Identification |
BMDB Protein ID
| BMDBP00918 |
Secondary Accession Numbers
| None |
Name
| Kininogen-1 |
Synonyms
|
Not Available
|
Gene Name
| KNG1 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Inorganic ion transport and metabolism |
Specific Function
| (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting. |
Pathways
|
Not Available
|
Reactions
| Not Available |
GO Classification
|
Not Available
|
Cellular Location
|
Not Available
|
Gene Properties |
Chromosome Location
| 1 |
Locus
| Not Available |
SNPs
| KNG1 |
Gene Sequence
|
>1866 bp
ATGAAATTAATCACCATCCTTTTCCTTTGTTCCAGGCTGCTACCAAGTTTAACCCAAGAG
TCCTCTCAAGAAATCGACTGCAACGACCAGGATGTATTTAAAGCTGTGGACGCTGCTCTG
ACAAAATACAACAGTGAAAACAAGAGTGGCAACCAGTTTGTATTGTACCGCATAACCGAG
GTCGCCAGAATGGATAATCCTGACACATTTTATTCCTTGAAGTACCAAATCAAGGAGGGC
GACTGTCCTTTTCAAAGTAACAAAACTTGGCAGGACTGTGACTACAAGGACTCTGCACAA
GCTGCCACAGGAGAGTGCACAGCGACCGTGGCCAAGAGAGGGAATATGAAGTTCTCCGTG
GCTATCCAGACCTGCCTGATCACTCCAGCCGAGGGCCCCGTGGTGACAGCCCAGTATGAG
TGCCTTGGCTGTGTGCATCCCATATCTACCAAGAGCCCCGACTTGGAGCCTGTTCTGAGA
TATGCCATCCAATATTTTAACAACAACACCAGTCATTCCCACCTCTTTGATCTGAAAGAA
GTAAAAAGAGCCCAAAGACAGGTGGTGTCTGGATGGAACTATGAAGTTAATTACTCAATT
GCACAAACTAATTGTTCCAAGGAGGAATTTTCATTCTTAACTCCAGACTGCAAGTCCCTT
TCAAGTGGTGATACTGGTGAATGTACAGATAAAGCACATGTAGATGTCAAGCTAAGAATT
TCTTCCTTCTCGCAGAAATGTGACCTTTATCCAGTGAAGGATTTTGTACAACCACCCACC
AGGCTTTGTGCCGGCTGCCCCAAACCTATACCTGTTGACAGCCCAGACCTGGAGGAGCCT
CTGAGCCATTCCATCGCAAAGCTTAATGCAGAGCATGATGGAGCCTTCTATTTCAAGATT
GACACTGTGAAAAAAGCAACAGTACAGGTGGTAGCTGGATTGAAGTATTCTATTGTGTTC
ATAGCAAGGGAAACCACATGTTCTAAGGGAAGTAATGAAGAGCTGACCAAGAGTTGTGAG
ATCAATATACATGGTCAAATTCTACACTGTGATGCTAATGTCTATGTGGTGCCTTGGGAG
GAAAAAGTTTACCCTACTGTCAACTGTCAACCACTTGGACAGACCTCACTCATGAAAAGG
CCTCCGGGTTTTTCACCTTTCCGATCAGTTCAAGTGATGAAAACTGAAGGAAGCACAACT
GTAAGTCTACCCCACTCTGCCATGTCACCTGTACAAGATGAAGAGCGGGATTCAGGAAAA
GAACAAGGACCCACTCATGGGCATGGCTGGGACCATGGAAAGCAAATAAAATTACATGGC
CTTGGCCTTGGCCATAAACATAAGCATGACCAAGGTCATGGGCACCATGGAAGTCATGGT
CTTGGCCATGGACATCAAAAGCAACATGGTCTTGGCCATGGACATAAGCATGGTCATGGC
CACGGAAAACATAAAAACAAAGGAAAAAACAATGGAAAGCATTATGATTGGAGGACACCC
TATTTGGCAAGTTCTTATGAAGATAGCACTACATCCTCTGCACAGACGCAAGAGAAGACA
GAAGAGACAACACTCTCTTCCCTAGCCCAGCCAGGTGTAGCCATTACCTTTCCTGACTTT
CAGGACTCAGATCTCATTGCAACTGTGATGCCTAATACACTACCACCTCACACAGAGAGT
GATGATGACTGGATCCCTGACATCCAGACAGAGCCAAATAGCCTTGCATTTAAATTGATT
TCAGACTTTCCAGAAACAACCTCCCCCAAATGTCCTAGTCGCCCCTGGAAGCCAGTTAAT
GGAGTGAATCCAACTGTGGAAATGAAAGAGTCTCATGATTTTGATCTTGTTGATGCTCTT
CTTTAA
|
Protein Properties |
Number of Residues
| 621 |
Molecular Weight
| 68890.0 |
Theoretical pI
| 6.61 |
Pfam Domain Function
|
Not Available |
Signals
|
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Kininogen-1
MKLITILFLCSRLLPSLTQESSQEIDCNDQDVFKAVDAALTKYNSENKSGNQFVLYRITE
VARMDNPDTFYSLKYQIKEGDCPFQSNKTWQDCDYKDSAQAATGECTATVAKRGNMKFSV
AIQTCLITPAEGPVVTAQYECLGCVHPISTKSPDLEPVLRYAIQYFNNNTSHSHLFDLKE
VKRAQRQVVSGWNYEVNYSIAQTNCSKEEFSFLTPDCKSLSSGDTGECTDKAHVDVKLRI
SSFSQKCDLYPVKDFVQPPTRLCAGCPKPIPVDSPDLEEPLSHSIAKLNAEHDGAFYFKI
DTVKKATVQVVAGLKYSIVFIARETTCSKGSNEELTKSCEINIHGQILHCDANVYVVPWE
EKVYPTVNCQPLGQTSLMKRPPGFSPFRSVQVMKTEGSTTVSLPHSAMSPVQDEERDSGK
EQGPTHGHGWDHGKQIKLHGLGLGHKHKHDQGHGHHGSHGLGHGHQKQHGLGHGHKHGHG
HGKHKNKGKNNGKHYDWRTPYLASSYEDSTTSSAQTQEKTEETTLSSLAQPGVAITFPDF
QDSDLIATVMPNTLPPHTESDDDWIPDIQTEPNSLAFKLISDFPETTSPKCPSRPWKPVN
GVNPTVEMKESHDFDLVDALL
|
External Links |
GenBank ID Protein
| CAA24735.1 |
UniProtKB/Swiss-Prot ID
| P01044 |
UniProtKB/Swiss-Prot Entry Name
| KNG1_BOVIN |
PDB IDs
|
Not Available |
GenBank Gene ID
| V01491 |
GeneCard ID
| KNG1 |
GenAtlas ID
| Not Available |
HGNC ID
| Not Available |
References |
General References
| Not Available |