| Identification |
|---|
| BMDB Protein ID
| BMDBP00862 |
| Secondary Accession Numbers
| None |
| Name
| Glutamate decarboxylase 1 |
| Synonyms
|
Not Available
|
| Gene Name
| GAD1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Catalyzes the production of GABA. |
| Pathways
|
- Aspartate Metabolism
- beta-Alanine Metabolism
- Glutamate Metabolism
- Taurine and Hypotaurine Metabolism
|
| Reactions
|
| L-Aspartic acid → Beta-Alanine + Carbon dioxide |
details
|
| L-Glutamic acid → Gamma-Aminobutyric acid + Carbon dioxide |
details
|
| 3-Sulfinoalanine → Hypotaurine + Carbon dioxide |
details
|
| Cysteic acid → Taurine + Carbon dioxide |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| 2q21 |
| SNPs
| GAD1 |
| Gene Sequence
|
>1785 bp
ATGGCGTCTTCGACCCCTTCTTCGTCCGCAACCTCCTCGAACGCGGGAGCGGACCCCAAT
ACTACCAACCTGCGCCCCACAACGTATGACACCTGGTGCGGCGTGGCCCATGGATGCACC
AGAAAACTGGGGCTGAAGATCTGCGGCTTCTTGCAGAGGACCAACAGCCTGGAAGAGAAG
AGCAGGCTTGTGAGCGCCTTCAAGGAGAGGCAGTCCTCCAAGAACCTGCTTTCCTGTGAA
AACAGTGACAAGGATGGCCGCTTCCGCCGCACAGAGACAGACTTCTCCAACCTGTTCGCC
CGAGATCTGCTTCCGGCTAAGAACGGGGAGGAGCAAACTGTGCAATTCCTGTTGGAGGTG
GTAGACATACTCCTCAACTATGTCCGGAAGACGTTCGATCGCTCCACCAAAGTGCTGGAC
TTCCACCACCCCCACCAGCTGCTGGAAGGCATGGAGGGCTTCAACTTGGAACTCTCTGAC
CACCCCGAGTCCCTGGAGCAGATCCTGGTTGACTGCAGAGACACCCTGAAATATGGGGTC
CGCACAGGTCATCCACGATTTTTCAACCAGCTCTCCACAGGATTGGATATCATTGGTTTA
GCTGGCGAGTGGCTGACATCAACTGCCAATACCAATATGTTTACATATGAAATTGCACCA
GTGTTTGTCCTCATGGAGCAAATAACACTTAAGAAGATGAGAGAGATAGTTGGATGGTCA
AGTAAAGATGGTGATGGGATATTTTCTCCTGGGGGAGCCATATCCAACATGTACAGCATC
ATGGCTGCTCGCTTCAAGTACTTCCCGGAAGTTAAGACCAAGGGTATGGCGGCTGTGCCC
AAGCTTGTCCTCTTCACCTCAGAACACAGTCACTATTCCATAAAGAAAGCTGGGGCTGCA
CTTGGCTTTGGAACCGACAACGTGATTTTGATAAAGTGCAATGAAAGGGGGAAGATAATT
CCAGCTGATTTAGAGACAAAAATTCTTGAAGCCAAGCAAAAGGGTTACGTCCCTCTCTAC
GTCAATGCAACTGCTGGCACCACTGTTTATGGCGCTTTTGATCCGATACAGGAGATTGCA
GATATATGTGAGAAATACAACCTTTGGCTGCATGTCGATGCTGCCTGGGGTGGCGGGCTG
CTCATGTCCCAGAAGCACCGCCATAAGCTCAGTGGCATCGAGAGGGCCAACTCTGTCACC
TGGAACCCTCACAAGATGATGGGTGTGCTGCTGCAGTGCTCTGCCATTCTTGTAAAAGAA
AAGGGTATCCTCCAAGGATGCAACCAGATGTGTGCGGGATACCTCTTCCAGCCGGACAAG
CAGTATGATGTCTCCTATGACACTGGGGACAAGGCCATTCAGTGTGGCCGCCACGTAGAC
ATCTTCAAGTTCTGGCTGATGTGGAAAGCAAAGGGTACAGTGGGCTTTGAAAATCAGATC
AACAAATGCTTGGAACTGGCTGAATACCTCTATGCCAAGATTAAAAACAGAGAAGAATTT
GAGATGGTTTTTGATGGTGAGCCTGAGCATACGAACGTCTGTTTCTGGTATATTCCACAA
AGCCTCAGGGGTGTTCCAGATAGCCCCGAACGACGGGAAAAGCTACACAGGGTGGCCCCA
AAGATCAAAGCCCTGATGATGGAATCTGGCACAACCATGGTTGGCTACCAGCCTCAGGGG
GACAAGGCCAACTTCTTCCGGATGGTCATCTCCAACCCAGCCGCTACCCAATCTGATATT
GACTTCCTCATTGAGGAGATAGAGAGGCTGGGCCAGGATCTGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 594 |
| Molecular Weight
| 66784.0 |
| Theoretical pI
| 7.18 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Glutamate decarboxylase 1
MASSTPSSSATSSNAGADPNTTNLRPTTYDTWCGVAHGCTRKLGLKICGFLQRTNSLEEK
SRLVSAFKERQSSKNLLSCENSDKDGRFRRTETDFSNLFARDLLPAKNGEEQTVQFLLEV
VDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSDHPESLEQILVDCRDTLKYGV
RTGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQITLKKMREIVGWS
SKDGDGIFSPGGAISNMYSIMAARFKYFPEVKTKGMAAVPKLVLFTSEHSHYSIKKAGAA
LGFGTDNVILIKCNERGKIIPADLETKILEAKQKGYVPLYVNATAGTTVYGAFDPIQEIA
DICEKYNLWLHVDAAWGGGLLMSQKHRHKLSGIERANSVTWNPHKMMGVLLQCSAILVKE
KGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQI
NKCLELAEYLYAKIKNREEFEMVFDGEPEHTNVCFWYIPQSLRGVPDSPERREKLHRVAP
KIKALMMESGTTMVGYQPQGDKANFFRMVISNPAATQSDIDFLIEEIERLGQDL
|
| External Links |
|---|
| GenBank ID Protein
| AAI20279.1 |
| UniProtKB/Swiss-Prot ID
| Q0VCA1 |
| UniProtKB/Swiss-Prot Entry Name
| DCE1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC120278 |
| GeneCard ID
| GAD1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
