| Identification |
|---|
| BMDB Protein ID
| BMDBP00871 |
| Secondary Accession Numbers
| |
| Name
| Medium-chain specific acyl-CoA dehydrogenase, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| ACADM |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). |
| Pathways
|
- Lipid metabolism
- Mitochondrial fatty acid beta-oxidation
|
| Reactions
|
| Acrylyl-CoA + electron-transfer flavoprotein → Propionyl-CoA + Reduced electron-transfer flavoprotein |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| Not Available |
| SNPs
| ACADM |
| Gene Sequence
|
>1266 bp
ATGATCGCGCTGTTTAGGCGAAGCTGCGGGGTACTGAGAAGTCTTTCTCATTTTGACTGG
AGATCACAACATACAAAAACTGCCCTACAACGTGAGCCAGGATCAGGATTTAGTTTTGAA
TTCACTGAACAACAGAAAGAATTTCAAGCTACTGCTCGTAAATTTGCCAGGGAGGAAATA
ATTCCACTTGCTGCAGAATATGATAAAACCGGCGAGTACCCTGTCCCATTAATTAAAAGA
GCCTGGGAGCTTGGTTTAATGAATACACACATTCCAGAAAGTTGTGGAGGTCTTGGACTT
GGAACTTTTGATAGCTGTTTAATTTCTGAAGAATTGGCTTATGGATGTACAGGGGTTCAG
ACTGCTATTGAAGCAAATTCTCTAGGGCAAATGCCTGTTATTATTGCTGGAAATGATCAA
CAACAAAAGAAATATTTGGGGAGAATGACTGAGGAGCCATTAATGTGTGCCTATTGTGTA
ACAGAACCTGTAGCAGGCTCTGATGTAGCTGGTATAAAAACCAAAGCAGAAAAGAAAGGA
GATGAGTATATTATTAATGGTCAGAAGATGTGGATCACCAATGGAGGAAAAGCTAATTGG
TATTTTTTATTGGCTCGTTCTGATCCGGATCCTAAGGCTCCTGCTAGTAAAGCCTTTACT
GGCTTTATTGTGGAAGCAGACACCCCAGGAGTACAGATTGGAAGAAAGGAATTAAATATG
GGACAGCGATGTTCAGATACAAGAGGAATTGTCTTTGAAGATGTGAGAGTGCCCAAGGAA
AATGTTTTAATTGGTGAGGGAGCTGGTTTCAAAATTGCAATGGGAGCATTTGATAAAACC
AGACCACCAGTAGCAGCTGCTGCTGTGGGACTAGCACAGAGAGCTTTGGATGAAGCTACC
AAGTATGCCCTGGAGAGAAAAACTTTTGGAAAGCTGCTTATAGAGCACCAAGGAATATCA
TTTTTGCTGGCTGAAATGGCAATGAAAGTTGAACTAGCTAGATTGAGTTACCAGAGAGCA
GCTTGGGAAGTTGATTCTGGTCGCCGAAATACCTATTATGCCTCTATTGCAAAGGCATAT
GCTGGAGATATCGCAAATCAGTTAGCTTCTGATGCTGTTCAGATTTTTGGAGGCAATGGA
TTTAATACTGAATATCCTGTAGAAAAATTAATGAGAGATGCCAAGATCTATCAGATTTAT
GAAGGTACAGCACAAATTCAAAGGCTTATTATAGCCCGTGAACACATTGGCAGGTATAAG
AAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 421 |
| Molecular Weight
| 46573.0 |
| Theoretical pI
| 8.24 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
MIALFRRSCGVLRSLSHFDWRSQHTKTALQREPGSGFSFEFTEQQKEFQATARKFAREEI
IPLAAEYDKTGEYPVPLIKRAWELGLMNTHIPESCGGLGLGTFDSCLISEELAYGCTGVQ
TAIEANSLGQMPVIIAGNDQQQKKYLGRMTEEPLMCAYCVTEPVAGSDVAGIKTKAEKKG
DEYIINGQKMWITNGGKANWYFLLARSDPDPKAPASKAFTGFIVEADTPGVQIGRKELNM
GQRCSDTRGIVFEDVRVPKENVLIGEGAGFKIAMGAFDKTRPPVAAAAVGLAQRALDEAT
KYALERKTFGKLLIEHQGISFLLAEMAMKVELARLSYQRAAWEVDSGRRNTYYASIAKAY
AGDIANQLASDAVQIFGGNGFNTEYPVEKLMRDAKIYQIYEGTAQIQRLIIAREHIGRYK
K
|
| External Links |
|---|
| GenBank ID Protein
| ABS70460.1 |
| UniProtKB/Swiss-Prot ID
| Q3SZB4 |
| UniProtKB/Swiss-Prot Entry Name
| ACADM_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| EU009460 |
| GeneCard ID
| ACADM |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
