| Identification |
|---|
| BMDB Protein ID
| BMDBP00912 |
| Secondary Accession Numbers
| None |
| Name
| Hexokinase-1 |
| Synonyms
|
Not Available
|
| Gene Name
| HK1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan. When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (By similarity). |
| Pathways
|
- Amino Sugar Metabolism
- Carbohydrate metabolism
- Fructose and Mannose Degradation
- Galactose Metabolism
- Gluconeogenesis
- Glycolysis
- Hexose metabolism
- Nucleotide Sugars Metabolism
- Starch and Sucrose Metabolism
- Trehalose Degradation
- Warburg Effect
|
| Reactions
|
| D-Fructose + Adenosine triphosphate → Fructose 6-phosphate + ADP |
details
|
| Glucosamine + Adenosine triphosphate → Glucosamine 6-phosphate + ADP |
details
|
| D-Mannose + Adenosine triphosphate → Mannose 6-phosphate + ADP |
details
|
| Adenosine triphosphate + Alpha-D-Glucose → ADP + Glucose 6-phosphate |
details
|
| D-Glucose + Adenosine triphosphate → Glucose 6-phosphate + ADP |
details
|
| Alpha-D-Glucose + Adenosine triphosphate → Glucose 6-phosphate + ADP |
details
|
| Adenosine triphosphate + Beta-D-Glucose → ADP + Beta-D-Glucose 6-phosphate |
details
|
| Adenosine triphosphate + D-Fructose → ADP + Beta-D-Fructose 6-phosphate |
details
|
| Beta-D-Glucose + Adenosine triphosphate → Beta-D-Glucose 6-phosphate + ADP |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 28 |
| Locus
| Not Available |
| SNPs
| HK1 |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 918 |
| Molecular Weight
| 103064.0 |
| Theoretical pI
| 7.04 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Hexokinase-1
MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLLDIMNRFKKEMKNGLSRDFNPTAT
VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEQNRPVHMESEVYDTPENIMH
GSGSQLFDHVLECLGDFMEKKKIKDKKLPVGFTFSFPCRQSKIDQAILITWTKRFKARGA
EGNYVVKLLDKAIKKRGDYDANIVAVVNDTVGTMIDCGYDDQHCEVGLIIGTGTNACYME
ELRQIDFGWGDDGRMCINTEWGDLGDDGSLEDIRKEFDREFRRGSLNPGKQRFEKMVSGR
YMEDVVRLVLVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKDKEGLHNAKEILTRLG
VERSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKSTPRLRTTVRVDGSLYKTH
PQYSRRFHKTLRRLVPDSDVRFLLSESGTGKGAAMVTAVAYRLAEQHRQIEETLAHFRLS
KQTLMEVKKRLRTEMEMGLRKETNSNATVNMLPSFLRSIPDGTEDGDFLALDLGGTNFRV
LLVKIRSGKKSTVEMHNKIYRIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF
TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAVKRREEFDLDVVAVVNDTVG
TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGNQRQMCINMEWGAFGDNGCSDD
IRTDFDKVVDEYSLNSGNQRFENMISGIYLGEIVRNILIDFTKKGFLFRGQISEPLKTRG
IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAA
VVEKIRENRGLDRLNVTVGVDGTLYKLHPQFSRIMHQTVKELSPKCNVSFLLSEDGSGKG
AALITAVGVRLRGESAIS
|
| External Links |
|---|
| GenBank ID Protein
| AAA51661.1 |
| UniProtKB/Swiss-Prot ID
| P27595 |
| UniProtKB/Swiss-Prot Entry Name
| HXK1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| M65140 |
| GeneCard ID
| HK1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
