| Identification |
|---|
| BMDB Protein ID
| BMDBP00861 |
| Secondary Accession Numbers
| None |
| Name
| Kynurenine--oxoglutarate transaminase 3 |
| Synonyms
|
Not Available
|
| Gene Name
| KYAT3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro) (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| Not Available |
| SNPs
| KYAT3 |
| Gene Sequence
|
>1368 bp
ATGTTTTTGGCCTGGGAGAGACTCTGCACCCTTAGCTGTAGACCTAAATTCCTGAAGACA
GTTTGGGCTTCAAAAATCCTTGGACTCTCTACTTCTGCTAAAATGTCTTTGAGATTCAAA
AATGCAAAACGAATTGAAGGCCTTGATAGCAATATATGGATTGAATTTACCAAACTGGCT
GCAGACCCTTCTGTTGTGAATCTTGGCCAAGGCCTTCCAGATATATCCCCTCCTGTATAT
GTAAAGGAAGAATTATCCAAGATTGCAGCAATTGATAATCTGAATCAGTACACACGGGGC
TTTGGTCATCCATCACTTGTGAAAGCTCTGTCCTGCCTATATGAAAAGTTTTATCACAAT
AAAATCAATCCAAATGAAGAAATCCTTGTGACAGTAGGAGCATATGGATCTCTTTTTAAT
GCCATTCAAGGATTGATTGATGAGGGGGATGAAGTCATAGTGATAGTGCCTTTCTTTGAC
TGCTATGAGTCCATGGTGAGAATGGCTGGAGCAACACCTGTTTTTGTTCCCCTGAGATGT
AAACCTGTTGATGGGAAAAAATGCTCTAGTTCTGACTGGACCTTAGATCCTCAAGAACTG
GCAAGCAAATTTAATTCCAAAACCAAAGCTATAATACTAAATACTCCACATAACCCCCTT
GGCAAGGTGTATACCAAAGAGGAACTCCAAGTAATTGCCGACCTTTGCATCAAATATGAC
ACACTCTGCATCAGTGATGAGGTTTATGAATGGCTTGTATATACTGGAAATAAGCATTTT
AAAATAGCCACTTTTCCAGGTATGTGGGAGAGAACAATAACCATAGGAAGTGCTGGAAAG
ACTTTCAGTGTAACTGGCTGGAAGCTTGGCTGGTCCATTGGTCCTAAACATTTGATAAAA
CATTTACAGACAGTTCAGCAAAACACCGTTTATACTTGTGCAACCCCTTTACAGGAAGCC
TTGGCTCAAGCTTTCTGGATTGACATCAAGCGCATGGATGACCCAGAATGTTACTTCAAT
TCTTTGCCAAAAGAGTTAGAAGTAAAAAGAGATCGGATGGTACATTTACTTGAAAGTGTT
GGCCTAAAATCCATAGTTCCTGATGGGGGATACTTCATCATTGCTGACGTGTCTTTGCTA
GATGTAGACCTCTTGGATATGAAGGACAGCAATGAACCTTATGACTATAAATTCGTGAAA
TGGATGATTAAAAATAAGAAACTGTCAGCCATCCCAGTTTCAGCATTCTGTAATGCAGAA
ACCAAATCACAGTTTGAGAAATTTGTGCGATTTTGCTTCATTAAAAAAGACAGTACACTG
GATGCCGCTGAAGAAATCATCAAGGCATGGAGTAGACAGAACTCTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 455 |
| Molecular Weight
| 51472.0 |
| Theoretical pI
| 7.82 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Kynurenine--oxoglutarate transaminase 3
MFLAWERLCTLSCRPKFLKTVWASKILGLSTSAKMSLRFKNAKRIEGLDSNIWIEFTKLA
ADPSVVNLGQGLPDISPPVYVKEELSKIAAIDNLNQYTRGFGHPSLVKALSCLYEKFYHN
KINPNEEILVTVGAYGSLFNAIQGLIDEGDEVIVIVPFFDCYESMVRMAGATPVFVPLRC
KPVDGKKCSSSDWTLDPQELASKFNSKTKAIILNTPHNPLGKVYTKEELQVIADLCIKYD
TLCISDEVYEWLVYTGNKHFKIATFPGMWERTITIGSAGKTFSVTGWKLGWSIGPKHLIK
HLQTVQQNTVYTCATPLQEALAQAFWIDIKRMDDPECYFNSLPKELEVKRDRMVHLLESV
GLKSIVPDGGYFIIADVSLLDVDLLDMKDSNEPYDYKFVKWMIKNKKLSAIPVSAFCNAE
TKSQFEKFVRFCFIKKDSTLDAAEEIIKAWSRQNS
|
| External Links |
|---|
| GenBank ID Protein
| AAI20068.1 |
| UniProtKB/Swiss-Prot ID
| Q0P5G4 |
| UniProtKB/Swiss-Prot Entry Name
| KAT3_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC120067 |
| GeneCard ID
| KYAT3 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
