Showing Protein Methylenetetrahydrofolate reductase (BMDBP00906)
| Identification | |||
|---|---|---|---|
| BMDB Protein ID | BMDBP00906 | ||
| Secondary Accession Numbers | None | ||
| Name | Methylenetetrahydrofolate reductase | ||
| Synonyms | Not Available | ||
| Gene Name | MTHFR | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Amino acid transport and metabolism | ||
| Specific Function | Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. | ||
| Pathways |
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| Reactions |
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| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 16 | ||
| Locus | Not Available | ||
| SNPs | MTHFR | ||
| Gene Sequence |
>1968 bp ATGGTGAACGAACCCAGAGGGAACGGCAGCCCCGGCCCCCGCTGGGAGGGCAGCAGCAGC GGCAGCGAGAGCTCAAGGACAAGTTCAAGGTGCTCCACGCCGGGGTTGGACCCCGAGCGA TGCGAGAGACTCCGGGAGAAGATGAAGCGGAAGATGGACTCTGGAGACAAGTGGTTCTCC CTAGAGTTCTTCCCTCCCCGAACTGCCCAGGGTGCTGTCAATCTCATCTCCAGGTTTGAC CGGATGGGAGCGGGTGGCCCCCTCTTTGTAGACGTGACCTGGCACCCAGCCGGGGATCCT GGCTCCGACAAGGAGACCTCGTCCATGGTGATTGCCAGCACTGCCGTGAACTACTGCGGC CTCGAGACAATCCTGCACATGACCTGCTGCCATCAGAGCCGTGAAGAGATCACGGGCCAC CTGAACAAAGCCAAGCAGCTGGGCCTGAAGAACATCCTGGCGCTGAGGGGAGACCCCATA GGTGACCAATGGGAAGAGGAGGAAGGAGGCTTCAACTATGCTACGGACTTGGTGAAGCAC ATCCGAAACGAGTTTGGTGACTACTTTGACGTCTGTGTGGCAGGTTACCCCAAAGGCCAC CCTGAAGGAGAGAGCTTTGAGGCTGATCTGAAGCACCTGAAGGAGAAGGTGGCTGCAGGA GCCGACTTCATCATCACCCAGCTATTCTTTGAGGCTGAAACATTCTTCCGCTTTGTGAAG GCTTGCTCCGAGATAGGCATTACCTGCCCCGTCCTCCCCGGCATCTTCCCAATTCAGGGC TACCACTCCCTCCGGCAGCTGGTGAAACTGTCCAAACTGGAGGTGCCACAGCAGATCAAG GATGTGATCGAGCCCATCAAAGACAATGATGCTGCCATCCGCAACTATGGCATCGAGCAG GCCGTGAGCCTGTGCCAGGAGCTGCTGGCCAGTGGCTTGGTTCCAGGCCTCCACTTCTAC ACCCTCAACCGCGAGGTGGCCACCATCGAGGTGCTGAAGCGCCTGGGGCTTTGGATTGAG GACCCTAGGCGTCCCCTGCCCTGGGCCCTCAGTGCCCACCCCAAGCGCCGGGTGGAGGAT GTCCGGCCCATCTTCTGGGCCTCGAGACCAAAGAGTTACATTTACCGTACGCAGGAGTGG GACGAGTTCCCCAATGGCCGCTGGGGCAATTCCTCCTCTCCGGCCTTTGGGGAGCTGAAG GACTACTACCTCTTCTACCTAAAGAGCAAGTCCCCGAAGGAGGAGCTGCTCAAGATGTGG GGGGAGGAGCTGACCAGTGAGGAAAGCGTCTTCCAAGTCTTTGCCCACCACCTCTCGGGA GAGCCCAACCAGAATGGCTACAAAGTGACTTGCCTGCCCTGGAATGATGAGCCCCTGGCA GCCGAGACCAGCCTGATGAAGGAGGAGCTGCTGAGAGTGAACCGGCGAGGCATCCTCACC ATCAACTCCCAGCCCAACATCAACGGGAAGCCGTCCTCTGACCCCATCGTGGGCTGGGGC CCCAGTGGGGGCTATGTCTTCCAGAAGGCCTACTTAGAGTTCTTCACTTCCCGAGAAACG GTGGAGGCGCTTTTGCAGGTGCTGAAGAAGTATGAACTCCGGGTGAATTACCACATCGTG GATGTGAAGGGTGAAAATATCACCAACGCCCCTGAGCTGCAACCCAACGCGGTCACCTGG GGCATCTTCCCTGGCCGAGAGATCATCCAGCCCACAGTGGTGGACCCGGTCAGCTTCATG TTCTGGAAGGATGAGGCCTTCGCGCTGTGGATTGAGCAGTGGGGCAAGCTGTATGAGGAG GAGTCCCCCTCCCGCATGATCATCCAGTACATCCACGACAACTACTTCCTGGTCAACCTG GTGGACAACGAGTTTCCGCTGGACAACTGCCTGTGGCAGGTGGTGGAAGACACGTTTGAG CTTCTCAGCAGGCCCCCCCAAGACAAGAGGGAGACAGAGGCGCTGTGA |
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| Protein Properties | |||
| Number of Residues | 655 | ||
| Molecular Weight | 74485.0 | ||
| Theoretical pI | 5.1 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
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| Transmembrane Regions | Not Available | ||
| Protein Sequence |
>Methylenetetrahydrofolate reductase MVNEPRGNGSPGPRWEGSSSGSESSRTSSRCSTPGLDPERCERLREKMKRKMDSGDKWFS LEFFPPRTAQGAVNLISRFDRMGAGGPLFVDVTWHPAGDPGSDKETSSMVIASTAVNYCG LETILHMTCCHQSREEITGHLNKAKQLGLKNILALRGDPIGDQWEEEEGGFNYATDLVKH IRNEFGDYFDVCVAGYPKGHPEGESFEADLKHLKEKVAAGADFIITQLFFEAETFFRFVK ACSEIGITCPVLPGIFPIQGYHSLRQLVKLSKLEVPQQIKDVIEPIKDNDAAIRNYGIEQ AVSLCQELLASGLVPGLHFYTLNREVATIEVLKRLGLWIEDPRRPLPWALSAHPKRRVED VRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPKEELLKMW GEELTSEESVFQVFAHHLSGEPNQNGYKVTCLPWNDEPLAAETSLMKEELLRVNRRGILT INSQPNINGKPSSDPIVGWGPSGGYVFQKAYLEFFTSRETVEALLQVLKKYELRVNYHIV DVKGENITNAPELQPNAVTWGIFPGREIIQPTVVDPVSFMFWKDEAFALWIEQWGKLYEE ESPSRMIIQYIHDNYFLVNLVDNEFPLDNCLWQVVEDTFELLSRPPQDKRETEAL |
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| External Links | |||
| GenBank ID Protein | AAW39033.1 | ||
| UniProtKB/Swiss-Prot ID | Q5I598 | ||
| UniProtKB/Swiss-Prot Entry Name | MTHR_BOVIN | ||
| PDB IDs | Not Available | ||
| GenBank Gene ID | AY854631 | ||
| GeneCard ID | MTHFR | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||