGGCA GGGGCTCCGGCCTTGATGGGCAACGTGGTCCTGTGGAAGCCCAGCGACACTGCCATGCTG GCCAGCTATGCCGTCTACCGCATCCTCAGGGAGGCCGGGCTGCCCCCCAACATCATCCAG TTTGTGCCAGCCGACGGGCCCACCTTCGGGGACACTGTCACCAGCTCAGAGCACCTGTGT GGCATCAACTTCACAGGCAGTGTGCCCACCTTCAAACACCTGTGGAAGCAGGTGGCCCAG AACCTGGACCGGTTCCGAACCTTCCCCCGCCTGGCTGGAGAGTGCGGGGGCAAGAACTTC CACTTTGTGCACCGCTCGGCCGACGTGGACAGCGTGGTGAGTGGGACCCTGCGCTCGGCC TTTGAGTACGGCGGCCAGAAGTGCTCAGCGTGCTCCCGCCTCTACGCGCCCCGCTCGCTG TGGCCGCAGATCAAAGGGCGGCTGCTGGAGGAGCTCGGTGGGATCAAAGTGGGCAATCCT GCAGAGGATTTTGGGACCTTCTTCTCTGCCGTGATTGATGCCAAGTCCTTCGGTCGCATC CGGAAGTGGCTGGAGCACGCCCGCTCCTCGCCCAGCCTCACCATCCTGGCCGGGGGCCAC TGTGACGACTCTGTGGGCTACTTTGTGGAGCCGTGCATCGTCGAGACCAAGGACCCCCAG GACCCCATCATGAAGGAGGAGATCTTCGGTCCCGTGCTGGCCGTGTACGTCTACCCGGAC GAGGAATACAAGGAGACGCTGCGGCTGGTCGACAGCACCACCAGCTACGGCCTCACGGGG GCAGTGTTCGCCCAGGATAAGGACGTTCTCCGGGAGGCCACAGAGCTGCTGAGGCACGCC GCGGGCAACTTCTACATCAACGACAAGTCCACCGGCTCGGTGGTGGGCCAGCAGCCCTTT GGGGGCGCTCGAGCCTCGGGAACCAATGACAAGCCAGGCGGCCCCCACTATGTCCTGCGG TGGACGTCGCCCCAGGTCATCAAGGAGACGCACGGGCCTCTGGGGGACTGGCGCTACCCG TACATGCAGTGA |
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| Protein Properties | |||
| Number of Residues | 563 | ||
| Molecular Weight | 61495.0 | ||
| Theoretical pI | 8.2 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
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| Transmembrane Regions | Not Available | ||
| Protein Sequence |
>Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial MLLRSAALCRALLARRGRAAGLCRRCVSSLQVANEPVLAFTQGSPERDALQKALKELKGR TEAIPCVVGDEEVWTSDVRYQASPFNHGHKVAKFCYADKALLHRAIGAALAARKEWDLKP VADRAQVFLKAADLLSGPRRAEVLAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKFAMEL EGEQPLSVPPSTNSMLYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML ASYAVYRILREAGLPPNIIQFVPADGPTFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ NLDRFRTFPRLAGECGGKNFHFVHRSADVDSVVSGTLRSAFEYGGQKCSACSRLYAPRSL WPQIKGRLLEELGGIKVGNPAEDFGTFFSAVIDAKSFGRIRKWLEHARSSPSLTILAGGH CDDSVGYFVEPCIVETKDPQDPIMKEEIFGPVLAVYVYPDEEYKETLRLVDSTTSYGLTG AVFAQDKDVLREATELLRHAAGNFYINDKSTGSVVGQQPFGGARASGTNDKPGGPHYVLR WTSPQVIKETHGPLGDWRYPYMQ |
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| External Links | |||
| GenBank ID Protein | AAI34525.1 | ||
| UniProtKB/Swiss-Prot ID | A7YWE4 | ||
| UniProtKB/Swiss-Prot Entry Name | AL4A1_BOVIN | ||
| PDB IDs | Not Available | ||
| GenBank Gene ID | BC134524 | ||
| GeneCard ID | ALDH4A1 | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||