| Identification |
|---|
| BMDB Protein ID
| BMDBP00904 |
| Secondary Accession Numbers
| None |
| Name
| ERO1-like protein alpha |
| Synonyms
|
Not Available
|
| Gene Name
| ERO1A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in electron carrier activity |
| Specific Function
| Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1 (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| Not Available |
| SNPs
| ERO1A |
| Gene Sequence
|
>1407 bp
ATGGGCCGCCGCTGGGGCTTCCTGATCGGCTTCTTGGTCGCCGTGGGGTTGCTGGGCTTG
GGCCACGGCGAGCAGCAGCCCTCAGAGACGGCGGCGCAGAGGTGCTTCTGCCAGGTTAGT
GGTTACTTGGATGATTGTACCTGTGATGTTGAAACCATTGATAAATTTAATAACTACAGG
CTTTTCCCAAGACTTCAAAAACTCCTGGAAAGTGACTACTTTAGATATTACAAGGTAAAC
CTGAAAAGGCCATGTCCTTTCTGGAATGATATCAACCAGTGTGGAAGAAGGGATTGTGCC
GTCAAGCCTTGTCACTCAGATGAAGTTCCTGATGGAATTAAGTCTGCAAGCTACAAGTAT
TCTGAAGAAGCCAATAATCTCATTGAAGAATGTGAGCAAGCTGAACGACTTGGAGCTGTG
GATGAATCTCTGAGTGAGGAAACACAGAAGGCTGTTCTTCAGTGGACCAAGCATGATGAT
TCCTCAGACAACTTCTGTGAAGTTGATGATATACAGTCTCCTGATGCTGAGTATGTCGAT
TTGCTCCTTAATCCCGAGCGCTACACGGGTTACAAAGGACCAGATGCTTGGAAGATATGG
AATGTCATCTATGAAGAAAACTGTTTTAAGCCACAGACAATTAAAAGACCTTTAAATCCT
TTGGCTTCTGGTCAAGGTAAAAGTGAAGAGAATACTTTTTACAGTTGGCTAGAAGGTCTC
TGTGTAGAGAAAAGAGCATTCTACAGACTTATATCTGGCCTCCATGCAAGCATTAATGTG
CATTTGAGTGCACGGTATCTTCTACAAGATACGTGGTTGGAAAAAAAATGGGGACACAAC
ATTACAGAATTTCAACAGCGATTTGATGGAATATTAACTGAAGGAGAAGGTCCACGAAGG
CTTAAGAACTTGTATTTTCTCTACTTAATAGAATTAAGGGCTTTGTCTAAAGTGGTTCCA
TTCTTTGAGCGCCCAGATTTTCAACTCTTCACTGGAAATAAAGATCAGGATGCAGAAAAC
AAAATGTTACTTCTGGAAATACTTCATGAAATCAAGTCATTTCCTTTGCATTTTGATGAG
AATTCATTTTTTGCTGGGAATAAAAAAGAAGCAAACAAACTAAAGGAGGATTTTCGACTG
CATTTTAGAAATATTTCAAGAATCATGGATTGTGTTGGTTGTTTGAAATGTCGACTGTGG
GGAAAGCTTCAGACTCAGGGTTTGGGCACTGCTCTGAAGATCTTGTTTTCTGAGAAATTG
ATTGCAAATATGCCAGAAAGTGGACCCAGTTATGAATTCCATCTAACCAGACAAGAAATA
GTATCATTATTTAATGCATTTGGAAGAATTTCAACAAGTGTGAAAGAATTAGAAAACTTC
AGGAACTTGTTACAAAATATTCATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 468 |
| Molecular Weight
| 54297.0 |
| Theoretical pI
| 6.0 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>ERO1-like protein alpha
MGRRWGFLIGFLVAVGLLGLGHGEQQPSETAAQRCFCQVSGYLDDCTCDVETIDKFNNYR
LFPRLQKLLESDYFRYYKVNLKRPCPFWNDINQCGRRDCAVKPCHSDEVPDGIKSASYKY
SEEANNLIEECEQAERLGAVDESLSEETQKAVLQWTKHDDSSDNFCEVDDIQSPDAEYVD
LLLNPERYTGYKGPDAWKIWNVIYEENCFKPQTIKRPLNPLASGQGKSEENTFYSWLEGL
CVEKRAFYRLISGLHASINVHLSARYLLQDTWLEKKWGHNITEFQQRFDGILTEGEGPRR
LKNLYFLYLIELRALSKVVPFFERPDFQLFTGNKDQDAENKMLLLEILHEIKSFPLHFDE
NSFFAGNKKEANKLKEDFRLHFRNISRIMDCVGCLKCRLWGKLQTQGLGTALKILFSEKL
IANMPESGPSYEFHLTRQEIVSLFNAFGRISTSVKELENFRNLLQNIH
|
| External Links |
|---|
| GenBank ID Protein
| AAI42180.1 |
| UniProtKB/Swiss-Prot ID
| A5PJN2 |
| UniProtKB/Swiss-Prot Entry Name
| ERO1A_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC142179 |
| GeneCard ID
| ERO1A |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
