| Identification |
|---|
| BMDB Protein ID
| BMDBP00889 |
| Secondary Accession Numbers
| None |
| Name
| Ferroptosis suppressor protein 1 |
| Synonyms
|
Not Available
|
| Gene Name
| AIFM2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| A NAD(P)H-dependent oxidoreductase involved in cellular oxidative stress response. At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis. Cooperates with GPX4 to suppress phospholipid peroxidation and ferroptosis. This anti-ferroptotic function is independent of cellular glutathione levels. May play a role in mitochondrial stress signaling. Upon oxidative stress, associates with the lipid peroxidation end product 4-hydroxy-2-nonenal (HNE) forming a lipid adduct devoid of oxidoreductase activity, which then translocates from mitochondria into the nucleus triggering DNA damage and cell death. Capable of DNA binding in a non-sequence specific way. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 28 |
| Locus
| Not Available |
| SNPs
| AIFM2 |
| Gene Sequence
|
>1122 bp
ATGGGGTCCCAGGTCTCGATGGACGCGGGAGCCGTGCATGTTGTGATTGTGGGCGGGGGC
TTTGGTGGCATCGCTGCCGCCAGCCAGCTGCAGGCACTGAACATCCCGTTTGTGCTGGTG
GACATGAAGGACTCCTTCCACCACAACGTGGCAGCCCTCCGGGCCTCCGTGGAGAGTGGG
TTTGCCAAAAAGACATTCATTTCCTACTCGGTGACCTTCAAGGAAAACTTCAGACAGGGC
CTGGTGGTCGAGATAGACCTGAAGAATCAGACGGTGCTGCTGGAGGATGGCCAGGCCCTA
CCCTTTTCACATCTCATCCTGGCCACGGGCAGCACTGGGCTCTTCCCGGGCAAGTTTAAC
CAGGTTTCCAGCCAGCAGATGGCCATCCAGGCCTATGAGGACATGGTGACGCAGGTCCAG
CGCTCACAGTCCATTGTGGTGGTGGGAGGAGGCTCTGCAGGAGTGGAGATGGCAGCAGAG
ATTAAAACGGAATACCCTGAGAAAGAGGTCACTCTCATTCACTCCAAGATGGCCCTCGCA
GACACAGAGCTCCTGCCCTGTGTCCGGCAGGAAGTGAAGGAGATCCTGCTCCGGAAAGGC
GTGCAGCTGCTGCTGAGCGAGCGAGTGAGCAACCTGGAGGCACTGCCTGTCAACGAGCGT
CGCGAGTGCATCAAGGTGCAGACGGACAAAGGCACGGAGGTAGATGCCAACCTGGTGATT
GTCTGCAACGGTATCAAGATCAACAGTGCAGCCTACCGCAGCGCGTTTGGTGATCGGCTA
GCCAGCAACGGCGCTCTGAGAGTAAACGAGTACCTCCAGGTGGAAGGTTACAGCCACATC
TATGCCATTGGAGACTGCGCCGACGTGAGGGAGCCCAAGATGGCCTATCATGCCAGCCTC
CACGCCAACGTCGCCGTGGCCAATATTGTCAACTCCATGAAACAGAGGCCCCTCAAAACC
TACAAGCCAGGTTCACTGACGTTCCTCCTGGCCATGGGGAGAAATGACGGCGTGGGCCAG
ATCAGCGGCTTCTACGTGGGGCGGCTTATGGTTCGGCTGGCCAAGAGCCGGGACCTGTTG
GTCTCCACGAGCTGGAAAACCATGAAACAGTCTCCACCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 373 |
| Molecular Weight
| 40477.0 |
| Theoretical pI
| 8.57 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Apoptosis-inducing factor 2
MGSQVSMDAGAVHVVIVGGGFGGIAAASQLQALNIPFVLVDMKDSFHHNVAALRASVESG
FAKKTFISYSVTFKENFRQGLVVEIDLKNQTVLLEDGQALPFSHLILATGSTGLFPGKFN
QVSSQQMAIQAYEDMVTQVQRSQSIVVVGGGSAGVEMAAEIKTEYPEKEVTLIHSKMALA
DTELLPCVRQEVKEILLRKGVQLLLSERVSNLEALPVNERRECIKVQTDKGTEVDANLVI
VCNGIKINSAAYRSAFGDRLASNGALRVNEYLQVEGYSHIYAIGDCADVREPKMAYHASL
HANVAVANIVNSMKQRPLKTYKPGSLTFLLAMGRNDGVGQISGFYVGRLMVRLAKSRDLL
VSTSWKTMKQSPP
|
| External Links |
|---|
| GenBank ID Protein
| AAI42172.1 |
| UniProtKB/Swiss-Prot ID
| A5PJM4 |
| UniProtKB/Swiss-Prot Entry Name
| FSP1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC142171 |
| GeneCard ID
| AIFM2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
