Identification
BMDB Protein ID BMDBP00918
Secondary Accession Numbers None
Name Kininogen-1
Synonyms Not Available
Gene Name KNG1
Protein Type Enzyme
Biological Properties
General Function Inorganic ion transport and metabolism
Specific Function (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 1
Locus Not Available
SNPs KNG1
Gene Sequence
>1866 bp
ATGAAATTAATCACCATCCTTTTCCTTTGTTCCAGGCTGCTACCAAGTTTAACCCAAGAG
TCCTCTCAAGAAATCGACTGCAACGACCAGGATGTATTTAAAGCTGTGGACGCTGCTCTG
ACAAAATACAACAGTGAAAACAAGAGTGGCAACCAGTTTGTATTGTACCGCATAACCGAG
GTCGCCAGAATGGATAATCCTGACACATTTTATTCCTTGAAGTACCAAATCAAGGAGGGC
GACTGTCCTTTTCAAAGTAACAAAACTTGGCAGGACTGTGACTACAAGGACTCTGCACAA
GCTGCCACAGGAGAGTGCACAGCGACCGTGGCCAAGAGAGGGAATATGAAGTTCTCCGTG
GCTATCCAGACCTGCCTGATCACTCCAGCCGAGGGCCCCGTGGTGACAGCCCAGTATGAG
TGCCTTGGCTGTGTGCATCCCATATCTACCAAGAGCCCCGACTTGGAGCCTGTTCTGAGA
TATGCCATCCAATATTTTAACAACAACACCAGTCATTCCCACCTCTTTGATCTGAAAGAA
GTAAAAAGAGCCCAAAGACAGGTGGTGTCTGGATGGAACTATGAAGTTAATTACTCAATT
GCACAAACTAATTGTTCCAAGGAGGAATTTTCATTCTTAACTCCAGACTGCAAGTCCCTT
TCAAGTGGTGATACTGGTGAATGTACAGATAAAGCACATGTAGATGTCAAGCTAAGAATT
TCTTCCTTCTCGCAGAAATGTGACCTTTATCCAGTGAAGGATTTTGTACAACCACCCACC
AGGCTTTGTGCCGGCTGCCCCAAACCTATACCTGTTGACAGCCCAGACCTGGAGGAGCCT
CTGAGCCATTCCATCGCAAAGCTTAATGCAGAGCATGATGGAGCCTTCTATTTCAAGATT
GACACTGTGAAAAAAGCAACAGTACAGGTGGTAGCTGGATTGAAGTATTCTATTGTGTTC
ATAGCAAGGGAAACCACATGTTCTAAGGGAAGTAATGAAGAGCTGACCAAGAGTTGTGAG
ATCAATATACATGGTCAAATTCTACACTGTGATGCTAATGTCTATGTGGTGCCTTGGGAG
GAAAAAGTTTACCCTACTGTCAACTGTCAACCACTTGGACAGACCTCACTCATGAAAAGG
CCTCCGGGTTTTTCACCTTTCCGATCAGTTCAAGTGATGAAAACTGAAGGAAGCACAACT
GTAAGTCTACCCCACTCTGCCATGTCACCTGTACAAGATGAAGAGCGGGATTCAGGAAAA
GAACAAGGACCCACTCATGGGCATGGCTGGGACCATGGAAAGCAAATAAAATTACATGGC
CTTGGCCTTGGCCATAAACATAAGCATGACCAAGGTCATGGGCACCATGGAAGTCATGGT
CTTGGCCATGGACATCAAAAGCAACATGGTCTTGGCCATGGACATAAGCATGGTCATGGC
CACGGAAAACATAAAAACAAAGGAAAAAACAATGGAAAGCATTATGATTGGAGGACACCC
TATTTGGCAAGTTCTTATGAAGATAGCACTACATCCTCTGCACAGACGCAAGAGAAGACA
GAAGAGACAACACTCTCTTCCCTAGCCCAGCCAGGTGTAGCCATTACCTTTCCTGACTTT
CAGGACTCAGATCTCATTGCAACTGTGATGCCTAATACACTACCACCTCACACAGAGAGT
GATGATGACTGGATCCCTGACATCCAGACAGAGCCAAATAGCCTTGCATTTAAATTGATT
TCAGACTTTCCAGAAACAACCTCCCCCAAATGTCCTAGTCGCCCCTGGAAGCCAGTTAAT
GGAGTGAATCCAACTGTGGAAATGAAAGAGTCTCATGATTTTGATCTTGTTGATGCTCTT
CTTTAA
Protein Properties
Number of Residues 621
Molecular Weight 68890.0
Theoretical pI 6.61
Pfam Domain Function Not Available
Signals
  • 1-18
Transmembrane Regions Not Available
Protein Sequence
>Kininogen-1
MKLITILFLCSRLLPSLTQESSQEIDCNDQDVFKAVDAALTKYNSENKSGNQFVLYRITE
VARMDNPDTFYSLKYQIKEGDCPFQSNKTWQDCDYKDSAQAATGECTATVAKRGNMKFSV
AIQTCLITPAEGPVVTAQYECLGCVHPISTKSPDLEPVLRYAIQYFNNNTSHSHLFDLKE
VKRAQRQVVSGWNYEVNYSIAQTNCSKEEFSFLTPDCKSLSSGDTGECTDKAHVDVKLRI
SSFSQKCDLYPVKDFVQPPTRLCAGCPKPIPVDSPDLEEPLSHSIAKLNAEHDGAFYFKI
DTVKKATVQVVAGLKYSIVFIARETTCSKGSNEELTKSCEINIHGQILHCDANVYVVPWE
EKVYPTVNCQPLGQTSLMKRPPGFSPFRSVQVMKTEGSTTVSLPHSAMSPVQDEERDSGK
EQGPTHGHGWDHGKQIKLHGLGLGHKHKHDQGHGHHGSHGLGHGHQKQHGLGHGHKHGHG
HGKHKNKGKNNGKHYDWRTPYLASSYEDSTTSSAQTQEKTEETTLSSLAQPGVAITFPDF
QDSDLIATVMPNTLPPHTESDDDWIPDIQTEPNSLAFKLISDFPETTSPKCPSRPWKPVN
GVNPTVEMKESHDFDLVDALL
GenBank ID Protein CAA24735.1
UniProtKB/Swiss-Prot ID P01044
UniProtKB/Swiss-Prot Entry Name KNG1_BOVIN
PDB IDs Not Available
GenBank Gene ID V01491
GeneCard ID KNG1
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available