| Identification |
|---|
| BMDB Protein ID
| BMDBP00922 |
| Secondary Accession Numbers
| |
| Name
| Ornithine decarboxylase |
| Synonyms
|
Not Available
|
| Gene Name
| ODC1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. |
| Pathways
|
- Amine and polyamine biosynthesis
- Putrescine biosynthesis via L-ornithine pathway
- Putrescine from L-ornithine: step 1/1
|
| Reactions
|
| Ornithine → Putrescine + Carbon dioxide |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| Not Available |
| SNPs
| ODC1 |
| Gene Sequence
|
>1386 bp
ATGAACAGCTTTAGCAATGAAGAGTTTGACTGCCATTTCTTGGATGAAGGCTTTACTGCC
AAGGATATTCTGGACCAAAAAATTAATGAAGTTTCTTATTCTGATGATAAGGATGCCTTC
TATGTTGCGGACCTGGGAGACATTCTGAAGAAACATCTGAGATGGTTGAAAGCTCTTCCT
CGGGTCACCCCCTTTTATGCCGTCAAATGCAATGATAGCAGAACCATAGTGAAGACACTC
GCTGCCATTGGGACAGGATTTGACTGTGCCAGCAAGACTGAAATACAATTGGTGCAGAGT
CTCGGGGTGCCCCCAGAGAGGATTATCTATGCAAATCCATGTAAACAAGTGTCTCAGATT
AAGTATGCTGCCAATAACGGAGTCCAGATGATGACTTTTGATAGTGAAGTTGAGCTGATG
AAAGTTGCCAGGGCACATCCAAAGGCCAAGTTGGTTTTACGGATCGCCACTGATGATTCC
AAAGCAGTCTGTCGCCTCAGTGTCAAATTTGGTGCCACACTCAAAACCAGCAGGCTTCTT
TTGGAACGGGCGAAAGAGCTAGATATTGATGTCATTGGTGTCAGCTTCCACGTGGGAAGT
GGCTGTACTGATCCTGAGACCTTTGTGCAGGCCATCTCTGATGCCCGCTGTGTCTTTGAC
ATGGGCGCTGAGGTTGGTTTCAACATGTATCTGCTTGATATTGGTGGTGGCTTTCCTGGA
TCAGAGGATGTAAAGCTTAAATTTGAAGAGATCACCAGTGTAATCAACCCAGCACTGGAC
AAGTATTTTCCATCAGACTCTGGAGTGAGAATCATAGCTGAGCCAGGCAGATACTATGTT
GCATCAGCTTTCACGCTCGCAGTTAATATTATTGCCAAAAAACTTGTATTAAAGGAACAG
ACAGGCTCTGATGATGAAGAGGAGTCAACTGATCGGACATTTATGTATTATGTGAACGAT
GGAGTATATGGGTCATTCAACTGCATCCTTTATGATCACGCACACGTGAAGCCTCTTCTG
CAGAAGAGACCCAAACCAGATGAGAAGTATTATTCATCCAGCATCTGGGGACCGACCTGT
GACGGCCTGGACCGCATTGTTGAGCGCTGTAACCTGCCTGAGATGCATGTGGGTGATTGG
ATGCTCTTTGAGAACATGGGTGCTTACACTGTTGCTGCTGCTTCTACCTTCAATGGATTC
CAGAGACCCACCATCTACTATGTGATGTCAGGGCCAACGTGGCAACTGATGCAGCAGATC
CGGACCCAGGACTTCCCGCCTGGAGTGGAGGAGCCGGACGTCGGTCCCCTGCCCGTGTCC
TGTGCCTGGGAGAGCGGCATGAAGCGGCACTCGGCAGCCTGCGCTTCCACGCGTATTAAC
GTGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 461 |
| Molecular Weight
| 51346.0 |
| Theoretical pI
| 5.12 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Ornithine decarboxylase
MNSFSNEEFDCHFLDEGFTAKDILDQKINEVSYSDDKDAFYVADLGDILKKHLRWLKALP
RVTPFYAVKCNDSRTIVKTLAAIGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQI
KYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLKTSRLL
LERAKELDIDVIGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFNMYLLDIGGGFPG
SEDVKLKFEEITSVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKLVLKEQ
TGSDDEEESTDRTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTC
DGLDRIVERCNLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPTWQLMQQI
RTQDFPPGVEEPDVGPLPVSCAWESGMKRHSAACASTRINV
|
| External Links |
|---|
| GenBank ID Protein
| AAA92339.1 |
| UniProtKB/Swiss-Prot ID
| P27117 |
| UniProtKB/Swiss-Prot Entry Name
| DCOR_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| M92441 |
| GeneCard ID
| ODC1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
