Showing Protein Ferroptosis suppressor protein 1 (BMDBP00889)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00889 |
| Secondary Accession Numbers | None |
| Name | Ferroptosis suppressor protein 1 |
| Synonyms | Not Available |
| Gene Name | AIFM2 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Energy production and conversion |
| Specific Function | A NAD(P)H-dependent oxidoreductase involved in cellular oxidative stress response. At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis. Cooperates with GPX4 to suppress phospholipid peroxidation and ferroptosis. This anti-ferroptotic function is independent of cellular glutathione levels. May play a role in mitochondrial stress signaling. Upon oxidative stress, associates with the lipid peroxidation end product 4-hydroxy-2-nonenal (HNE) forming a lipid adduct devoid of oxidoreductase activity, which then translocates from mitochondria into the nucleus triggering DNA damage and cell death. Capable of DNA binding in a non-sequence specific way. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 28 |
| Locus | Not Available |
| SNPs | AIFM2 |
| Gene Sequence |
>1122 bp ATGGGGTCCCAGGTCTCGATGGACGCGGGAGCCGTGCATGTTGTGATTGTGGGCGGGGGC TTTGGTGGCATCGCTGCCGCCAGCCAGCTGCAGGCACTGAACATCCCGTTTGTGCTGGTG GACATGAAGGACTCCTTCCACCACAACGTGGCAGCCCTCCGGGCCTCCGTGGAGAGTGGG TTTGCCAAAAAGACATTCATTTCCTACTCGGTGACCTTCAAGGAAAACTTCAGACAGGGC CTGGTGGTCGAGATAGACCTGAAGAATCAGACGGTGCTGCTGGAGGATGGCCAGGCCCTA CCCTTTTCACATCTCATCCTGGCCACGGGCAGCACTGGGCTCTTCCCGGGCAAGTTTAAC CAGGTTTCCAGCCAGCAGATGGCCATCCAGGCCTATGAGGACATGGTGACGCAGGTCCAG CGCTCACAGTCCATTGTGGTGGTGGGAGGAGGCTCTGCAGGAGTGGAGATGGCAGCAGAG ATTAAAACGGAATACCCTGAGAAAGAGGTCACTCTCATTCACTCCAAGATGGCCCTCGCA GACACAGAGCTCCTGCCCTGTGTCCGGCAGGAAGTGAAGGAGATCCTGCTCCGGAAAGGC GTGCAGCTGCTGCTGAGCGAGCGAGTGAGCAACCTGGAGGCACTGCCTGTCAACGAGCGT CGCGAGTGCATCAAGGTGCAGACGGACAAAGGCACGGAGGTAGATGCCAACCTGGTGATT GTCTGCAACGGTATCAAGATCAACAGTGCAGCCTACCGCAGCGCGTTTGGTGATCGGCTA GCCAGCAACGGCGCTCTGAGAGTAAACGAGTACCTCCAGGTGGAAGGTTACAGCCACATC TATGCCATTGGAGACTGCGCCGACGTGAGGGAGCCCAAGATGGCCTATCATGCCAGCCTC CACGCCAACGTCGCCGTGGCCAATATTGTCAACTCCATGAAACAGAGGCCCCTCAAAACC TACAAGCCAGGTTCACTGACGTTCCTCCTGGCCATGGGGAGAAATGACGGCGTGGGCCAG ATCAGCGGCTTCTACGTGGGGCGGCTTATGGTTCGGCTGGCCAAGAGCCGGGACCTGTTG GTCTCCACGAGCTGGAAAACCATGAAACAGTCTCCACCCTGA |
| Protein Properties | |
| Number of Residues | 373 |
| Molecular Weight | 40477.0 |
| Theoretical pI | 8.57 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions |
|
| Protein Sequence |
>Apoptosis-inducing factor 2 MGSQVSMDAGAVHVVIVGGGFGGIAAASQLQALNIPFVLVDMKDSFHHNVAALRASVESG FAKKTFISYSVTFKENFRQGLVVEIDLKNQTVLLEDGQALPFSHLILATGSTGLFPGKFN QVSSQQMAIQAYEDMVTQVQRSQSIVVVGGGSAGVEMAAEIKTEYPEKEVTLIHSKMALA DTELLPCVRQEVKEILLRKGVQLLLSERVSNLEALPVNERRECIKVQTDKGTEVDANLVI VCNGIKINSAAYRSAFGDRLASNGALRVNEYLQVEGYSHIYAIGDCADVREPKMAYHASL HANVAVANIVNSMKQRPLKTYKPGSLTFLLAMGRNDGVGQISGFYVGRLMVRLAKSRDLL VSTSWKTMKQSPP |
| External Links | |
| GenBank ID Protein | AAI42172.1 |
| UniProtKB/Swiss-Prot ID | A5PJM4 |
| UniProtKB/Swiss-Prot Entry Name | FSP1_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC142171 |
| GeneCard ID | AIFM2 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |