Showing Protein Hydroxyproline dehydrogenase (BMDBP00873)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00873 |
| Secondary Accession Numbers | None |
| Name | Hydroxyproline dehydrogenase |
| Synonyms | Not Available |
| Gene Name | PRODH2 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Amino acid transport and metabolism |
| Specific Function | Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis. |
| Pathways |
|
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 18 |
| Locus | Not Available |
| SNPs | PRODH2 |
| Gene Sequence |
>1386 bp ATGCTTCAGGCCTGTCGTGTGCTCCGCTCCCGAGCTGGCCCCTCCCCAGGGAGCTGGCAG CCCCTCAGCTTTGATGGTGGGGCCTTCCACCTCAAGAGCATAGGAGAACTGACCCGAGCT TTGCTGGTGCTACGGCTGTGTGCCTGGCCGCCTCTGGTCACCCATGGCCTGGCGCTCCAA GCCTGGTCTCAGCGACTCCTGGGCTCCCGGCTCTCCGGTGCGCTTCTCCGAGCATCCATC TACGGGCAGTTTGTGGCTGGTGAGACCGCTGAGGAGGTGAGGAGCTGTGTCCTACAGCTC CAGAACCTAGGCCTGCGGCCTCTGCTGGCAGTGCCCACTGAGGAGGAGCCAGACTCGGCT GTCAAGACGGGTGAGGCCTGGTATGAAGGGAACCTCAGTGCGATGCTGCGATGCGTGGAC CTGTCACGAGGCCTCCTGGAGACCCCTGACCCAACGGGAAATGCCCTGATGCAGCTGAAG ATGACGGCGCTGATGAGCACTCGGCTCTGTAAGCAGCTCACCTCGTGGGTCCGAAGGCCA GGGGATTCTTTGGAGCTGAGCCCCGAGAGGCTGGCAGAAGCCATGGACTCTGGACAGGAC CTCCAGGTCTCCTGCCTCAACACCGAGCAAACACGACACCTCCAGGCCTCCCTGAGTCGT TTGCACCGGGTGGTACAGCACGCCCGGGCCCAGCGCGTGAGGCTCCTGGTGGATGCCGAG TACACCTCTCTGAACCCGGCACTCTCTCTGCTGGTGGCTGCCCTGGCCACGCGCTGGAAC AGCTCCGGGGAAGGCGGGCCCTGGGTGTGGAACACTTACCAGGCCTATCTGAAGGACACC TATGAGCGGCTGAGGTGGGACGCTGAGGCCGCAGACAGGGCTGGCCTGGCCTTTGGGGTG AAGTTGGTACGAGGGGCGTATCTGGACAAGGAGAGAGAGACGGCCCGGCTCCAGGGAACC GAAGATCCCACTCAGCCTGACTATGAGGCTACCAGTCAGAGTTACAGCCGCTGTCTGGAG CTGATGCTGACCCAGGTGTCCCATCGTGGCCCCATGTGCCACCTCATGGTGGCTTCCCAC AATGAGGACTCTGTCCGCCAGGCAACCAAGCGCATGTGGGAGCTGGGCATTCCTCCAGAT GGGCCTGTCTGCTTTGGACAACTTCTGGGGATGTGTGACCATGTCTCCTTGGCACTGGGG CAGGCTGGCTATGCTGTGTACAAGTCCATCCCCTATGGCTCTCTGGAGGAGGTGATCCCT TACCTGATCCGGAGGGCCCAGGAGAACCGAAGTGTACTACGGGGTGCCCGCAGAGAACAG GAGCTGCTCAGCCAAGAACTTCGACGGAGGCTGCTGGGGCGGGGCCTGAGGGTATCCCCC CATTAG |
| Protein Properties | |
| Number of Residues | 461 |
| Molecular Weight | 51262.0 |
| Theoretical pI | 8.4 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Probable proline dehydrogenase 2 MLQACRVLRSRAGPSPGSWQPLSFDGGAFHLKSIGELTRALLVLRLCAWPPLVTHGLALQ AWSQRLLGSRLSGALLRASIYGQFVAGETAEEVRSCVLQLQNLGLRPLLAVPTEEEPDSA VKTGEAWYEGNLSAMLRCVDLSRGLLETPDPTGNALMQLKMTALMSTRLCKQLTSWVRRP GDSLELSPERLAEAMDSGQDLQVSCLNTEQTRHLQASLSRLHRVVQHARAQRVRLLVDAE YTSLNPALSLLVAALATRWNSSGEGGPWVWNTYQAYLKDTYERLRWDAEAADRAGLAFGV KLVRGAYLDKERETARLQGTEDPTQPDYEATSQSYSRCLELMLTQVSHRGPMCHLMVASH NEDSVRQATKRMWELGIPPDGPVCFGQLLGMCDHVSLALGQAGYAVYKSIPYGSLEEVIP YLIRRAQENRSVLRGARREQELLSQELRRRLLGRGLRVSPH |
| External Links | |
| GenBank ID Protein | AAI49683.1 |
| UniProtKB/Swiss-Prot ID | A6QQ74 |
| UniProtKB/Swiss-Prot Entry Name | HYPDH_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC149682 |
| GeneCard ID | PRODH2 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |