Showing Protein Hexokinase-1 (BMDBP00912)
| Identification | |||||||||||||||||||
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| BMDB Protein ID | BMDBP00912 | ||||||||||||||||||
| Secondary Accession Numbers | None | ||||||||||||||||||
| Name | Hexokinase-1 | ||||||||||||||||||
| Synonyms | Not Available | ||||||||||||||||||
| Gene Name | HK1 | ||||||||||||||||||
| Protein Type | Enzyme | ||||||||||||||||||
| Biological Properties | |||||||||||||||||||
| General Function | Involved in ATP binding | ||||||||||||||||||
| Specific Function | Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan. When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (By similarity). | ||||||||||||||||||
| Pathways |
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| Reactions |
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| GO Classification | Not Available | ||||||||||||||||||
| Cellular Location | Not Available | ||||||||||||||||||
| Gene Properties | |||||||||||||||||||
| Chromosome Location | 28 | ||||||||||||||||||
| Locus | Not Available | ||||||||||||||||||
| SNPs | HK1 | ||||||||||||||||||
| Gene Sequence | Not Available | ||||||||||||||||||
| Protein Properties | |||||||||||||||||||
| Number of Residues | 918 | ||||||||||||||||||
| Molecular Weight | 103064.0 | ||||||||||||||||||
| Theoretical pI | 7.04 | ||||||||||||||||||
| Pfam Domain Function | Not Available | ||||||||||||||||||
| Signals |
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| Transmembrane Regions | Not Available | ||||||||||||||||||
| Protein Sequence |
>Hexokinase-1 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLLDIMNRFKKEMKNGLSRDFNPTAT VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEQNRPVHMESEVYDTPENIMH GSGSQLFDHVLECLGDFMEKKKIKDKKLPVGFTFSFPCRQSKIDQAILITWTKRFKARGA EGNYVVKLLDKAIKKRGDYDANIVAVVNDTVGTMIDCGYDDQHCEVGLIIGTGTNACYME ELRQIDFGWGDDGRMCINTEWGDLGDDGSLEDIRKEFDREFRRGSLNPGKQRFEKMVSGR YMEDVVRLVLVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKDKEGLHNAKEILTRLG VERSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKSTPRLRTTVRVDGSLYKTH PQYSRRFHKTLRRLVPDSDVRFLLSESGTGKGAAMVTAVAYRLAEQHRQIEETLAHFRLS KQTLMEVKKRLRTEMEMGLRKETNSNATVNMLPSFLRSIPDGTEDGDFLALDLGGTNFRV LLVKIRSGKKSTVEMHNKIYRIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAVKRREEFDLDVVAVVNDTVG TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGNQRQMCINMEWGAFGDNGCSDD IRTDFDKVVDEYSLNSGNQRFENMISGIYLGEIVRNILIDFTKKGFLFRGQISEPLKTRG IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAA VVEKIRENRGLDRLNVTVGVDGTLYKLHPQFSRIMHQTVKELSPKCNVSFLLSEDGSGKG AALITAVGVRLRGESAIS |
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| GenBank ID Protein | AAA51661.1 | ||||||||||||||||||
| UniProtKB/Swiss-Prot ID | P27595 | ||||||||||||||||||
| UniProtKB/Swiss-Prot Entry Name | HXK1_BOVIN | ||||||||||||||||||
| PDB IDs | |||||||||||||||||||
| GenBank Gene ID | M65140 | ||||||||||||||||||
| GeneCard ID | HK1 | ||||||||||||||||||
| GenAtlas ID | Not Available | ||||||||||||||||||
| HGNC ID | Not Available | ||||||||||||||||||
| References | |||||||||||||||||||
| General References | Not Available | ||||||||||||||||||