| Identification |
|---|
| BMDB Protein ID
| BMDBP00883 |
| Secondary Accession Numbers
| None |
| Name
| L-gulonolactone oxidase |
| Synonyms
|
Not Available
|
| Gene Name
| GULO |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Oxidizes L-gulono-1,4-lactone to hydrogen peroxide and L-xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate. |
| Pathways
|
- Cofactor biosynthesis
- L-ascorbate biosynthesis via UDP-alpha-D-glucuronate pathway
- L-ascorbate from UDP-alpha-D-glucuronate: step 4/4
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| Not Available |
| SNPs
| GULO |
| Gene Sequence
|
>1323 bp
ATGGTCCACGGGTACAAGGGGGTCAAATTCCAAAACTGGGCAAGGACCTATGGCTGTTGC
CCGGAGATGTACTTTCAGCCCACGTCCGTGGAGGAGGTCAGAGAGGTGCTGGCCCTGGCC
AGGCAGCAGAACAAGCGGGTGAAGGTGGTGGGCGGTGGCCACTCGCCCTCAGACATCGCC
TGCACTGACGGCTTCATGATCCACATGGGCAAGATGAACCGCGTCCTCAAGGTGGACACA
GAGAAGAAGCAGGTGACCGTGGAGGCCGGCATCCTCCTAGCTGACCTGCACCCCCAGCTG
GACAAGCACGGCCTGGCTTTGTCCAACCTGGGAGCTGTGTCAGACGTGACCGCAGGTGGC
GTCATCGGGTCTGGAACCCACAACACGGGGATCAAGCACGGCATCCTGGCCACACAAGTG
GTGGCACTGACCCTGCTGACAGCCAATGGGACCATTCTCGAGTGTTCAGAGTCCAGCAAT
GCGGAGGTGTTCCAGGCTGCGCGCGTGCACTTGGGCTGCCTCGGAGTCATCCTCACAGTC
ACACTGCAGTGTGTGCCCCAGTTCCACTTGCAGGAGACCACCTTCCCCTCAACCTTGAAA
GAGGTTCTTGACAACCTGGACAGTCACCTGAAGAAATCCGAATACTTCCGCTTTCTCTGG
TTCCCACACAGCGAGAATGTCAGTGTAATCTACCAGGACCACACCAACAAGCCGCCCTCC
TCTTCAGCCAACTGGTTCTGGGACTACGCTATTGGATTCTACTTACTGGAGTTCCTACTC
TGGATCAGCACCTTCCTGCCAGGCCTTGTGGGCTGGATCAATCGCTTTTTCTTCTGGCTC
CTGTTCAATGGGAAGAAGGAAAACTGCAACCTCAGCCACAAGATCTTCACCTACGAGTGC
CGCTTCAAGCAGCATGTCCAGGACTGGGCCATCCCCAGAGAGAAGACCAAAGAGGCCCTG
CTGGAGCTGAAGGCCATGCTGGAGGCGAACCCCAAGGTAGTGGCCCACTACCCCGTGGAG
GTACGCTTCACTCGCGGGGACGACATCCTGCTGAGCCCCTGCTTCCAGCGCGACAGCTGC
TACATGAACATCATCATGTACAGGCCCTATGGCAAGGACGTACCGCGGCTGGACTACTGG
CTGGCCTATGAGACCATCATGAAGAAGGTGGGAGGCAGGCCCCACTGGGCCAAGGCCCAC
AACTGCACCCGGAAGGACTTTGAGAAAATGTACCCGGCCTTCCAGAGGTTCTGTGCCATC
CGAGAAAAGCTGGACCCCACGGGGATGTTCCTGAACGCCTATCTGGAGAAAGTGTTCTAC
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 440 |
| Molecular Weight
| 50282.0 |
| Theoretical pI
| 8.41 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>L-gulonolactone oxidase
MVHGYKGVKFQNWARTYGCCPEMYFQPTSVEEVREVLALARQQNKRVKVVGGGHSPSDIA
CTDGFMIHMGKMNRVLKVDTEKKQVTVEAGILLADLHPQLDKHGLALSNLGAVSDVTAGG
VIGSGTHNTGIKHGILATQVVALTLLTANGTILECSESSNAEVFQAARVHLGCLGVILTV
TLQCVPQFHLQETTFPSTLKEVLDNLDSHLKKSEYFRFLWFPHSENVSVIYQDHTNKPPS
SSANWFWDYAIGFYLLEFLLWISTFLPGLVGWINRFFFWLLFNGKKENCNLSHKIFTYEC
RFKQHVQDWAIPREKTKEALLELKAMLEANPKVVAHYPVEVRFTRGDDILLSPCFQRDSC
YMNIIMYRPYGKDVPRLDYWLAYETIMKKVGGRPHWAKAHNCTRKDFEKMYPAFQRFCAI
REKLDPTGMFLNAYLEKVFY
|
| External Links |
|---|
| GenBank ID Protein
| AAI02937.1 |
| UniProtKB/Swiss-Prot ID
| Q3ZC33 |
| UniProtKB/Swiss-Prot Entry Name
| GGLO_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC102936 |
| GeneCard ID
| GULO |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
