| Identification |
|---|
| BMDB Protein ID
| BMDBP00873 |
| Secondary Accession Numbers
| None |
| Name
| Hydroxyproline dehydrogenase |
| Synonyms
|
Not Available
|
| Gene Name
| PRODH2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis. |
| Pathways
|
- Amino-acid degradation
- L-glutamate from L-proline: step 1/2
- L-proline degradation into L-glutamate
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| Not Available |
| SNPs
| PRODH2 |
| Gene Sequence
|
>1386 bp
ATGCTTCAGGCCTGTCGTGTGCTCCGCTCCCGAGCTGGCCCCTCCCCAGGGAGCTGGCAG
CCCCTCAGCTTTGATGGTGGGGCCTTCCACCTCAAGAGCATAGGAGAACTGACCCGAGCT
TTGCTGGTGCTACGGCTGTGTGCCTGGCCGCCTCTGGTCACCCATGGCCTGGCGCTCCAA
GCCTGGTCTCAGCGACTCCTGGGCTCCCGGCTCTCCGGTGCGCTTCTCCGAGCATCCATC
TACGGGCAGTTTGTGGCTGGTGAGACCGCTGAGGAGGTGAGGAGCTGTGTCCTACAGCTC
CAGAACCTAGGCCTGCGGCCTCTGCTGGCAGTGCCCACTGAGGAGGAGCCAGACTCGGCT
GTCAAGACGGGTGAGGCCTGGTATGAAGGGAACCTCAGTGCGATGCTGCGATGCGTGGAC
CTGTCACGAGGCCTCCTGGAGACCCCTGACCCAACGGGAAATGCCCTGATGCAGCTGAAG
ATGACGGCGCTGATGAGCACTCGGCTCTGTAAGCAGCTCACCTCGTGGGTCCGAAGGCCA
GGGGATTCTTTGGAGCTGAGCCCCGAGAGGCTGGCAGAAGCCATGGACTCTGGACAGGAC
CTCCAGGTCTCCTGCCTCAACACCGAGCAAACACGACACCTCCAGGCCTCCCTGAGTCGT
TTGCACCGGGTGGTACAGCACGCCCGGGCCCAGCGCGTGAGGCTCCTGGTGGATGCCGAG
TACACCTCTCTGAACCCGGCACTCTCTCTGCTGGTGGCTGCCCTGGCCACGCGCTGGAAC
AGCTCCGGGGAAGGCGGGCCCTGGGTGTGGAACACTTACCAGGCCTATCTGAAGGACACC
TATGAGCGGCTGAGGTGGGACGCTGAGGCCGCAGACAGGGCTGGCCTGGCCTTTGGGGTG
AAGTTGGTACGAGGGGCGTATCTGGACAAGGAGAGAGAGACGGCCCGGCTCCAGGGAACC
GAAGATCCCACTCAGCCTGACTATGAGGCTACCAGTCAGAGTTACAGCCGCTGTCTGGAG
CTGATGCTGACCCAGGTGTCCCATCGTGGCCCCATGTGCCACCTCATGGTGGCTTCCCAC
AATGAGGACTCTGTCCGCCAGGCAACCAAGCGCATGTGGGAGCTGGGCATTCCTCCAGAT
GGGCCTGTCTGCTTTGGACAACTTCTGGGGATGTGTGACCATGTCTCCTTGGCACTGGGG
CAGGCTGGCTATGCTGTGTACAAGTCCATCCCCTATGGCTCTCTGGAGGAGGTGATCCCT
TACCTGATCCGGAGGGCCCAGGAGAACCGAAGTGTACTACGGGGTGCCCGCAGAGAACAG
GAGCTGCTCAGCCAAGAACTTCGACGGAGGCTGCTGGGGCGGGGCCTGAGGGTATCCCCC
CATTAG
|
| Protein Properties |
|---|
| Number of Residues
| 461 |
| Molecular Weight
| 51262.0 |
| Theoretical pI
| 8.4 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Probable proline dehydrogenase 2
MLQACRVLRSRAGPSPGSWQPLSFDGGAFHLKSIGELTRALLVLRLCAWPPLVTHGLALQ
AWSQRLLGSRLSGALLRASIYGQFVAGETAEEVRSCVLQLQNLGLRPLLAVPTEEEPDSA
VKTGEAWYEGNLSAMLRCVDLSRGLLETPDPTGNALMQLKMTALMSTRLCKQLTSWVRRP
GDSLELSPERLAEAMDSGQDLQVSCLNTEQTRHLQASLSRLHRVVQHARAQRVRLLVDAE
YTSLNPALSLLVAALATRWNSSGEGGPWVWNTYQAYLKDTYERLRWDAEAADRAGLAFGV
KLVRGAYLDKERETARLQGTEDPTQPDYEATSQSYSRCLELMLTQVSHRGPMCHLMVASH
NEDSVRQATKRMWELGIPPDGPVCFGQLLGMCDHVSLALGQAGYAVYKSIPYGSLEEVIP
YLIRRAQENRSVLRGARREQELLSQELRRRLLGRGLRVSPH
|
| External Links |
|---|
| GenBank ID Protein
| AAI49683.1 |
| UniProtKB/Swiss-Prot ID
| A6QQ74 |
| UniProtKB/Swiss-Prot Entry Name
| HYPDH_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC149682 |
| GeneCard ID
| PRODH2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
