| Identification |
|---|
| BMDB Protein ID
| BMDBP00877 |
| Secondary Accession Numbers
| |
| Name
| Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| COQ6 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Coenzyme transport and metabolism |
| Specific Function
| FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. |
| Pathways
|
- Cofactor biosynthesis
- Ubiquinone Biosynthesis
|
| Reactions
|
| 2-Hexaprenyl-6-methoxyphenol + Oxygen → 2-Hexaprenyl-6-methoxy-1,4-benzoquinone + Water |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| Not Available |
| SNPs
| COQ6 |
| Gene Sequence
|
>1410 bp
ATGGCGGCCCAGTTGGCTAGAGTCCGGTGGGGCACTGTCTTTGCCGCTGCCCAGAAGGGC
CCGCGGGTCTCCTGCCGGAGGTGGGCTGGCGCCTCGGCGGACAACGTGTACGATGTGGTG
GTGTCGGGGGGAGGCCTGGTAGGCGCCGCTATGGCTTGTGCCTTAGGACATGATATTCAC
TTTTGTGACAAGAAAATACTGTTGTTAGAAGCAGGTCCAAAGAAAGTGCTGGAGAAATTG
CCAGAAACTTACAGCAACAGAGTCAGCTCCATCTCCCCTGGCTCTGCAACCCTTCTCAGT
AGTTTTGGTGCCTGGGACCACATCTGCAACATGCGATGCAGAGCCTTTCGGCGAATGCAG
GTGTGGGATGCCTGCTCAGAGGCCCTGATAATGTTCGATAAGGATAATTTAGATGACATG
GGCTATATAGTGGAGAACGATGTCATCATGCATGCTCTCACTAAGCAGCTGGAGGCTGTG
TCAGACCAAGTGACCGTTCTCTACAAGAGCAAAGCAGTCAGCTATACCTGGCCTTATCCG
TTTTCCATGGCAGACTCCAGCCCTTGGGTTCATATTACCCTAGGTGATGGCAGAACCCTC
CAGACCAAATTGTTGATTGGTGCAGACGGTCACAACTCAGGAGTGCGGCAGGCTGCAGGA
ATCCGGAATGTTAGCTGGAACTATGACCAATCCGCTGTTGTGGCTACTCTGCATTTATCA
GAGGCCACCGAAAACAATGTAGCTTGGCAGAGATTTCTCCCCTCTGGGCCCATTGCTCTG
CTTCCGCTCTCAGACACTTTGAGTTCCTTGGTTTGGTCCACATCCCATGAACATGCAGCA
GAGCTGGTCAGCATGGAAGAGGAGGAGTTTGTGGATGCCATTAACTCCGCCTTTTGGAGT
GATGTGAACCACACAGACTTCATCGACTCAGCTGGCTCCATGCTGCAGTCCGCAGTTGCC
TTTCTGAAGCCCACTAGAGTCTCAGCTCGCCAGCTGCCCCCCAGTGTTGCCAGGGTGGAC
GCCAAAAGCCGAGTCCTGTTTCCTCTTGGGTTGGGACACGCTGCCGAGTATGTCCGGCCT
CGGCTGGCCCTCATTGGGGATGCAGCCCACAGGGTCCATCCACTTGCAGGACAAGGTGTC
AACATGGGCTTTGGGGATATCTCCAGTTTGCTCCATCACCTCAGTACTGCAGCCTTCAAT
GGCAAAGACTTAGGCTCCATGAGCCACCTCACAAGTTATGAAACAGACAGACAGCGTCAC
AACACCGCTCTTCTGGCTGCTACGGACCTACTGAAGAGGCTCTATTCCACCAGGGCCACC
CTCGTCGTGCTGCTCAGGACCTGGGGCTTGCAGGCTACAAATGCAGTGTATCCACTCAAA
GAACAGATCATGGCCTTTGCAAGCAAATGA
|
| Protein Properties |
|---|
| Number of Residues
| 469 |
| Molecular Weight
| 51072.0 |
| Theoretical pI
| 7.48 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Ubiquinone biosynthesis monooxygenase COQ6
MAAQLARVRWGTVFAAAQKGPRVSCRRWAGASADNVYDVVVSGGGLVGAAMACALGHDIH
FCDKKILLLEAGPKKVLEKLPETYSNRVSSISPGSATLLSSFGAWDHICNMRCRAFRRMQ
VWDACSEALIMFDKDNLDDMGYIVENDVIMHALTKQLEAVSDQVTVLYKSKAVSYTWPYP
FSMADSSPWVHITLGDGRTLQTKLLIGADGHNSGVRQAAGIRNVSWNYDQSAVVATLHLS
EATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHEHAAELVSMEEEEFVDAINSAFWS
DVNHTDFIDSAGSMLQSAVAFLKPTRVSARQLPPSVARVDAKSRVLFPLGLGHAAEYVRP
RLALIGDAAHRVHPLAGQGVNMGFGDISSLLHHLSTAAFNGKDLGSMSHLTSYETDRQRH
NTALLAATDLLKRLYSTRATLVVLLRTWGLQATNAVYPLKEQIMAFASK
|
| External Links |
|---|
| GenBank ID Protein
| AAI12595.1 |
| UniProtKB/Swiss-Prot ID
| Q2KIL4 |
| UniProtKB/Swiss-Prot Entry Name
| COQ6_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| DAAA02029604 |
| GeneCard ID
| COQ6 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
