Identification
BMDB Protein ID BMDBP00877
Secondary Accession Numbers
  • BMDBP03074
Name Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
Synonyms Not Available
Gene Name COQ6
Protein Type Enzyme
Biological Properties
General Function Coenzyme transport and metabolism
Specific Function FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
Pathways
  • Cofactor biosynthesis
  • Ubiquinone Biosynthesis
Reactions
2-Hexaprenyl-6-methoxyphenol + Oxygen → 2-Hexaprenyl-6-methoxy-1,4-benzoquinone + Water details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 10
Locus Not Available
SNPs COQ6
Gene Sequence
>1410 bp
ATGGCGGCCCAGTTGGCTAGAGTCCGGTGGGGCACTGTCTTTGCCGCTGCCCAGAAGGGC
CCGCGGGTCTCCTGCCGGAGGTGGGCTGGCGCCTCGGCGGACAACGTGTACGATGTGGTG
GTGTCGGGGGGAGGCCTGGTAGGCGCCGCTATGGCTTGTGCCTTAGGACATGATATTCAC
TTTTGTGACAAGAAAATACTGTTGTTAGAAGCAGGTCCAAAGAAAGTGCTGGAGAAATTG
CCAGAAACTTACAGCAACAGAGTCAGCTCCATCTCCCCTGGCTCTGCAACCCTTCTCAGT
AGTTTTGGTGCCTGGGACCACATCTGCAACATGCGATGCAGAGCCTTTCGGCGAATGCAG
GTGTGGGATGCCTGCTCAGAGGCCCTGATAATGTTCGATAAGGATAATTTAGATGACATG
GGCTATATAGTGGAGAACGATGTCATCATGCATGCTCTCACTAAGCAGCTGGAGGCTGTG
TCAGACCAAGTGACCGTTCTCTACAAGAGCAAAGCAGTCAGCTATACCTGGCCTTATCCG
TTTTCCATGGCAGACTCCAGCCCTTGGGTTCATATTACCCTAGGTGATGGCAGAACCCTC
CAGACCAAATTGTTGATTGGTGCAGACGGTCACAACTCAGGAGTGCGGCAGGCTGCAGGA
ATCCGGAATGTTAGCTGGAACTATGACCAATCCGCTGTTGTGGCTACTCTGCATTTATCA
GAGGCCACCGAAAACAATGTAGCTTGGCAGAGATTTCTCCCCTCTGGGCCCATTGCTCTG
CTTCCGCTCTCAGACACTTTGAGTTCCTTGGTTTGGTCCACATCCCATGAACATGCAGCA
GAGCTGGTCAGCATGGAAGAGGAGGAGTTTGTGGATGCCATTAACTCCGCCTTTTGGAGT
GATGTGAACCACACAGACTTCATCGACTCAGCTGGCTCCATGCTGCAGTCCGCAGTTGCC
TTTCTGAAGCCCACTAGAGTCTCAGCTCGCCAGCTGCCCCCCAGTGTTGCCAGGGTGGAC
GCCAAAAGCCGAGTCCTGTTTCCTCTTGGGTTGGGACACGCTGCCGAGTATGTCCGGCCT
CGGCTGGCCCTCATTGGGGATGCAGCCCACAGGGTCCATCCACTTGCAGGACAAGGTGTC
AACATGGGCTTTGGGGATATCTCCAGTTTGCTCCATCACCTCAGTACTGCAGCCTTCAAT
GGCAAAGACTTAGGCTCCATGAGCCACCTCACAAGTTATGAAACAGACAGACAGCGTCAC
AACACCGCTCTTCTGGCTGCTACGGACCTACTGAAGAGGCTCTATTCCACCAGGGCCACC
CTCGTCGTGCTGCTCAGGACCTGGGGCTTGCAGGCTACAAATGCAGTGTATCCACTCAAA
GAACAGATCATGGCCTTTGCAAGCAAATGA
Protein Properties
Number of Residues 469
Molecular Weight 51072.0
Theoretical pI 7.48
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions Not Available
Protein Sequence
>Ubiquinone biosynthesis monooxygenase COQ6
MAAQLARVRWGTVFAAAQKGPRVSCRRWAGASADNVYDVVVSGGGLVGAAMACALGHDIH
FCDKKILLLEAGPKKVLEKLPETYSNRVSSISPGSATLLSSFGAWDHICNMRCRAFRRMQ
VWDACSEALIMFDKDNLDDMGYIVENDVIMHALTKQLEAVSDQVTVLYKSKAVSYTWPYP
FSMADSSPWVHITLGDGRTLQTKLLIGADGHNSGVRQAAGIRNVSWNYDQSAVVATLHLS
EATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHEHAAELVSMEEEEFVDAINSAFWS
DVNHTDFIDSAGSMLQSAVAFLKPTRVSARQLPPSVARVDAKSRVLFPLGLGHAAEYVRP
RLALIGDAAHRVHPLAGQGVNMGFGDISSLLHHLSTAAFNGKDLGSMSHLTSYETDRQRH
NTALLAATDLLKRLYSTRATLVVLLRTWGLQATNAVYPLKEQIMAFASK
GenBank ID Protein AAI12595.1
UniProtKB/Swiss-Prot ID Q2KIL4
UniProtKB/Swiss-Prot Entry Name COQ6_BOVIN
PDB IDs Not Available
GenBank Gene ID DAAA02029604
GeneCard ID COQ6
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available