| Identification |
|---|
| BMDB Protein ID
| BMDBP00890 |
| Secondary Accession Numbers
| |
| Name
| Amine oxidase [flavin-containing] A |
| Synonyms
|
Not Available
|
| Gene Name
| MAOA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. |
| Pathways
|
Not Available
|
| Reactions
|
| 1-Methylhistamine + Water + Oxygen → Methylimidazole acetaldehyde + Ammonia + Hydrogen peroxide |
details
|
| Norepinephrine + Water + Oxygen → 3,4-Dihydroxymandelaldehyde + Ammonia + Hydrogen peroxide |
details
|
| Epinephrine + Water + Oxygen → 3,4-Dihydroxymandelaldehyde + Methylamine + Hydrogen peroxide |
details
|
| Normetanephrine + Water + Oxygen → 3-Methoxy-4-hydroxyphenylglycolaldehyde + Ammonia + Hydrogen peroxide |
details
|
| Metanephrine + Water + Oxygen → 3-Methoxy-4-hydroxyphenylglycolaldehyde + Ammonia + Hydrogen peroxide |
details
|
| Dopamine + Water + Oxygen → 3,4-Dihydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxide |
details
|
| 3-Methoxytyramine + Water + Oxygen → Homovanillin + Hydrogen peroxide + Ammonia |
details
|
| Aminoacetone + Oxygen + Water → Ammonia + Hydrogen peroxide + Pyruvaldehyde |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| X |
| Locus
| Not Available |
| SNPs
| MAOA |
| Gene Sequence
|
>1584 bp
ATGGAGAGTCTGCAGAAGACGAGTGACGCGGGCCAGATGTTCGACGTAGTCGTGATAGGA
GGCGGCATCTCAGGATTATCTGCTGCGAAACTCTTAGCCGAACATGAAGTTAATGTTTTG
GTTTTAGAAGCCCGGGAGAGAGTTGGAGGAAGAACATACACAGTGAGGAATGAACATGTT
GACTACGTAGATGTTGGCGGTGCTTATGTAGGCCCGACCCAGAATAGGATCTTACGGTTA
TCTAAGCAACTGGGTTTAGAAACTTACAAAGTGAATGTAAACGAGCGTCTTGTTCATTAT
GTCAAGGGAAAAACTTATCCATTTCGGGGTGCCTTCCCTCCAGTATGGAATCCCATTGCT
TATCTGGATTACAACAACCTCTGGCGGACCATGGATAACATGGGAAAAGAGATTCCAGCT
GATGCACCATGGGAGGCCCCACATGCAGTGGAATGGGATAAGATGACTATGAAAGATCTC
ATCGAAAAAATCTGCTGGACAAAGACTGCTCGGCAGTTTGCATCTCTCTTTGTGAATATC
AATGTGACCTCTGAACCCCATGAGGTGTCTGCCCTGTGGTTCTTGTGGTACGTGAAACAA
TGTGGGGGCACAACTCGGATATTCTCCATTACCAACGGTGGCCAGGAACGGAAGTTTGTA
GGTGGATCTGGTCAAGTAAGCGAACGGATAATGCAACTCCTAGGGGACAGGGTGAAACTG
AGGAGCCCTGTCACCTATGTTGACCAGTCAAGTGAAAACATCACCGTAGAGACCCTGAAT
CGTGAACTTTATGAGTGCCGGTATGTCATTAGTGCCATCCCACCAACTTTGACTGCCAAG
ATACACTTTAGACCAGAGCTTCCATCAGAGCGAAACCAGCTGATACAGCGTCTTCCAATG
GGGGCTGTCATTAAGTGCATGATGTATTACAAGGAGGCCTTTTGGAAGAAAAAGGATTAC
TGTGGCTGTATGATCATCGAAGATGAGGAAGCTCCAATTTCAATAACACTGGATGATACC
AAGCCAGATGGATCACTGCCTGCTATCATGGGCTTCATCCTCGCTCGAAAAGCTGACCGC
CTCGCTAAAGTGCATAAAGATATAAGGAAAAGAAAAATCTGTGAACGGTACGCCAAAGTG
CTAGGATCTCAAGAAGCTTTACATCCAGTGCACTATGAAGAGAAGAACTGGTGTCAGGAG
CAGTACTCCGGAGGCTGCTACACTGCCTACTTCCCCCCGGGGATCATGACTCAATACGGA
AGGGTTATTCGCCAACCTGTAGGCAGGATTTACTTTGCTGGCACGGAAACTGCCACACAA
TGGAGCGGTTATATGGAAGGAGCAGTAGAGGCTGGTGAACGGGCAGCTAGAGAGGTTTTG
AATGCTTTGGGGAAGCTGTCTGCCAAAGATATCTGGATCCAAGAACCTGAAGCTGAAGAT
GTTCCAGCTGTAGAGATCACCCCCAGCTTCTGGGAGAGAAACCTGCCTTCCGTATCAGGC
CTGCTGAAGATTGTTGGGTTTTCCACATCGATAACTGCCCTGTGGTTTGTGATGTACAGA
TTCAGGCTGCTAAGCCGATCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 527 |
| Molecular Weight
| 59758.0 |
| Theoretical pI
| 8.12 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Amine oxidase [flavin-containing] A
MESLQKTSDAGQMFDVVVIGGGISGLSAAKLLAEHEVNVLVLEARERVGGRTYTVRNEHV
DYVDVGGAYVGPTQNRILRLSKQLGLETYKVNVNERLVHYVKGKTYPFRGAFPPVWNPIA
YLDYNNLWRTMDNMGKEIPADAPWEAPHAVEWDKMTMKDLIEKICWTKTARQFASLFVNI
NVTSEPHEVSALWFLWYVKQCGGTTRIFSITNGGQERKFVGGSGQVSERIMQLLGDRVKL
RSPVTYVDQSSENITVETLNRELYECRYVISAIPPTLTAKIHFRPELPSERNQLIQRLPM
GAVIKCMMYYKEAFWKKKDYCGCMIIEDEEAPISITLDDTKPDGSLPAIMGFILARKADR
LAKVHKDIRKRKICELYAKVLGSQEALHPVHYEEKNWCQEQYSGGCYTAYFPPGIMTQYG
RVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKLSAKDIWIQEPEAED
VPAVEITPSFWERNLPSVSGLLKIVGFSTSITALWFVMYRFRLLSRS
|
| External Links |
|---|
| GenBank ID Protein
| CAA33632.1 |
| UniProtKB/Swiss-Prot ID
| P21398 |
| UniProtKB/Swiss-Prot Entry Name
| AOFA_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| X15609 |
| GeneCard ID
| MAOA |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
