Showing Protein Kininogen-1 (BMDBP00918)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00918 |
| Secondary Accession Numbers | None |
| Name | Kininogen-1 |
| Synonyms | Not Available |
| Gene Name | KNG1 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Inorganic ion transport and metabolism |
| Specific Function | (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 1 |
| Locus | Not Available |
| SNPs | KNG1 |
| Gene Sequence |
>1866 bp ATGAAATTAATCACCATCCTTTTCCTTTGTTCCAGGCTGCTACCAAGTTTAACCCAAGAG TCCTCTCAAGAAATCGACTGCAACGACCAGGATGTATTTAAAGCTGTGGACGCTGCTCTG ACAAAATACAACAGTGAAAACAAGAGTGGCAACCAGTTTGTATTGTACCGCATAACCGAG GTCGCCAGAATGGATAATCCTGACACATTTTATTCCTTGAAGTACCAAATCAAGGAGGGC GACTGTCCTTTTCAAAGTAACAAAACTTGGCAGGACTGTGACTACAAGGACTCTGCACAA GCTGCCACAGGAGAGTGCACAGCGACCGTGGCCAAGAGAGGGAATATGAAGTTCTCCGTG GCTATCCAGACCTGCCTGATCACTCCAGCCGAGGGCCCCGTGGTGACAGCCCAGTATGAG TGCCTTGGCTGTGTGCATCCCATATCTACCAAGAGCCCCGACTTGGAGCCTGTTCTGAGA TATGCCATCCAATATTTTAACAACAACACCAGTCATTCCCACCTCTTTGATCTGAAAGAA GTAAAAAGAGCCCAAAGACAGGTGGTGTCTGGATGGAACTATGAAGTTAATTACTCAATT GCACAAACTAATTGTTCCAAGGAGGAATTTTCATTCTTAACTCCAGACTGCAAGTCCCTT TCAAGTGGTGATACTGGTGAATGTACAGATAAAGCACATGTAGATGTCAAGCTAAGAATT TCTTCCTTCTCGCAGAAATGTGACCTTTATCCAGTGAAGGATTTTGTACAACCACCCACC AGGCTTTGTGCCGGCTGCCCCAAACCTATACCTGTTGACAGCCCAGACCTGGAGGAGCCT CTGAGCCATTCCATCGCAAAGCTTAATGCAGAGCATGATGGAGCCTTCTATTTCAAGATT GACACTGTGAAAAAAGCAACAGTACAGGTGGTAGCTGGATTGAAGTATTCTATTGTGTTC ATAGCAAGGGAAACCACATGTTCTAAGGGAAGTAATGAAGAGCTGACCAAGAGTTGTGAG ATCAATATACATGGTCAAATTCTACACTGTGATGCTAATGTCTATGTGGTGCCTTGGGAG GAAAAAGTTTACCCTACTGTCAACTGTCAACCACTTGGACAGACCTCACTCATGAAAAGG CCTCCGGGTTTTTCACCTTTCCGATCAGTTCAAGTGATGAAAACTGAAGGAAGCACAACT GTAAGTCTACCCCACTCTGCCATGTCACCTGTACAAGATGAAGAGCGGGATTCAGGAAAA GAACAAGGACCCACTCATGGGCATGGCTGGGACCATGGAAAGCAAATAAAATTACATGGC CTTGGCCTTGGCCATAAACATAAGCATGACCAAGGTCATGGGCACCATGGAAGTCATGGT CTTGGCCATGGACATCAAAAGCAACATGGTCTTGGCCATGGACATAAGCATGGTCATGGC CACGGAAAACATAAAAACAAAGGAAAAAACAATGGAAAGCATTATGATTGGAGGACACCC TATTTGGCAAGTTCTTATGAAGATAGCACTACATCCTCTGCACAGACGCAAGAGAAGACA GAAGAGACAACACTCTCTTCCCTAGCCCAGCCAGGTGTAGCCATTACCTTTCCTGACTTT CAGGACTCAGATCTCATTGCAACTGTGATGCCTAATACACTACCACCTCACACAGAGAGT GATGATGACTGGATCCCTGACATCCAGACAGAGCCAAATAGCCTTGCATTTAAATTGATT TCAGACTTTCCAGAAACAACCTCCCCCAAATGTCCTAGTCGCCCCTGGAAGCCAGTTAAT GGAGTGAATCCAACTGTGGAAATGAAAGAGTCTCATGATTTTGATCTTGTTGATGCTCTT CTTTAA |
| Protein Properties | |
| Number of Residues | 621 |
| Molecular Weight | 68890.0 |
| Theoretical pI | 6.61 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Kininogen-1 MKLITILFLCSRLLPSLTQESSQEIDCNDQDVFKAVDAALTKYNSENKSGNQFVLYRITE VARMDNPDTFYSLKYQIKEGDCPFQSNKTWQDCDYKDSAQAATGECTATVAKRGNMKFSV AIQTCLITPAEGPVVTAQYECLGCVHPISTKSPDLEPVLRYAIQYFNNNTSHSHLFDLKE VKRAQRQVVSGWNYEVNYSIAQTNCSKEEFSFLTPDCKSLSSGDTGECTDKAHVDVKLRI SSFSQKCDLYPVKDFVQPPTRLCAGCPKPIPVDSPDLEEPLSHSIAKLNAEHDGAFYFKI DTVKKATVQVVAGLKYSIVFIARETTCSKGSNEELTKSCEINIHGQILHCDANVYVVPWE EKVYPTVNCQPLGQTSLMKRPPGFSPFRSVQVMKTEGSTTVSLPHSAMSPVQDEERDSGK EQGPTHGHGWDHGKQIKLHGLGLGHKHKHDQGHGHHGSHGLGHGHQKQHGLGHGHKHGHG HGKHKNKGKNNGKHYDWRTPYLASSYEDSTTSSAQTQEKTEETTLSSLAQPGVAITFPDF QDSDLIATVMPNTLPPHTESDDDWIPDIQTEPNSLAFKLISDFPETTSPKCPSRPWKPVN GVNPTVEMKESHDFDLVDALL |
| External Links | |
| GenBank ID Protein | CAA24735.1 |
| UniProtKB/Swiss-Prot ID | P01044 |
| UniProtKB/Swiss-Prot Entry Name | KNG1_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | V01491 |
| GeneCard ID | KNG1 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |