| Identification |
|---|
| BMDB Protein ID
| BMDBP00864 |
| Secondary Accession Numbers
| |
| Name
| Farnesyl pyrophosphate synthase |
| Synonyms
|
Not Available
|
| Gene Name
| FDPS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Coenzyme transport and metabolism |
| Specific Function
| Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (By similarity). |
| Pathways
|
- Farnesyl diphosphate biosynthesis
- Farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.
- Geranyl diphosphate biosynthesis
- Geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1
- Isoprenoid biosynthesis
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| Not Available |
| SNPs
| FDPS |
| Gene Sequence
|
>1062 bp
ATGAATGGAGACCAGAAATTGGACGCTTACGCCCAAGAAAGGCAGGATTTCATCCAGCAC
TTCTCCCAGATTGTCAAGGTGCTGACTGAGGAGGACATTGGGCATCCAGAGATAGGAGAT
GCCATTACCCGACTCAAGGAGGTCCTGGAGTACAATGCCATCGGAGGCAAGTACAATCGG
GGTTTGACGGTGGTAATAACCTTCCGGGAGCTTGTGGAGCCTGGGAAACAAGATCCTGAC
AGTCTCCAGCGGGCCCTGACTGTGGGCTGGTGTGTGGAACTGCTCCAAGCCTTCTTCCTG
GTGTCAGATGACATTATGGACTCATCCCTCACCCGACGGGGGCAGACCTGCTGGTATCAG
AAGCCAGGCATAGGTTTGGATGCCATCAATGATGCTTTCCTTCTGGAATCATCCATCTAC
CGCCTGTTGAAGCTGTACTGTCGGGAGCAGCCCTATTACCTGGACCTGATCGAGCTCTTC
CTGCAGAGTTCTTATCAAACTGAGATCGGACAGACCTTGGACCTCATCACAGCTCCCCAG
GGCAACGTGGATCTTGGCAGATTCACAGAAAAGAGGTATAAGTCTATTGTCAAGTACAAG
ACAGCTTTCTACTCCTTTTACCTTCCTGTAGCTGCTGCCATGTATATGGCGGGCATTGAT
GGGGAGAAGGAGCATGCCCATGCCAAGAAGATCCTGCTAGAGATGGGAGAGTTCTTTCAG
ATTCAGGATGATTACCTCGATCTCTTTGGGGACCCCAGCATGACGGGTAAGATCGGCACA
GACATCCAGGACAACAAGTGCAGCTGGCTGGTGGTCCAGTGTCTGCAGCGGGCCTCTCCA
GAGCAGCGCCAAATCCTGCAGGAGAACTATGGGCAGAAGGAGGCTGAGAAGGTGGCCCGA
GTGAAGGCGCTCTACGAGGAGATGAATCTGTCGGCTGTGTACATGCAATACGAGGAAGAC
AGTTACAACCACATTATGGGTCTCATTGAGCAGTATGCTGCGCCCCTGCCCCCAGCCATC
TTCCTGGGGTTAGCACAAAAGATCTACAAGCGGAAAAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 353 |
| Molecular Weight
| 40510.0 |
| Theoretical pI
| 4.8 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Farnesyl pyrophosphate synthetase
MNGDQKLDAYAQERQDFIQHFSQIVKVLTEEDIGHPEIGDAITRLKEVLEYNAIGGKYNR
GLTVVITFRELVEPGKQDPDSLQRALTVGWCVELLQAFFLVSDDIMDSSLTRRGQTCWYQ
KPGIGLDAINDAFLLESSIYRLLKLYCREQPYYLDLIELFLQSSYQTEIGQTLDLITAPQ
GNVDLGRFTEKRYKSIVKYKTAFYSFYLPVAAAMYMAGIDGEKEHAHAKKILLEMGEFFQ
IQDDYLDLFGDPSMTGKIGTDIQDNKCSWLVVQCLQRASPEQRQILQENYGQKEAEKVAR
VKALYEEMNLSAVYMQYEEDSYNHIMGLIEQYAAPLPPAIFLGLAQKIYKRKK
|
| External Links |
|---|
| GenBank ID Protein
| AAL58886.1 |
| UniProtKB/Swiss-Prot ID
| Q8WMY2 |
| UniProtKB/Swiss-Prot Entry Name
| FPPS_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| AF461050 |
| GeneCard ID
| FDPS |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
